DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7166 and Lrit1

DIOPT Version :9

Sequence 1:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_666357.2	Gene:	Lrit1 / 239037	MGIID:	2385320	Length:	624	Species:	Mus musculus

Alignment Length:	289	Identity:	66/289 - (22%)
Similarity:	103/289 - (35%)	Gaps:	72/289 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TAPKFLSRGHLYKVIVG---ETIELPCKVQNLGSFVLLWRKGSSVLTAGHLKITRDQRFKIVGDY 98
            |.| ||| ||..::|:|   ......|::.:|...:..|...:.:.....|:....:....|...
Mouse   183 TGP-FLS-GHHARLILGLQDNPWVCDCRLYDLVHLLDGWVSSNLIFIEARLRCASPRSLAGVAFS 245

  Fly    99 NLQINGVKTQDAGDYICQLGDQENRDQVHTVEILVPPTLRALPHNGQVTARKGSTVTLECKASGN 163
            .|::..          ||                 .|.||  |....:.:..||||.|.|.|:|.
Mouse   246 QLELRK----------CQ-----------------SPELR--PGVTSIISPLGSTVLLRCGATGI 281

  Fly   164 PVPTIFWFKKD--VFSGPTH---LSDSST---LILENVDRHHAGTYQCSADN--GVKDRVSMDIQ 218
            |.|.:.|.:.:  ..:|..|   .||.|:   |.|..|....:|.|.|.|.|  |..:.:   |.
Mouse   282 PGPEMSWRRANGRPLNGTVHQEVSSDGSSWTLLDLPVVSLFDSGDYICQAKNFLGASETL---IS 343

  Fly   219 LTILSPPEITVEKS-----WVHASEG-----YDVELVC--IVHGDVN------------SEMLWY 259
            |.:..|...|....     |....||     |:.:||.  :.|...:            .|.|..
Mouse   344 LIVTEPQTSTGYSGIPGVLWARTGEGAEAAAYNNKLVARHVPHMPEHVALATKPSMPSIKEELAL 408

  Fly   260 QNSFLLDATDRRSMYPRDDRYSLIIRNFQ 288
            || |.:|.....|..|.:.:.:.::|:.:
Mouse   409 QN-FQMDVPGEFSREPSEHQEAQMVRSLK 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	10/85 (12%)
		Ig	56..116	CDD:143165	6/59 (10%)
		IG_like	144..221	CDD:214653	27/86 (31%)
		IGc2	151..209	CDD:197706	24/67 (36%)
		IG_like	232..313	CDD:214653	16/81 (20%)
		Ig	242..311	CDD:143165	12/61 (20%)
Lrit1	NP_666357.2	LRRNT	23..61	CDD:214470
		LRR 1	60..81
		LRR_8	63..143	CDD:290566
		leucine-rich repeat	64..84	CDD:275378
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..129
		LRR_8	131..>176	CDD:290566
		LRR_4	131..172	CDD:289563
		LRR 4	132..153
		leucine-rich repeat	133..156	CDD:275378
		LRR 5	156..177
		leucine-rich repeat	157..180	CDD:275378
		leucine-rich repeat	181..205	CDD:275378	9/23 (39%)
		TPKR_C2	201..>241	CDD:301599	4/39 (10%)
		Ig	258..346	CDD:299845	29/92 (32%)
		IG_like	268..346	CDD:214653	27/80 (34%)
		FN3	432..502	CDD:214495	1/5 (20%)
		LRR 6	526..549
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900