DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7166 and wrk-1

DIOPT Version :9

Sequence 1:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001024651.1	Gene:	wrk-1 / 181093	WormBaseID:	WBGene00006942	Length:	452	Species:	Caenorhabditis elegans

Alignment Length:	468	Identity:	113/468 - (24%)
Similarity:	190/468 - (40%)	Gaps:	74/468 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TTAPKFLSRGHLYKVIVGETIELPCKVQNLGSFVLLWRKGSSVLTAGHLKITRDQRFKIVGDYNL 100
            :|:.:..::|.......||::.|.|:|:: .|..::|||.:.|:...      |:.....|.|.:
Worm    15 STSAQIRTKGGTLIAKEGESLTLRCEVED-PSVAIIWRKNTEVVAVD------DEILDTYGGYEI 72

  Fly   101 QING---------VKTQDAGDYICQLGDQE------NRDQV-HTVEILVPPTLRALPHNGQVTAR 149
            .:.|         |:..::.:|.|.|.:.|      .:.|| ...::.|.|.:...|..|...||
Worm    73 SMEGSTSVLTIKRVEPINSANYSCALAEPEVSVTFVIKVQVFKPTQVSVKPLVVISPDTGVYHAR 137

  Fly   150 KGS---TVTLECKASGNPVPTIFWFK------KDVFSGPTHLSDSSTLILENVDRHHAGTYQCSA 205
            .|.   .:|...| .|||.|.:.|.|      :|:    ......:.:::..|.:||||.|.|.|
Worm   138 VGEKNLVITCHVK-EGNPKPGVVWTKQAAKLPEDI----KREHGGARIVITEVKKHHAGKYNCLA 197

  Fly   206 DN-GVKDRVSMDIQLTILSP--------PEITVEKSWVHASEGYDVELVCIVHGDVNSEMLWYQN 261
            :| ...||.::||.  :..|        |.:..|.:::...:..:....|...|....::.|..|
Worm   198 ENIAGSDRATIDIH--VAEPLQGEREEKPWVKNEDTFIPVRKNQNASFWCTYDGTPVPQVEWLFN 260

  Fly   262 SFLLDATDRR-----SMYPRDDRYS---LIIRNFQPTDFGNYSCVADNALGRTKKYIEVSGRPGP 318
            .:.::..|.:     ....|.:.||   |.:.:.....||:|:|...|.||.....:.|||||||
Worm   261 GYKINFNDEKFKKTSETAQRLNGYSKSTLTVGDISEEAFGDYACRISNKLGSVTAVVHVSGRPGP 325

  Fly   319 ADFISPALSGFLDHYNLTWTIESIPPLDEIKLLYRRLLMNETYQHPGKWHEYHIKPTPIRTDGSH 383
                 |.||  .|...||||:.:...:.|.:|.:|  |.|..:..|...:...:|.:....|...
Worm   326 -----PQLS--FDESELTWTVRAFDKILEYQLCHR--LENADHFLPEDCNSVRVKKSDNNGDDKW 381

  Fly   384 FLMSYLVKNLEHNAVYEAIVQAKNKYGWNEISDIHQFYTRNHDLLLDIDMEYKMGISSNIRISPT 448
            .....|...|||...|...::|:|..||..::.     ...|..|..|:.|...|.|    |...
Worm   382 THTIDLSTFLEHGNKYHVQLKARNALGWGSMAK-----DALHVELQRIEKEEAKGAS----IISI 437

  Fly   449 VSGIILSAFILVL 461
            :|.|:::...:.|
Worm   438 ISSILVTLVTMYL 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	21/98 (21%)
		Ig	56..116	CDD:143165	14/68 (21%)
		IG_like	144..221	CDD:214653	26/86 (30%)
		IGc2	151..209	CDD:197706	19/67 (28%)
		IG_like	232..313	CDD:214653	16/88 (18%)
		Ig	242..311	CDD:143165	16/76 (21%)
wrk-1	NP_001024651.1	IG_like	25..113	CDD:214653	19/94 (20%)
		IGc2	31..96	CDD:197706	16/71 (23%)
		IG_like	132..212	CDD:214653	26/86 (30%)
		IGc2	142..202	CDD:197706	18/64 (28%)
		IG_like	235..320	CDD:214653	16/84 (19%)
		Ig	245..318	CDD:143165	16/72 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I8517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	118	1.000	Inparanoid score	I3357
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28857
OrthoDB	1	1.010	-	-		D332048at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14108
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.980