DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7166 and igcm-2

DIOPT Version :9

Sequence 1:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001362087.1	Gene:	igcm-2 / 180913	WormBaseID:	WBGene00020130	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	423	Identity:	113/423 - (26%)
Similarity:	166/423 - (39%)	Gaps:	89/423 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 APKFLSR----GHL--YKVIVGETIELPCKVQ--NLGSFVLLWRK-GSSVLTA-----GHLKITR 88
            |.||:.|    |.:  |....|..|.|||.:.  |..||.|.||| |..:|:|     ||:..|.
Worm     7 AAKFIRRQTDDGEMKAYWGKAGAPITLPCSISLFNEESFSLDWRKDGQLILSAFGQEQGHVTPTL 71

  Fly    89 DQRFKIVGDYNLQINGVKTQDAGDYIC---QLGDQENRDQ--------VHTVEILVPPTLRALPH 142
            ..|....|...:.|:.|...|||.|.|   :...|..|.:        |:...:::.|:..|:.|
Worm    72 QGRLARDGFLGITIHSVTDGDAGVYQCIVTKFSKQPTRPEKGLSAKLVVNVPPVIISPSKNAIIH 136

  Fly   143 NGQVTARKGSTVTLECKASGNPVPTIFWFKKDVFSGPTHLSDSSTLILENVDRHHAGTYQCSADN 207
            .     :.|:.:..||||.|.|.|.|.|.:.:..     :|.|..|.|.|::....|.|.|.|.|
Worm   137 K-----KVGADLIFECKAEGAPSPEITWSRNEQI-----ISTSPVLTLSNLEEGDKGLYTCLAVN 191

  Fly   208 --GVKDRVSMDIQL---TILSPPEITVEKSWVHASEGYDVELVCIVHGDVNSEMLWYQNSFLLDA 267
              | ....|:|::.   |||.  .|.:.|:.:   ||.:|...|  |.:..:..:.|...|....
Worm   192 IEG-NSTSSIDVRFTKATILD--LIPLNKTVI---EGSNVFWHC--HANAQATAISYSWLFEKKP 248

  Fly   268 TDRRSMYPRDDRYS--LIIRNFQPTDFGNYSCVADNALGRTKK---YIEVSGRPGPADFISP--- 324
            ....|:..|.:..|  |.:::.:.:|.|.|:|.|.|:.|.|..   |:.|...|.|.....|
Worm   249 IKTTSLGLRSNIRSGDLSLQDVRKSDSGWYTCEAKNSAGETTSSTAYLHVFYPPEPLSSHQPVQT 313

  Fly   325 ALSGFLDHYNLTWTIESIPPLDEIKLLYRRLLMNET---YQHPGKWHEY-HIKPTPIRTDGSHFL 385
            ..||    .|.|.:.:              ::.|.|   |    .|.:. |..||..   .||.:
Worm   314 VASG----RNTTVSCD--------------VIANPTPTSY----TWSKNGHYLPTQA---SSHII 353

  Fly   386 MSYLVKNLEHNAVYEAIVQAKNKYGWNEISDIH 418
            :||....  ...:|..  ||.|..|...|.:.|
Worm   354 ISYAKPG--DGGIYGC--QADNIAGKGSIVETH 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	30/101 (30%)
		Ig	56..116	CDD:143165	26/70 (37%)
		IG_like	144..221	CDD:214653	23/81 (28%)
		IGc2	151..209	CDD:197706	20/59 (34%)
		IG_like	232..313	CDD:214653	20/85 (24%)
		Ig	242..311	CDD:143165	18/73 (25%)
igcm-2	NP_001362087.1	IG_like	23..101	CDD:214653	28/77 (36%)
		Ig	124..200	CDD:386229	24/86 (28%)
		IG_like	214..298	CDD:214653	21/88 (24%)
		Ig_3	309..371	CDD:372822	19/90 (21%)
		Ig	389..467	CDD:386229
		FN3	476..548	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810