DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7166 and Mag

DIOPT Version :9

Sequence 1:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001333013.1	Gene:	Mag / 17136	MGIID:	96912	Length:	627	Species:	Mus musculus

Alignment Length:	410	Identity:	90/410 - (21%)
Similarity:	152/410 - (37%)	Gaps:	84/410 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 NDPPTTAPKFLSRGHLYKVIVGETIELPCKV----------------QNLGSFVLLWR----KGS 76
            |.|....|.        :|:.|..:|:.|.|                :.||...:|.|    :|:
Mouse   139 NTPNIVVPP--------EVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPTVLGRLREDEGT 195

  Fly    77 SV-LTAGHLKITRDQRFKIVG------DYNLQINGVKTQDAGDYICQLGDQENRDQVHTVEILVP 134
            .| ::..|...||:.....:|      :..||..|..:.|                     :..|
Mouse   196 WVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLD---------------------VKYP 239

  Fly   135 PTLRALPHNGQVTARKGSTVTLECKASGNPVPTIFWFKKDVFSGPTHLSDSSTLILENVDRHHAG 199
            |.:  :..|..|.|.:||.|:|.|.|..||.|.:.|.:..:..... ::.|..|.||.|.....|
Mouse   240 PVI--VEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGMVLREA-VAKSLYLDLEEVTPGEDG 301

  Fly   200 TYQCSADN--GVKDRVSMDIQLTILSPPEITVEKSWVHASEGYDVELVCIVHGDVNSEMLWYQNS 262
            .|.|.|:|  |..:|.   ::|:::..|........|.|.||..|.::|....:.:..:..::..
Mouse   302 VYACLAENAYGQDNRT---VELSVMYAPWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEK 363

  Fly   263 FLLDATDRRSMYPRDDRYSLIIRNFQPTDFGNYSCVADNALGRTKKYIEVSGRPGPADFISPALS 327
            .:|...    :|  :.:..|.:....|.|.|.|.|||:|..|:......:|....|...:....:
Mouse   364 QILATV----IY--ESQLQLELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESHCA 422

  Fly   328 GFLDHYNLTWTIESIP-PLDEIKLLYRRLLMNETYQHPGKWHEYHIKPTPIRTDGSHFLM-SYLV 390
            ...|.......::|.| |....:|..|.:.:|||.:      |:      :.::.|..|: |.|.
Mouse   423 AARDTVQCLCVVKSNPEPSVAFELPSRNVTVNETER------EF------VYSERSGLLLTSILT 475

  Fly   391 KNLEHNAVYEAIVQAKNKYG 410
            ...:..|....|..::|.||
Mouse   476 IRGQAQAPPRVICTSRNLYG 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	19/109 (17%)
		Ig	56..116	CDD:143165	17/86 (20%)
		IG_like	144..221	CDD:214653	25/78 (32%)
		IGc2	151..209	CDD:197706	20/59 (34%)
		IG_like	232..313	CDD:214653	18/80 (23%)
		Ig	242..311	CDD:143165	14/68 (21%)
Mag	NP_001333013.1	Interaction with RTN4R and RTN4RL2. /evidence=ECO:0000250\|UniProtKB:P07722	20..325		50/220 (23%)
		IgV_CD33	22..137	CDD:409377
		Ig strand B	38..42	CDD:409377
		Ig strand C	56..60	CDD:409377
		Ganglioside GT1b binding. /evidence=ECO:0000269\|PubMed:27922006	65..67
		Ig strand E	100..104	CDD:409377
		Ig strand F	114..119	CDD:409377
		Ganglioside GT1b binding. /evidence=ECO:0000269\|PubMed:27922006	124..128
		Ig strand G	128..133	CDD:409377
		IgC2_CD33_d2_like	141..235	CDD:409579	20/101 (20%)
		Ig strand B	155..159	CDD:409579	1/3 (33%)
		Ig strand C	171..175	CDD:409579	0/3 (0%)
		Ig strand E	200..204	CDD:409579	0/3 (0%)
		Ig strand F	214..219	CDD:409579	1/4 (25%)
		Ig strand G	229..232	CDD:409579	1/2 (50%)
		Ig_3	239..309	CDD:404760	24/72 (33%)
		Ig strand A	239..242	CDD:409353	2/2 (100%)
		Ig strand A'	248..251	CDD:409353	1/2 (50%)
		Ig strand B	256..264	CDD:409353	3/7 (43%)
		Ig strand C	270..274	CDD:409353	0/3 (0%)
		Ig strand C'	277..280	CDD:409353	0/2 (0%)
		Ig strand E	289..293	CDD:409353	1/3 (33%)
		Ig strand F	301..309	CDD:409353	4/7 (57%)
		Ig strand G	312..322	CDD:409353	3/12 (25%)
		IG	333..409	CDD:214652	18/81 (22%)
		Required for normal axon myelination in the central nervous system. /evidence=ECO:0000269\|PubMed:9482783	578..627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000