DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7166 and Dscam

DIOPT Version :9

Sequence 1:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_038943864.1	Gene:	Dscam / 171119	RGDID:	619992	Length:	2034	Species:	Rattus norvegicus

Alignment Length:	455	Identity:	103/455 - (22%)
Similarity:	173/455 - (38%)	Gaps:	95/455 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PKFLSRGHLYKVIVGETIELPCKVQNLGS--FVLLWRKGSSVLTAGHLKITRDQRFKIVGDYNLQ 101
            |.|:......:..:|:.:.:||.|.: |.  ..:.|:|....:.|. |.:|.|   .|....:|:
  Rat   596 PPFIQPFEFPRFSIGQRVFIPCVVVS-GDLPITITWQKDGRPIPAS-LGVTID---NIDFTSSLR 655

  Fly   102 INGVKTQDAGDYICQLGDQENRDQVHTVE------ILVPPTLRALPHNGQVTARKGSTVTLECKA 160
            |:.:.....|:|.|..     |::...||      :.|||.....|.:..  ...|..|.|.|.|
  Rat   656 ISNLSLMHNGNYTCIA-----RNEAAAVEHQSQLIVRVPPKFVVQPRDQD--GIYGKAVILNCSA 713

  Fly   161 SGNPVPTIFW----------FKKDVFSGPTHLSDSSTLILENVDRHHAGTYQCSADNGVKDRVSM 215
            .|.|||||.|          |:....:|...:..:.:|::::|....:|.|.|...|.|...||.
  Rat   714 EGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSK 778

  Fly   216 DIQLTILSPPEITVEKSWVHASEGYDVELVCIVHGDVNSEMLWYQNSFLLDATDRRSMYPRDDRY 280
            .:.||:..|..||...:...|::|...|:.|..||:....:.|.:...:::....|.:....:..
  Rat   779 SMYLTVKIPAMITSYPNTTLATQGQRKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVG 843

  Fly   281 SLIIRNFQ--PT---DFGNYSCVADNALGRTKKYIEVSGRPGPADFISPALSGFLDHYNLTWTIE 340
            ..:|...|  ||   |.|.:||.|.|:.|..:..|:::.:..|.
  Rat   844 EEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPD--------------------- 887

  Fly   341 SIPPLDEIK-LLYRRLLMNETYQHPGKWHEYHIKPTPI------------------RT-DGSHFL 385
              ||..||| :..|.:.:..|....|.        :||                  || |.|..|
  Rat   888 --PPEIEIKDVKARTITLRWTMGFDGN--------SPITGYDIECKNKSDSWDSAQRTKDVSPQL 942

  Fly   386 MSYLVKNLEHNAVYEAIVQAKNKYGWNEISDIHQFYTRNHDLLLDIDMEYKMGISSNIRISPTVS 450
            .|..:.::..::.|...:.|||:.|.:|.|         :::.:..|.....|....:.:.||.|
  Rat   943 NSATIIDIHPSSTYSIRMYAKNRIGKSEPS---------NEITITADEAAPDGPPQEVHLEPTSS 998

Fly 451 450
Rat 999 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	20/90 (22%)
		Ig	56..116	CDD:143165	15/61 (25%)
		IG_like	144..221	CDD:214653	24/86 (28%)
		IGc2	151..209	CDD:197706	20/67 (30%)
		IG_like	232..313	CDD:214653	20/85 (24%)
		Ig	242..311	CDD:143165	17/73 (23%)
Dscam	XP_038943864.1	Ig	26..121	CDD:416386
		Ig strand A'	33..37	CDD:409353
		Ig strand B	40..49	CDD:409353
		Ig strand C	55..61	CDD:409353
		Ig strand C'	63..66	CDD:409353
		Ig strand D	72..75	CDD:409353
		Ig strand E	80..85	CDD:409353
		Ig strand F	98..106	CDD:409353
		Ig strand G	109..121	CDD:409353
		Ig	125..210	CDD:416386
		Ig strand A	126..130	CDD:409353
		Ig strand A'	132..136	CDD:409353
		Ig strand B	139..149	CDD:409353
		Ig strand C	157..163	CDD:409353
		Ig strand C'	164..167	CDD:409353
		Ig strand E	179..185	CDD:409353
		Ig strand F	191..201	CDD:409353
		IGc2	239..300	CDD:197706
		Ig strand B	242..246	CDD:409353
		Ig strand C	255..259	CDD:409353
		Ig strand F	290..295	CDD:409353
		Ig	313..395	CDD:416386
		Ig strand A	314..319	CDD:409353
		Ig strand A'	322..326	CDD:409353
		Ig strand B	329..339	CDD:409353
		Ig strand C	344..350	CDD:409353
		Ig strand C'	351..354	CDD:409353
		Ig strand E	368..374	CDD:409353
		Ig strand F	381..389	CDD:409353
		Ig	406..501	CDD:416386
		Ig strand A	406..409	CDD:409353
		Ig strand A'	415..419	CDD:409353
		Ig strand B	422..431	CDD:409353
		Ig strand C	436..442	CDD:409353
		Ig strand C'	444..447	CDD:409353
		Ig strand D	452..460	CDD:409353
		Ig strand E	464..473	CDD:409353
		Ig strand F	480..488	CDD:409353
		Ig strand G	491..501	CDD:409353
		Ig	504..593	CDD:416386
		Ig strand A	505..507	CDD:409353
		Ig strand A'	512..516	CDD:409353
		Ig strand B	519..526	CDD:409353
		Ig strand C	533..539	CDD:409353
		Ig strand C'	540..542	CDD:409353
		Ig strand D	549..553	CDD:409353
		Ig strand E	557..563	CDD:409353
		Ig strand F	571..579	CDD:409353
		Ig strand G	583..593	CDD:409353
		Ig	596..686	CDD:416386	22/99 (22%)
		Ig strand A	597..599	CDD:409353	0/1 (0%)
		Ig strand B	611..620	CDD:409353	2/8 (25%)
		Ig strand C	625..632	CDD:409353	1/6 (17%)
		Ig strand C'	634..636	CDD:409353	0/1 (0%)
		Ig strand D	643..648	CDD:409353	2/7 (29%)
		Ig strand E	651..658	CDD:409353	2/6 (33%)
		Ig strand F	665..673	CDD:409353	3/12 (25%)
		Ig strand G	676..685	CDD:409353	2/8 (25%)
		Ig_DSCAM	689..784	CDD:409397	27/96 (28%)
		Ig strand B	707..711	CDD:409397	2/3 (67%)
		Ig strand C	720..724	CDD:409397	2/3 (67%)
		Ig strand E	749..753	CDD:409397	1/3 (33%)
		Ig strand F	763..768	CDD:409397	2/4 (50%)
		Ig strand G	777..780	CDD:409397	1/2 (50%)
Ig_DSCAM	785..884	CDD:409398	23/98 (23%)
Ig strand B	805..809	CDD:409398	1/3 (33%)
Ig strand C	818..822	CDD:409398	0/3 (0%)
Ig strand E	848..852	CDD:409398	0/3 (0%)
Ig strand F	862..867	CDD:409398	2/4 (50%)
Ig strand G	875..878	CDD:409398	0/2 (0%)
FN3	885..978	CDD:238020	24/132 (18%)
FN3	986..1083	CDD:238020	4/13 (31%)
FN3	1091..1184	CDD:238020
FN3	1189..1278	CDD:238020
Ig_3	1287..1363	CDD:404760
Ig strand B	1303..1307	CDD:409353
Ig strand C	1316..1320	CDD:409353
Ig strand E	1342..1346	CDD:409353
Ig strand F	1356..1361	CDD:409353
FN3	1380..1470	CDD:238020
FN3	1486..1555	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810