DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7166 and SIGLEC14

DIOPT Version :9

Sequence 1:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001092082.1	Gene:	SIGLEC14 / 100049587	HGNCID:	32926	Length:	396	Species:	Homo sapiens

Alignment Length:	366	Identity:	70/366 - (19%)
Similarity:	112/366 - (30%)	Gaps:	102/366 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 GETIELPCKVQNLGSFVLLWRKGSS--------------------VLTAG---HLKITRDQRFKI 94
            |..:.:||      ||...||...|                    |.|..   .:|.....||::
Human    34 GLCVLVPC------SFSYPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRL 92

  Fly    95 VGDY-----NLQINGVKTQDAGDYICQL--------GDQENRDQVHTVEILVPPTLRALPHNGQV 146
            :||.     :|.|...:.:|.|.|..::        ..|:|:..:....::..|.:..|.
Human    93 LGDVQKKNCSLSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLE----- 152

  Fly   147 TARKGSTVTLECKASGN----PVPTIFWFKKDVFSGPTHLSDSSTLILENVDRHHAGTYQCSAD- 206
            ....|....|.|...|:    |..|..|....:.......:.||.|.|......|.....|...
Human   153 PLESGRPTRLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKR 217

  Fly   207 NGVKDRVSMDIQLTILSPPE-----------------ITVEKSWVHASEGYDVELVCIVHGDVNS 254
            .|.:......:||.:...|:                 |......|...||..:.|.|.|..:..:
Human   218 QGAQVTTERTVQLNVSYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQSLFLACTVDSNPPA 282

  Fly   255 EMLWYQNSFLLDATDRRSMYPRDDRYS--LIIRNFQPTDFGNYSCVADNALGR------------ 305
            .:.|::        :.:::.|.....|  |.:.|....:.|.::|...:.||.
Human   283 SLSWFR--------EGKALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLGSQHLSFILSVQRS 339

  Fly   306 -------TKKYIEVSGRPGPADFISPAL--SGFLDHYNLTW 337
                   |:|  :....|.....|..||  :|||..|.|||
Human   340 SSSCICVTEK--QQGSWPLVLTLIRGALMGAGFLLTYGLTW 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	22/115 (19%)
		Ig	56..116	CDD:143165	19/87 (22%)
		IG_like	144..221	CDD:214653	16/81 (20%)
		IGc2	151..209	CDD:197706	13/62 (21%)
		IG_like	232..313	CDD:214653	17/101 (17%)
		Ig	242..311	CDD:143165	14/89 (16%)
SIGLEC14	NP_001092082.1	Ig_Siglec_N	21..140	CDD:143189	22/111 (20%)
		IG_like	26..139	CDD:214653	22/110 (20%)
		Ig	150..216	CDD:299845	14/70 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..209		5/18 (28%)
		Ig	252..335	CDD:299845	16/90 (18%)
		IG_like	261..336	CDD:214653	15/82 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910