DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRP6 and CG32432

DIOPT Version :9

Sequence 1:	NP_002327.2	Gene:	LRP6 / 4040	HGNCID:	6698	Length:	1613	Species:	Homo sapiens
Sequence 2:	NP_649266.1	Gene:	CG32432 / 40310	FlyBaseID:	FBgn0052432	Length:	1307	Species:	Drosophila melanogaster

Alignment Length:	316	Identity:	63/316 - (19%)
Similarity:	93/316 - (29%)	Gaps:	122/316 - (38%)

- Green bases have known domain annotations that are detailed below.

Human  1326 CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE--------------------LDCY-PTEEPAP- 1368
            |.:.:|.|:||:|:...|.|::..||.|.|||                    |:.: |.::..|
  Fly   214 CSLAEFSCSNGRCVPLSKYCNNLNDCGDGSDEPRFCTRCNRTYYGDIGQTYALELHRPKQDRVPF 278

Human  1369 -------QATNTVGSVIGVIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYV 1426
                   .|....|.|:.|.:..|..|..                    ..||..|   .|.||:
  Fly   279 VCVLTFTAAGGQHGDVVQVTLDSFTIGRF--------------------TSYVHEG---CPDGYM 320

Human  1427 PHPSSLSGSLPGM------------SRGKSMISSL---SIMGGSSGPPYD---RAHVTGASSS-- 1471
            ....|....:.||            |..:|:|.::   .:....||..:|   |..|....||
  Fly   321 QIAESARTPIGGMWCGSSWGPVLFYSETRSLIFTIRLNRLARDQSGYNFDFRIRYKVLSRDSSVT 385

Human  1472 --------------------------------SSSSTKGTYFPAILNPPPSPATERS-HYTMEF- 1502
                                            .....:|.  |.||....:.:..|| .|..:|
  Fly   386 RYGGIKLAELAQWHNRSSFLNQQQQQQQQQQQQQQQQQGA--PGILEDFTNSSVARSDRYGQDFS 448

Human  1503 ---GYSSNS----------PSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSR 1545
               .|::|.          ....::|: .|..|.....|.|.||....|.|..|.|
  Fly   449 LFSAYANNKTFMASLEKSLAKDEQNYT-EPKYYLGDLIPGTYCSRIFSDCDKKPCR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP6	NP_002327.2	Beta-propeller 1	20..275
		NHL	55..272	CDD:302697
		NHL repeat	55..93	CDD:271320
		LY	89..127	CDD:214531
		NHL repeat	97..132	CDD:271320
		NHL repeat	140..176	CDD:271320
		Ldl_recept_b	150..190	CDD:278487
		LY	175..216	CDD:214531
		NHL repeat	181..217	CDD:271320
		NHL repeat	226..253	CDD:271320
		LDL-receptor class B 5	237..276
		FXa_inhibition	286..323	CDD:291342
		Beta-propeller 2	328..589
		LY	353..393	CDD:214531
		LY	397..437	CDD:214531
		LY	438..481	CDD:214531
		LY	483..524	CDD:214531
		LY	525..558	CDD:214531
		FXa_inhibition	592..627	CDD:291342
		Beta-propeller 3	631..890
		LY	656..694	CDD:214531
		LY	697..739	CDD:214531
		LY	740..783	CDD:214531
		LY	783..825	CDD:214531
		LY	827..866	CDD:214531
		FXa_inhibition	893..929	CDD:291342
		Beta-propeller 4	933..1202
		LY	958..998	CDD:214531
		Ldl_recept_b	1069..1110	CDD:278487
		LY	1094..1136	CDD:214531
		FXa_inhibition	1207..1243	CDD:291342
		LDLa	1249..1285	CDD:238060
		LDLa	1288..1322	CDD:238060
		LDLa	1326..1360	CDD:238060	15/53 (28%)
		PPPSP motif A	1487..1493		0/5 (0%)
		PPPSP motif B	1527..1534		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1556..1613
		PPPSP motif C	1568..1575
		PPPSP motif D	1588..1593
		PPPSP motif E	1603..1610
CG32432	NP_649266.1	LDLa	214..245	CDD:197566	12/30 (40%)
		CUB	503..646	CDD:238001	1/1 (100%)
		LDLa	1203..1231	CDD:197566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900