| Sequence 1: | NP_002327.2 | Gene: | LRP6 / 4040 | HGNCID: | 6698 | Length: | 1613 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_729364.1 | Gene: | Culd / 38946 | FlyBaseID: | FBgn0035880 | Length: | 965 | Species: | Drosophila melanogaster |
| Alignment Length: | 938 | Identity: | 191/938 - (20%) |
|---|---|---|---|
| Similarity: | 270/938 - (28%) | Gaps: | 378/938 - (40%) |
- Green bases have known domain annotations that are detailed below.
|
Human 839 TQYQDYIYWTDW-SRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSG--WNECASSNGHC 900
Human 901 SHLCLAVP------------VGG--FVCGC-------PAHYSLNADNRTCSAPTTF--------L 936
Human 937 LFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFT 1001
Human 1002 VVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGR--------------SVGVVL 1052
Human 1053 ---KGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLG 1114
Human 1115 KLFWADSDLRRIESSDLSGANRIVLEDSNILQPVG----LTVFEN----------WL------YW 1159
Human 1160 IDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGC---SHIC--- 1218
Human 1219 ---LVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHS 1280
Human 1281 DELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDE-KNCE-------------------VL 1325
Human 1326 CLIDQF---RCANGQCI-----------------------GKHKK--CDHNVDCS---DKSDELD 1359
Human 1360 CYPTEEP-------------------------------AP--------QATN-TVGSVI------ 1378
Human 1379 ------------GVIVTIFVSGT--------VYFICQRML-----C-------PRMKGDGETMTN 1411
Human 1412 DYVVHGPASVPLGYVPHPSSLS--GSLPGMSRGKSMISSLSIMGGSSGPPYDRAH--VTGASSSS 1472
Human 1473 SSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPS------THRSYSYRPYSYRHFAPPTTP 1531
Human 1532 CSTDVCDSDYAPSRRMTSVATAKGYTSD 1559 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LRP6 | NP_002327.2 | Beta-propeller 1 | 20..275 | ||
| NHL | 55..272 | CDD:302697 | |||
| NHL repeat | 55..93 | CDD:271320 | |||
| LY | 89..127 | CDD:214531 | |||
| NHL repeat | 97..132 | CDD:271320 | |||
| NHL repeat | 140..176 | CDD:271320 | |||
| Ldl_recept_b | 150..190 | CDD:278487 | |||
| LY | 175..216 | CDD:214531 | |||
| NHL repeat | 181..217 | CDD:271320 | |||
| NHL repeat | 226..253 | CDD:271320 | |||
| LDL-receptor class B 5 | 237..276 | ||||
| FXa_inhibition | 286..323 | CDD:291342 | |||
| Beta-propeller 2 | 328..589 | ||||
| LY | 353..393 | CDD:214531 | |||
| LY | 397..437 | CDD:214531 | |||
| LY | 438..481 | CDD:214531 | |||
| LY | 483..524 | CDD:214531 | |||
| LY | 525..558 | CDD:214531 | |||
| FXa_inhibition | 592..627 | CDD:291342 | |||
| Beta-propeller 3 | 631..890 | 11/53 (21%) | |||
| LY | 656..694 | CDD:214531 | |||
| LY | 697..739 | CDD:214531 | |||
| LY | 740..783 | CDD:214531 | |||
| LY | 783..825 | CDD:214531 | |||
| LY | 827..866 | CDD:214531 | 6/27 (22%) | ||
| FXa_inhibition | 893..929 | CDD:291342 | 9/56 (16%) | ||
| Beta-propeller 4 | 933..1202 | 71/313 (23%) | |||
| LY | 958..998 | CDD:214531 | 9/39 (23%) | ||
| Ldl_recept_b | 1069..1110 | CDD:278487 | 11/40 (28%) | ||
| LY | 1094..1136 | CDD:214531 | 10/41 (24%) | ||
| FXa_inhibition | 1207..1243 | CDD:291342 | 7/44 (16%) | ||
| LDLa | 1249..1285 | CDD:238060 | 2/35 (6%) | ||
| LDLa | 1288..1322 | CDD:238060 | 14/34 (41%) | ||
| LDLa | 1326..1360 | CDD:238060 | 12/64 (19%) | ||
| PPPSP motif A | 1487..1493 | 2/5 (40%) | |||
| PPPSP motif B | 1527..1534 | 2/6 (33%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1556..1613 | 3/4 (75%) | |||
| PPPSP motif C | 1568..1575 | ||||
| PPPSP motif D | 1588..1593 | ||||
| PPPSP motif E | 1603..1610 | ||||
| Culd | NP_729364.1 | CUB | 200..298 | CDD:238001 | 31/113 (27%) |
| LDLa | 442..472 | CDD:238060 | 14/31 (45%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG1215 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 1 | 1.100 | - | - | O | PTHR24270 |
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 2.000 | |||||