| Sequence 1: | NP_002327.2 | Gene: | LRP6 / 4040 | HGNCID: | 6698 | Length: | 1613 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_610911.1 | Gene: | CG6553 / 36537 | FlyBaseID: | FBgn0033880 | Length: | 319 | Species: | Drosophila melanogaster |
| Alignment Length: | 249 | Identity: | 66/249 - (26%) |
|---|---|---|---|
| Similarity: | 87/249 - (34%) | Gaps: | 101/249 - (40%) |
- Green bases have known domain annotations that are detailed below.
|
Human 1238 QDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE--LNCPV--CSESQFQCASG 1298
Human 1299 QCIDGALRCNGDANCQDKSDEK-----------NCEVLCLIDQFRCANGQCIGKHKKCDHNVDCS 1352
Human 1353 DKSDELD--C----YPT--------------------------------------EEPAPQATN- 1372
Human 1373 ----------TVGSVIGVIVTIFVSGT-VYFICQRMLCP---RMKGDGETMTND 1412 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LRP6 | NP_002327.2 | Beta-propeller 1 | 20..275 | ||
| NHL | 55..272 | CDD:302697 | |||
| NHL repeat | 55..93 | CDD:271320 | |||
| LY | 89..127 | CDD:214531 | |||
| NHL repeat | 97..132 | CDD:271320 | |||
| NHL repeat | 140..176 | CDD:271320 | |||
| Ldl_recept_b | 150..190 | CDD:278487 | |||
| LY | 175..216 | CDD:214531 | |||
| NHL repeat | 181..217 | CDD:271320 | |||
| NHL repeat | 226..253 | CDD:271320 | |||
| LDL-receptor class B 5 | 237..276 | ||||
| FXa_inhibition | 286..323 | CDD:291342 | |||
| Beta-propeller 2 | 328..589 | ||||
| LY | 353..393 | CDD:214531 | |||
| LY | 397..437 | CDD:214531 | |||
| LY | 438..481 | CDD:214531 | |||
| LY | 483..524 | CDD:214531 | |||
| LY | 525..558 | CDD:214531 | |||
| FXa_inhibition | 592..627 | CDD:291342 | |||
| Beta-propeller 3 | 631..890 | ||||
| LY | 656..694 | CDD:214531 | |||
| LY | 697..739 | CDD:214531 | |||
| LY | 740..783 | CDD:214531 | |||
| LY | 783..825 | CDD:214531 | |||
| LY | 827..866 | CDD:214531 | |||
| FXa_inhibition | 893..929 | CDD:291342 | |||
| Beta-propeller 4 | 933..1202 | ||||
| LY | 958..998 | CDD:214531 | |||
| Ldl_recept_b | 1069..1110 | CDD:278487 | |||
| LY | 1094..1136 | CDD:214531 | |||
| FXa_inhibition | 1207..1243 | CDD:291342 | 1/4 (25%) | ||
| LDLa | 1249..1285 | CDD:238060 | 13/37 (35%) | ||
| LDLa | 1288..1322 | CDD:238060 | 13/44 (30%) | ||
| LDLa | 1326..1360 | CDD:238060 | 13/35 (37%) | ||
| PPPSP motif A | 1487..1493 | ||||
| PPPSP motif B | 1527..1534 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1556..1613 | ||||
| PPPSP motif C | 1568..1575 | ||||
| PPPSP motif D | 1588..1593 | ||||
| PPPSP motif E | 1603..1610 | ||||
| CG6553 | NP_610911.1 | LDLa | 34..60 | CDD:197566 | 11/36 (31%) |
| LDLa | 70..101 | CDD:197566 | 11/30 (37%) | ||
| LDLa | 115..146 | CDD:197566 | 11/34 (32%) | ||
| Frag1 | <260..>303 | CDD:287278 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG1215 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.900 | |||||