DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRP6 and CG6739

DIOPT Version :9

Sequence 1:	NP_002327.2	Gene:	LRP6 / 4040	HGNCID:	6698	Length:	1613	Species:	Homo sapiens
Sequence 2:	NP_609130.1	Gene:	CG6739 / 34037	FlyBaseID:	FBgn0031926	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	866	Identity:	172/866 - (19%)
Similarity:	274/866 - (31%)	Gaps:	271/866 - (31%)

- Green bases have known domain annotations that are detailed below.

Human   816 ESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDIL 880
            |:|::.||.|:  ....||...:|.            ::|:..|:.|.::      |.||.
  Fly    13 ETSSVTGLRRQ--PTKYPHGLNITV------------QTIDDDNEGSPKD------HSDYT---- 53

Human   881 VFHSSRQSGWNECASSNGHCSHL----CLA-VPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQ 940
              .:|..|.|::  :...|...|    .|| :.|..:.....|:|.||:.......||.::|...
  Fly    54 --RASGDSCWSK--TQKYHIGMLGSPETLAELQVRRYKYPLTANYYLNSKLERPEKPTPWMLLGY 114

Human   941 KSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWID----SRQNMIRKAQEDGSQGFT 1001
            ..::.|...       :..||..:.:|  :.:..|.....|:.    :|...:::..|
  Fly   115 ARSVCRWKY-------LRWPIIFVASV--LLFFGLITYCLWLHDVSVARAKFLQRRYE------- 163

Human  1002 VVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVI-----NVTRL-------DGRSVGVVLKG 1054
            ..::|..|.:.|:               |..|.|:..     ..|||       :...:..:..|
  Fly   164 ATLTSTSSSSNEV---------------WDEETTSSTERSPQETTRLEDMDDSDESTELPEIAFG 213

Human  1055 EQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVL-------FFSGLSKPIALAL--D 1110
            :...|.|   ..|.|                   ||...:.|       |.||......:.:  |
  Fly   214 DDGDPEA---GGEDG-------------------DGDYDDTLLPADSIRFTSGHQNSFGVPIEQD 256

Human  1111 SRLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGR 1175
            .|:.:|.   .:|.....:..:|....:...|..|.|.           :....:..|.:.:| .
  Fly   257 KRMLQLL---KELLHKPQATPAGNEPTLTRVSPTLPPP-----------LSASGRPTEAMALT-T 306

Human  1176 EGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDE 1240
            ...|....:...|.....|.:.:|...|:....:|     .:.:...|...|.:|.:...    |
  Fly   307 PSTTNSGCQSTMLPMCQGVLDYDLTFNREGAAPRD-----AVSMAAYDSLIRANCSVRAA----E 362

Human  1241 LSCGE-PPTCSPQQF---------------TC--------FTGEI-DC--IPVA---WRCDGFTE 1275
            ..||. .|.|.|...               .|        ..||: ||  .|.|   .:|:..|.
  Fly   363 FICGALEPECRPLHIGQLPPCRRICKAILEACSIPIYNSDVLGELFDCNLYPDAHESHKCEDPTR 427

Human  1276 CEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRC-ANGQCI 1339
            ..|:        |..::|||..|.||....:|:...:||...||....::|..|:||| :|.:|:
  Fly   428 RRDY--------CYGNEFQCHDGSCIPQNWQCDKIKDCQGGEDEDEQCLVCEPDEFRCRSNEKCL 484

Human  1340 GKHKKCDHNVDCSDKSDELDC--YPTEEPAPQATNTVGSVIGVIVTIFVSGTVYFICQRMLCPRM 1402
            .:..:||.|:||.|.|||.||  |.:.:.||...:.:.:...|           |.....|.|..
  Fly   485 VEKYRCDQNIDCMDGSDEQDCDEYGSGDLAPFDESELNAFPRV-----------FTYASFLSPNE 538

Human  1403 KGDGE----TMTND--------YVVHGPASVPLGYVPHPSSLSGSLPGMSRGKSMIS---SLSIM 1452
            ..|..    |.|.|        :.:|..|:      |.|...|.:..|....|..::   |..||
  Fly   539 TNDKVYTYITATTDEDAGTETKFQIHQVAA------PAPPVNSSAEEGAGGPKGFVNFRDSKEIM 597

Human  1453 GGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSY 1517
                             .:|.|.||                        |.||..:..|...:|
  Fly   598 -----------------MTSDSETK------------------------FKYSQRANRTSVKFS- 620

Human  1518 RPYSYRHFAPPTTPC---STDVCDSDYAPSRRMTSVATAKGYTSDLNYDSEPVPPPPT-----PR 1574
                   .:.||||.   |:.:..|.....|..|:..|....|:.....|....|..|     |.
  Fly   621 -------VSAPTTPAARTSSAIPSSALVQQRERTTSTTTTSTTTSTTTSSITSTPSITSTTLIPI 678

Human  1575 SQYLSAEENYE------SCPP 1589
            :...|....||      .|||
  Fly   679 NAATSEPNPYEVVTSLGGCPP 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRP6	NP_002327.2	Beta-propeller 1	20..275
		NHL	55..272	CDD:302697
		NHL repeat	55..93	CDD:271320
		LY	89..127	CDD:214531
		NHL repeat	97..132	CDD:271320
		NHL repeat	140..176	CDD:271320
		Ldl_recept_b	150..190	CDD:278487
		LY	175..216	CDD:214531
		NHL repeat	181..217	CDD:271320
		NHL repeat	226..253	CDD:271320
		LDL-receptor class B 5	237..276
		FXa_inhibition	286..323	CDD:291342
		Beta-propeller 2	328..589
		LY	353..393	CDD:214531
		LY	397..437	CDD:214531
		LY	438..481	CDD:214531
		LY	483..524	CDD:214531
		LY	525..558	CDD:214531
		FXa_inhibition	592..627	CDD:291342
		Beta-propeller 3	631..890		16/73 (22%)
		LY	656..694	CDD:214531
		LY	697..739	CDD:214531
		LY	740..783	CDD:214531
		LY	783..825	CDD:214531	4/8 (50%)
		LY	827..866	CDD:214531	6/38 (16%)
		FXa_inhibition	893..929	CDD:291342	9/40 (23%)
		Beta-propeller 4	933..1202		44/293 (15%)
		LY	958..998	CDD:214531	7/43 (16%)
		Ldl_recept_b	1069..1110	CDD:278487	7/49 (14%)
		LY	1094..1136	CDD:214531	9/50 (18%)
		FXa_inhibition	1207..1243	CDD:291342	5/35 (14%)
		LDLa	1249..1285	CDD:238060	12/64 (19%)
		LDLa	1288..1322	CDD:238060	12/33 (36%)
		LDLa	1326..1360	CDD:238060	16/34 (47%)
		PPPSP motif A	1487..1493		0/5 (0%)
		PPPSP motif B	1527..1534		4/9 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1556..1613		11/45 (24%)
		PPPSP motif C	1568..1575		3/11 (27%)
		PPPSP motif D	1588..1593		2/2 (100%)
		PPPSP motif E	1603..1610
CG6739	NP_609130.1	CRD_FZ	314..427	CDD:143549	22/121 (18%)
		LDLa	432..464	CDD:238060	11/31 (35%)
		LDLa	470..505	CDD:238060	16/34 (47%)
		LDLa	697..731	CDD:238060	3/3 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900