| Sequence 1: | NP_002327.2 | Gene: | LRP6 / 4040 | HGNCID: | 6698 | Length: | 1613 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_727914.1 | Gene: | Lrp4 / 32552 | FlyBaseID: | FBgn0030706 | Length: | 2009 | Species: | Drosophila melanogaster |
| Alignment Length: | 1274 | Identity: | 505/1274 - (39%) |
|---|---|---|---|
| Similarity: | 758/1274 - (59%) | Gaps: | 57/1274 - (4%) |
- Green bases have known domain annotations that are detailed below.
|
Human 2 GAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIY 66
Human 67 WSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKV 131
Human 132 LFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLDYEEQKL 196
Human 197 YWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREI 261
Human 262 HSDIFSPMDIHAFSQQRQPNATNPCGID----NGGCSHLCLMSPVKPFYQCACPTGVKLLENGKT 322
Human 323 CKDGATELLLLARRTDLR----RISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRA 383
Human 384 IRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEP 448
Human 449 RAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDK 513
Human 514 IEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSA-EREVIIDQLPDLMG 577
Human 578 LKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIV-PEAFLLFSRRAD 641
Human 642 IRRISLETNN-NNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLD 705
Human 706 YPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGK 770
Human 771 PKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPH 834
Human 835 PFGLTQYQDYIYWTDWSRRSI---ERANKTSGQNRTIIQGHLDYVMDI-LVFHSSRQSGW-NECA 894
Human 895 SSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRT-C-SAPTTFLLFSQKSAINRMVIDEQQSPDI 957
Human 958 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQ-EDGSQGFTVVVSSVPSQNLEIQPYDLSI 1021
Human 1022 DIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSP-KIER 1085
Human 1086 AALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDSNIL----Q 1146
Human 1147 PVGLTVFEN---WLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCA 1208
Human 1209 QDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPP 1247 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LRP6 | NP_002327.2 | Beta-propeller 1 | 20..275 | 127/254 (50%) | |
| NHL | 55..272 | CDD:302697 | 109/216 (50%) | ||
| NHL repeat | 55..93 | CDD:271320 | 16/37 (43%) | ||
| LY | 89..127 | CDD:214531 | 20/37 (54%) | ||
| NHL repeat | 97..132 | CDD:271320 | 19/34 (56%) | ||
| NHL repeat | 140..176 | CDD:271320 | 19/35 (54%) | ||
| Ldl_recept_b | 150..190 | CDD:278487 | 21/39 (54%) | ||
| LY | 175..216 | CDD:214531 | 21/40 (53%) | ||
| NHL repeat | 181..217 | CDD:271320 | 19/35 (54%) | ||
| NHL repeat | 226..253 | CDD:271320 | 17/26 (65%) | ||
| LDL-receptor class B 5 | 237..276 | 18/38 (47%) | |||
| FXa_inhibition | 286..323 | CDD:291342 | 20/40 (50%) | ||
| Beta-propeller 2 | 328..589 | 108/265 (41%) | |||
| LY | 353..393 | CDD:214531 | 13/39 (33%) | ||
| LY | 397..437 | CDD:214531 | 19/39 (49%) | ||
| LY | 438..481 | CDD:214531 | 22/42 (52%) | ||
| LY | 483..524 | CDD:214531 | 18/40 (45%) | ||
| LY | 525..558 | CDD:214531 | 10/32 (31%) | ||
| FXa_inhibition | 592..627 | CDD:291342 | 17/34 (50%) | ||
| Beta-propeller 3 | 631..890 | 104/264 (39%) | |||
| LY | 656..694 | CDD:214531 | 12/37 (32%) | ||
| LY | 697..739 | CDD:214531 | 18/41 (44%) | ||
| LY | 740..783 | CDD:214531 | 21/42 (50%) | ||
| LY | 783..825 | CDD:214531 | 15/42 (36%) | ||
| LY | 827..866 | CDD:214531 | 15/41 (37%) | ||
| FXa_inhibition | 893..929 | CDD:291342 | 16/36 (44%) | ||
| Beta-propeller 4 | 933..1202 | 76/277 (27%) | |||
| LY | 958..998 | CDD:214531 | 9/40 (23%) | ||
| Ldl_recept_b | 1069..1110 | CDD:278487 | 16/41 (39%) | ||
| LY | 1094..1136 | CDD:214531 | 13/41 (32%) | ||
| FXa_inhibition | 1207..1243 | CDD:291342 | 15/35 (43%) | ||
| LDLa | 1249..1285 | CDD:238060 | |||
| LDLa | 1288..1322 | CDD:238060 | |||
| LDLa | 1326..1360 | CDD:238060 | |||
| PPPSP motif A | 1487..1493 | ||||
| PPPSP motif B | 1527..1534 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1556..1613 | ||||
| PPPSP motif C | 1568..1575 | ||||
| PPPSP motif D | 1588..1593 | ||||
| PPPSP motif E | 1603..1610 | ||||
| Lrp4 | NP_727914.1 | LDLa | 267..301 | CDD:238060 | |
| LDLa | 306..340 | CDD:238060 | |||
| LDLa | 347..390 | CDD:238060 | |||
| LDLa | 397..431 | CDD:238060 | |||
| LDLa | 442..476 | CDD:238060 | |||
| LDLa | 480..521 | CDD:238060 | |||
| FXa_inhibition | 576..604 | CDD:291342 | 4/11 (36%) | ||
| LY | 634..671 | CDD:214531 | 17/36 (47%) | ||
| NHL | <656..793 | CDD:302697 | 69/137 (50%) | ||
| LY | 680..714 | CDD:214531 | 19/33 (58%) | ||
| NHL repeat | 681..722 | CDD:271320 | 22/40 (55%) | ||
| NHL repeat | 726..760 | CDD:271320 | 18/33 (55%) | ||
| LY | 761..803 | CDD:214531 | 21/41 (51%) | ||
| NHL repeat | 769..793 | CDD:271320 | 13/23 (57%) | ||
| FXa_inhibition | 882..912 | CDD:291342 | 18/31 (58%) | ||
| LY | 946..985 | CDD:214531 | 12/38 (32%) | ||
| NHL | <967..1142 | CDD:302697 | 82/175 (47%) | ||
| LY | 988..1030 | CDD:214531 | 20/41 (49%) | ||
| NHL repeat | 998..1037 | CDD:271320 | 21/38 (55%) | ||
| NHL repeat | 1038..1080 | CDD:271320 | 21/41 (51%) | ||
| NHL repeat | 1084..1119 | CDD:271320 | 19/34 (56%) | ||
| FXa_inhibition | 1185..1220 | CDD:291342 | 17/34 (50%) | ||
| NHL | 1260..>1445 | CDD:302697 | 76/184 (41%) | ||
| NHL repeat | 1260..1296 | CDD:271320 | 10/35 (29%) | ||
| NHL repeat | 1302..1337 | CDD:271320 | 17/34 (50%) | ||
| NHL repeat | 1345..1383 | CDD:271320 | 18/37 (49%) | ||
| FXa_inhibition | <1499..1525 | CDD:291342 | 11/26 (42%) | ||
| LY | 1600..1640 | CDD:214531 | 11/45 (24%) | ||
| LY | 1643..1686 | CDD:214531 | 15/44 (34%) | ||
| LY | 1688..1729 | CDD:214531 | 13/40 (33%) | ||
| FXa_inhibition | 1801..>1825 | CDD:291342 | 13/24 (54%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 56 | 1.000 | Domainoid score | I11038 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG1215 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D121310at2759 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 1 | 0.900 | - | - | OOG6_100345 | |
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 6 | 5.720 | |||||