DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP6 and yl

DIOPT Version :10

Sequence 1:NP_001401173.1 Gene:LRP6 / 4040 HGNCID:6698 Length:1644 Species:Homo sapiens
Sequence 2:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster


Alignment Length:1142 Identity:318/1142 - (27%)
Similarity:468/1142 - (40%) Gaps:226/1142 - (19%)


- Green bases have known domain annotations that are detailed below.


Human   592 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC--IV-----PEAFLLFSRRADIRRISLET 649
            |.|::..||..|.....|.||.|..|:.|..|.:||  :|     .:..||::.:..|..:.|..
  Fly   352 CKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLRE 416

Human   650 NN--NNVAIPLTGVKEASALDFDVTDNRIYWTDI--SLKTISRAFMNGSALEHVVEFGLDYPEGM 710
            :|  |:|......:.:...:.:|  .:.||||:|  ..::|.:|..:||..|.::..|||.||.:
  Fly   417 DNVRNHVYQVAGNLSKVIGVAYD--GSHIYWTNIQNEAESIVKANGDGSNAEILLTSGLDAPEDL 479

Human   711 AVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDR 775
            |||||.:|:|::|.....|.|...||.:..|||.:|:..||:||:.|.:|.|:||:||.||.|.|
  Fly   480 AVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGR 544

Human   776 AAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADD-LPHPFGL 838
            |:||||....:| .|:...||:.:|..::|:||.|.....:::....|..|..:.|. |.||:||
  Fly   545 ASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKHPYGL 609

Human   839 TQYQDYIYWTDWSRRSIERANKTSG-------QNRTIIQGHLDYVMDILVFHSSRQSGWNECASS 896
            ..::|.:||:||:.:|:...:|.||       ::|||...|        ::|.::|.. :.....
  Fly   610 AIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTIYAVH--------IYHPAKQPN-SPHGCE 665

Human   897 NGHCSHLC-LAVP-VGGFVCGCPAHYSLNADNRTCSAPT----------TFLLFSQKSAINRMVI 949
            |..||||| ||.| :||..|.||....|..|:|.|....          ..||..:.:|..|   
  Fly   666 NATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGR--- 727

Human   950 DEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEI 1014
             .|.|....||.    .:..:.|:.::..|...|:.|.:|.:.|.:..:...:|.|::.:.:.  
  Fly   728 -HQVSKSYTLPC----LINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSA-- 785

Human  1015 QPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVV--LKGEQDRPRAVVVNPEKGYMYFTNLQ 1077
                |:.|..||.:||......||.|..|..|...::  ..| |:.|..:.|.|.:||:|.....
  Fly   786 ----LAFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPG-QEVPIGLTVMPAEGYLYVVLKA 845

Human  1078 ERSPKIERAALDGTEREVLFFS---GLSKPIALALDSRLGKLFWADSDLRRIESSDLSEMAFCHV 1139
            :|...|::..|.|...:|..|.   | ...|.|..|.....:||:||||.||..|:.        
  Fly   846 KRHSHIDKIPLSGKGEQVHVFEDDLG-DDDIKLVTDYETQTIFWSDSDLGRISYSNY-------- 901

Human  1140 AQADVELLGSRDPPASASQITEITGANRIVLEDSNILQPVGLTVFEN---W-------LYWIDKQ 1194
                      |.|   .|||..           ..:.:|..|.:..:   |       :||..|.
  Fly   902 ----------RVP---HSQIFR-----------GKLRRPYSLAMVHHDLFWNELGTPRIYWTHKS 942

Human  1195 QQMIEK-IDMTGREGRTKVQ--ARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGT 1256
            .....| ||:..::....:.  ..:|..:.|.......:.: ..|||.|.||||||||:.:|...
  Fly   943 NMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQ-ESHPCQQQNGGCSHICVGEGPYH 1006

Human  1257 TRCSCPMHLVLLQ-DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--- 1317
            :.|.||...|... ...:|.|...|   :|.|.:||  |:.:..||:|..:|.|:|||:||.   
  Fly  1007 SICLCPAGFVYRDAGNRTCVEALDC---EFRCHSGE--CLTMNHRCNGRRDCVDNSDEMNCDEEH 1066

Human  1318 ------VCSESQFQCASG-QCIDGALRCNGDANCQDKSDEKNCEVL-----CLIDQFRCANGQCI 1370
                  :||.:||.|.|| ||:|...||:...:|.|.|||::||..     |.:.|..|.||:|:
  Fly  1067 RRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCEKFDKSKKCHVHQHGCDNGKCV 1131

Human  1371 GKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTVYFICQRMLCPRMKG 1435
            .....||...||.|.||||.|..|....|          |:           |.|         |
  Fly  1132 DSSLVCDGTNDCGDNSDELLCEATSRCEP----------GM-----------FQC---------G 1166

Human  1436 DGETMTNDYVVHGPASVPLGYVPHPSSLSGSL-PGMSR---GKSMISSLSIMG-GSSGPPYDRAH 1495
            .|..:...:...|......|...|...:..|. |.|.|   |:.:..||...| ...|...|..:
  Fly  1167 SGSCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQRCLLGQCLDRSLVCDGHNDCGDKSDELN 1231

Human  1496 V-TGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSN----SPSTHRSYSYRPYSYRH 1555
            . |.:|:.:.|..:..|                      ..:||    .|||.|...        
  Fly  1232 CGTDSSTMNISCAEDQY----------------------QCTSNLKICLPSTVRCNG-------- 1266

Human  1556 FAPPTTPCST--------DVCDSDYAPSRRMTSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAE 1612
                ||.|..        ||| |.|....|.......:.:..|...|.       ...|..||.|
  Fly  1267 ----TTECPRGEDEADCGDVC-SIYEFKCRSGRECIRREFRCDGQKDC-------GDGSDELSCE 1319

Human  1613 -----ENYESCPPSPYTERSYSHHLYPPPPSPCTDSS 1644
                 .|.....|...:.||...||:......|.|.|
  Fly  1320 LEKGHHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLS 1356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP6NP_001401173.1 YncE 1..204 CDD:442618
Beta-propeller 1 20..275
LY 89..127 CDD:214531
Ldl_recept_b 150..191 CDD:459654
LY 175..216 CDD:214531
LY 217..251 CDD:214531
LDL-receptor class B 5 237..276
FXa_inhibition 286..323 CDD:464251
Beta-propeller 2 328..589
LY 353..393 CDD:214531
LY 397..437 CDD:214531
Ldl_recept_b 458..499 CDD:459654
LY 483..524 CDD:214531
LY 525..558 CDD:214531
FXa_inhibition 592..627 CDD:464251 12/34 (35%)
Beta-propeller 3 631..890 91/271 (34%)
YncE <654..813 CDD:442618 62/161 (39%)
LY 697..739 CDD:214531 18/41 (44%)
LY 827..866 CDD:214531 15/46 (33%)
FXa_inhibition 893..929 CDD:464251 17/37 (46%)
LY 958..998 CDD:214531 8/39 (21%)
YncE <968..1075 CDD:442618 27/108 (25%)
LY 1094..1132 CDD:214531 15/40 (38%)
FXa_inhibition 1238..1274 CDD:464251 15/36 (42%)
LDLa 1280..1316 CDD:238060 14/35 (40%)
LDLa 1319..1353 CDD:238060 17/34 (50%)
LDLa 1357..1391 CDD:238060 15/33 (45%)
PPPSP motif A 1518..1524 0/5 (0%)
PPPSP motif B 1558..1565 3/6 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1587..1644 14/61 (23%)
PPPSP motif C 1599..1606 0/6 (0%)
PPPSP motif D 1619..1624 1/4 (25%)
PPPSP motif E 1634..1641 0/6 (0%)
ylNP_996433.1 LDLa 90..124 CDD:238060
LDLa 131..166 CDD:238060
LDLa 184..216 CDD:238060
LDLa 227..262 CDD:238060
LDLa 271..302 CDD:238060
FXa_inhibition 352..387 CDD:464251 12/34 (35%)
Ldl_recept_b 442..483 CDD:459654 17/40 (43%)
LY 466..508 CDD:214531 18/41 (44%)
Ldl_recept_b 529..569 CDD:459654 19/39 (49%)
LY 553..595 CDD:214531 10/41 (24%)
LY 596..637 CDD:214531 15/40 (38%)
FXa_inhibition 669..700 CDD:464251 16/30 (53%)
LY 774..815 CDD:214531 13/46 (28%)
LDLa 1032..1062 CDD:238060 13/31 (42%)
LDLa 1074..1109 CDD:238060 17/34 (50%)
LDLa 1118..1152 CDD:238060 15/33 (45%)
LDLa 1157..1189 CDD:197566 8/61 (13%)
LDLa 1198..1232 CDD:238060 9/33 (27%)
LDLa 1243..1279 CDD:238060 10/69 (14%)
LDLa 1283..1318 CDD:238060 8/42 (19%)
LDLa 1340..1371 CDD:197566 5/17 (29%)
FXa_inhibition 1388..1416 CDD:464251
EGF_CA 1418..1452 CDD:214542
Blue background indicates that the domain is not in the aligned region.

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