DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP6 and lrp-2

DIOPT Version :9

Sequence 1:NP_002327.2 Gene:LRP6 / 4040 HGNCID:6698 Length:1613 Species:Homo sapiens
Sequence 2:NP_491270.2 Gene:lrp-2 / 171981 WormBaseID:WBGene00003072 Length:4858 Species:Caenorhabditis elegans


Alignment Length:1574 Identity:378/1574 - (24%)
Similarity:643/1574 - (40%) Gaps:319/1574 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    21 PLLLYANRRDLRLVDATNGKENATI-VVGGLEDAAAVDFVFSHG---LIYWSDVSEEAIKRTEFN 81
            |.|:|:||.::|::.:   |...:: ::..|.:|.|:||.:...   .|||:|:|.:.|.....:
 Worm  1352 PFLIYSNRHEIRMIQS---KYPGSLPMITNLVNAIALDFKYHQNGSVSIYWTDLSADKIYTGLVD 1413

Human    82 -KTESVQNVVVS-GLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIA 144
             :|...|..:|| |:.:.:|:|.||:...:||.||..:.|:|.:.||:.|..:..|.:...|::|
 Worm  1414 QRTILYQRTIVSYGVFNAEGIAVDWISGNIYWIDSFLDTIQVVSEDGTKRATVINQNMGNARSLA 1478

Human   145 LDPSSGFMYWTDWGEV-PKIERAGMDGSSRFIIIN----SEIYWPNGLTLDYEEQKLYWADAKLN 204
            :|...|||:||||.|. |:||||.:.|::|.||..    ::..||||:.||...:::||||||.:
 Worm  1479 IDVEEGFMFWTDWEESNPRIERASLAGNNRAIIWKISNIAQAGWPNGIALDTIAKRVYWADAKSD 1543

Human   205 FIHKSNLDGTNRQAVVKG--SLPHPFALTLFEDILYWTDWSTHSILACNKYTGEG---LREIHSD 264
            .||....||.:...|.:.  .|.|.|.:.::|..:|::||.|::|...:|:.|..   :..:.:.
 Worm  1544 SIHTITYDGRDHVIVFRDPERLGHCFGIDVYEGHVYFSDWRTNTISKVDKWFGSNVSIIERVATQ 1608

Human   265 IFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATE 329
            .||...:|...|:.|  ..|.|  |...|:.:||.:. |....|.|.......::|  |.| ..:
 Worm  1609 PFSLKIVHRSKQKMQ--IKNSC--DGFKCNGICLNNG-KNKATCQCTNLQSTTDDG--CVD-IQQ 1665

Human   330 LLLLARRTDLRRISLDTPDFTDIVL----QLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFID 390
            :||:|.:..:|..|.|.|......|    |.|:||...:.:     ..:...||....|....:.
 Worm  1666 VLLVATKNGVRGFSTDPPHPHAFPLVSGKQYENIRAVGSFN-----NRLQVLDDYTTHIATVNLT 1725

Human   391 GSGSQFVVT--AQIAHPDGIAVDWVARNLYWTDT--GTDRIEVTRLNGTMRKILI----SEDLEE 447
            |:....|:.  :.:....|:|||.|..:.|.|.:  |...:||...:|..|::|.    |..::.
 Worm  1726 GTADDGVLATGSDLYGVSGMAVDPVVGSTYITLSIDGVGSVEVISADGKSRRVLAESSSSNPMKL 1790

Human   448 PRAIVLDPMVGYMYW-TDWGEIPKIERAALDGSD--RVVLVNTSLGWPNGLALDYDEGKIYW--- 506
            ||.|:.  |...::| .|....|.|...:..|.|  ::.:.:|.|.......:|....||||   
 Worm  1791 PRDILF--MNTKLFWFEDSTSPPSIFSMSAAGDDLKKLKVNSTLLNKFYNPTVDRFYSKIYWISQ 1853

Human   507 -----GDAKTD---KIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSA 563
                 .|.|::   :|::...||....:.|:    ...|..|:|:::           |:..::.
 Worm  1854 GKVIQFDPKSEVVQEIQIPGGDGNVSSIAVD----MTNGDILIGEFI-----------RIANQTT 1903

Human   564 EREVIIDQLPDLMGLKATN-----------VHRV---------IGSNPCAEENGGCSHLCL-YRP 607
            .|.         :|:|.|.           :|..         |.:....:|...|..||| ...
 Worm  1904 IRR---------LGMKGTKAIQRGSVMLVPLHSSIKFFLSTVDITAKNVPDECKKCPSLCLRSSD 1959

Human   608 QGLRCACPIGFELISDMKTCIVPEAFLLF---------------SRRADI----RRISLETNNNN 653
            :..:|.|..||||::.  .|..|:..:.|               |:..|:    |..||.::   
 Worm  1960 KKFQCVCSQGFELVNG--KCRSPDKRVFFATDDGSLHSVGWYKNSKTGDLIQKYRAHSLHSD--- 2019

Human   654 VAIPLTGVKEASALDFDVTDNRIY--------WTDISLKTISRAFMNGSALEHVVEFGLDYPEGM 710
                 .|.|....|..|..::.:|        |         :...||| ..|:|          
 Worm  2020 -----IGKKRILKLVADAKNDLVYVVTRQNEVW---------KCATNGS-FAHIV---------- 2059

Human   711 AVDWLGKNLYWADTGTNRIEVSKLD-------------------------GQH----RQVLVWKD 746
                       ..|.::||....||                         .:|    .||:|..:
 Worm  2060 -----------YSTNSHRIAAITLDRVTGYLLVSARESISPKGFIVLIDPDRHSEAIHQVIVEDE 2113

Human   747 LDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLD 811
            ...|..:|:||.:|.::   |.....|..:...|:|...:| :....:.:.||..:.||.:.|.:
 Worm  2114 DKIPYEIAVDPPKGKLF---WASSSCIKSSNYYGTEAKCIV-SKSSISAIAIDENRSRLCFVDSE 2174

Human   812 TNLIESSNMLGLNRE-VIADDLPHPFG----LTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQG 871
            ...::..:..|.|.: .:|.....|.|    |....|.:|:.|       :.|.:....|.::|.
 Worm  2175 KAAVDCVDYNGNNEQRNVAMFKAQPMGDIVSLVFNGDEMYFFD-------KFNSSGSIVRGLVQQ 2232

Human   872 HLDYVM-DILVFHSSRQS---------------GWNECASSNGHCSHLCLAVPVGGF-----VCG 915
            ....|: |.||....||.               .:..|:::||.|.|||:..|....     .|.
 Worm  2233 DGSVVLKDSLVKVHPRQKIRVIDFDVMDVKSSVLFTACSNNNGGCEHLCITTPSENSPTVRKECL 2297

Human   916 CPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRN-------VRAIDYD 973
            |.  :|...||.:|.:..:|:.|::.::|..:   ..:..|:..|...:.:       :.|:..|
 Worm  2298 CV--HSTRLDNGSCGSSDSFIAFTRFTSIEFL---STKPGDLTSPNKQITSNGCVMSKIGAVTAD 2357

Human   974 PLDKQLYWIDSRQNMIRKAQEDGSQGFTVV---VSSVPSQNLEIQPYDLSIDIYSRYIYWTCEAT 1035
            ....::|:.|..:..|.....||: |..|:   |..|||     ..||   ::::...:......
 Worm  2358 ATRGRIYFADYDKFRITAVNFDGT-GCVVIAEDVGVVPS-----MAYD---EVHTELYFVRANPA 2413

Human  1036 NVINVTRLDGRSVG-------VVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTER 1093
            ::..:...|.....       |:....:||||.:.::|.:..::|||.......|||....|.:|
 Worm  2414 SIWRINVADNNLESYPTEPKIVLTLTVRDRPRHIAIHPCRMLLFFTNNAITGSVIERVYFSGFKR 2478

Human  1094 EVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR-IVLEDSNI--LQPVGLTVFEN 1155
            :.:....|.....|.:|....||:::||...:|...|..|::| :|:.:::|  :.|..|:::::
 Worm  2479 DQIVQEDLHDLRGLTIDLDSEKLYFSDSKDFKISRCDFDGSHRELVVSNTDIPSIHPFELSIYDD 2543

Human  1156 WLY---WIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIH---AVKELNLQEYRQHPCAQDNGGC 1214
            .:.   |:.:....:.||  ||.:.|     .|.:.:|:.   .|.:...:......||.:...|
 Worm  2544 EIIFTDWVRRSVVGVNKI--TGSDNR-----NINRATDVPVGLVVVDTKREYCTSDACADNELKC 2601

Human  1215 SHICLVKGDGTTRCSCPMHLVLLQDELSC-GE--PPTCSPQQFTCFTGEIDCIPVAWRCDGFTEC 1276
            ...|.:..:|...|:|.....|..|..:| ||  ...|:..:|.|...: .||.....||.:.:|
 Worm  2602 EDYCRLMANGQASCACNGERRLNSDNRTCTGEFDGKKCAENEFKCLHSD-RCIRYEDTCDRYNDC 2665

Human  1277 E--DHSDELNCP--VCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQ 1337
            .  |..|...|.  ||....|.|.:|.||.....||...:|.:.:||.||  .|..::|||.:|.
 Worm  2666 PMFDDEDTKYCSTRVCRPGYFNCGNGLCIPEQKVCNRINDCANFADESNC--TCNENEFRCQSGA 2728

Human  1338 CIGKHKKCDHNVDCSDKSDELDCYPTEEPAP----QATNTVGSVIGVIVTIFVSGTVYFICQRML 1398
            ||....:|:|..||:|.|||:.|       |    .|.|..| :.|:|.....|..::       
 Worm  2729 CIPSKARCNHMQDCNDASDEIGC-------PFRNCSALNEFG-MTGLINCATTSQCIH------- 2778

Human  1399 CPRMKGDGETMTND 1412
             |..|.||   |||
 Worm  2779 -PSWKCDG---TND 2788

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP6NP_002327.2 Beta-propeller 1 20..275 88/269 (33%)
NHL 55..272 CDD:302697 78/231 (34%)
NHL repeat 55..93 CDD:271320 13/42 (31%)
LY 89..127 CDD:214531 14/38 (37%)
NHL repeat 97..132 CDD:271320 13/34 (38%)
NHL repeat 140..176 CDD:271320 18/36 (50%)
Ldl_recept_b 150..190 CDD:278487 21/44 (48%)
LY 175..216 CDD:214531 18/44 (41%)
NHL repeat 181..217 CDD:271320 16/35 (46%)
NHL repeat 226..253 CDD:271320 8/26 (31%)
LDL-receptor class B 5 237..276 10/41 (24%)
FXa_inhibition 286..323 CDD:291342 9/36 (25%)
Beta-propeller 2 328..589 64/306 (21%)
LY 353..393 CDD:214531 9/43 (21%)
LY 397..437 CDD:214531 12/43 (28%)
LY 438..481 CDD:214531 12/49 (24%)
LY 483..524 CDD:214531 12/51 (24%)
LY 525..558 CDD:214531 4/32 (13%)
FXa_inhibition 592..627 CDD:291342 11/35 (31%)
Beta-propeller 3 631..890 59/335 (18%)
LY 656..694 CDD:214531 7/45 (16%)
LY 697..739 CDD:214531 8/70 (11%)
LY 740..783 CDD:214531 11/42 (26%)
LY 783..825 CDD:214531 7/41 (17%)
LY 827..866 CDD:214531 8/42 (19%)
FXa_inhibition 893..929 CDD:291342 13/40 (33%)
Beta-propeller 4 933..1202 59/294 (20%)
LY 958..998 CDD:214531 8/46 (17%)
Ldl_recept_b 1069..1110 CDD:278487 10/40 (25%)
LY 1094..1136 CDD:214531 10/41 (24%)
FXa_inhibition 1207..1243 CDD:291342 9/35 (26%)
LDLa 1249..1285 CDD:238060 10/37 (27%)
LDLa 1288..1322 CDD:238060 11/33 (33%)
LDLa 1326..1360 CDD:238060 15/33 (45%)
PPPSP motif A 1487..1493
PPPSP motif B 1527..1534
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1556..1613
PPPSP motif C 1568..1575
PPPSP motif D 1588..1593
PPPSP motif E 1603..1610
lrp-2NP_491270.2 LDLa 80..119 CDD:197566
LDLa 130..162 CDD:197566
LY 668..702 CDD:214531
LY 707..758 CDD:214531
LY 759..801 CDD:214531
LDLa 968..1000 CDD:197566
LDLa 1013..1047 CDD:238060
LDLa 1053..1087 CDD:238060
LDLa 1098..1129 CDD:238060
LDLa 1144..1175 CDD:238060
LDLa 1182..1216 CDD:238060
FXa_inhibition 1276..1305 CDD:291342
LY 1421..1463 CDD:214531 15/41 (37%)
LY 1465..1508 CDD:214531 18/42 (43%)
LY 1521..1555 CDD:214531 16/33 (48%)
LY 2480..2521 CDD:214531 10/40 (25%)
LDLa 2681..2715 CDD:238060 11/33 (33%)
LDLa 2717..2751 CDD:238060 15/33 (45%)
LDLa <2774..2798 CDD:238060 8/26 (31%)
LDLa 2819..2851 CDD:238060
LDLa 2856..2891 CDD:238060
LDLa 2904..2938 CDD:238060
LDLa 2988..3020 CDD:197566
LY 3231..3270 CDD:214531
Ldl_recept_b 3296..3336 CDD:278487
LY 3319..3362 CDD:214531
LY 3363..3404 CDD:214531
LDLa 3481..3514 CDD:197566
LDLa 3574..3609 CDD:238060
LDLa 3614..3649 CDD:197566
LDLa 3659..3693 CDD:238060
LDLa 3881..3912 CDD:238060
LY 4084..4125 CDD:214531
LY 4139..4181 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 1 1.100 - - O PTHR24270
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.810

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