Sequence 1: | NP_002327.2 | Gene: | LRP6 / 4040 | HGNCID: | 6698 | Length: | 1613 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_491270.2 | Gene: | lrp-2 / 171981 | WormBaseID: | WBGene00003072 | Length: | 4858 | Species: | Caenorhabditis elegans |
Alignment Length: | 1574 | Identity: | 378/1574 - (24%) |
---|---|---|---|
Similarity: | 643/1574 - (40%) | Gaps: | 319/1574 - (20%) |
- Green bases have known domain annotations that are detailed below.
Human 21 PLLLYANRRDLRLVDATNGKENATI-VVGGLEDAAAVDFVFSHG---LIYWSDVSEEAIKRTEFN 81
Human 82 -KTESVQNVVVS-GLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIA 144
Human 145 LDPSSGFMYWTDWGEV-PKIERAGMDGSSRFIIIN----SEIYWPNGLTLDYEEQKLYWADAKLN 204
Human 205 FIHKSNLDGTNRQAVVKG--SLPHPFALTLFEDILYWTDWSTHSILACNKYTGEG---LREIHSD 264
Human 265 IFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATE 329
Human 330 LLLLARRTDLRRISLDTPDFTDIVL----QLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFID 390
Human 391 GSGSQFVVT--AQIAHPDGIAVDWVARNLYWTDT--GTDRIEVTRLNGTMRKILI----SEDLEE 447
Human 448 PRAIVLDPMVGYMYW-TDWGEIPKIERAALDGSD--RVVLVNTSLGWPNGLALDYDEGKIYW--- 506
Human 507 -----GDAKTD---KIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSA 563
Human 564 EREVIIDQLPDLMGLKATN-----------VHRV---------IGSNPCAEENGGCSHLCL-YRP 607
Human 608 QGLRCACPIGFELISDMKTCIVPEAFLLF---------------SRRADI----RRISLETNNNN 653
Human 654 VAIPLTGVKEASALDFDVTDNRIY--------WTDISLKTISRAFMNGSALEHVVEFGLDYPEGM 710
Human 711 AVDWLGKNLYWADTGTNRIEVSKLD-------------------------GQH----RQVLVWKD 746
Human 747 LDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLD 811
Human 812 TNLIESSNMLGLNRE-VIADDLPHPFG----LTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQG 871
Human 872 HLDYVM-DILVFHSSRQS---------------GWNECASSNGHCSHLCLAVPVGGF-----VCG 915
Human 916 CPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRN-------VRAIDYD 973
Human 974 PLDKQLYWIDSRQNMIRKAQEDGSQGFTVV---VSSVPSQNLEIQPYDLSIDIYSRYIYWTCEAT 1035
Human 1036 NVINVTRLDGRSVG-------VVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTER 1093
Human 1094 EVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR-IVLEDSNI--LQPVGLTVFEN 1155
Human 1156 WLY---WIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIH---AVKELNLQEYRQHPCAQDNGGC 1214
Human 1215 SHICLVKGDGTTRCSCPMHLVLLQDELSC-GE--PPTCSPQQFTCFTGEIDCIPVAWRCDGFTEC 1276
Human 1277 E--DHSDELNCP--VCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQ 1337
Human 1338 CIGKHKKCDHNVDCSDKSDELDCYPTEEPAP----QATNTVGSVIGVIVTIFVSGTVYFICQRML 1398
Human 1399 CPRMKGDGETMTND 1412 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
LRP6 | NP_002327.2 | Beta-propeller 1 | 20..275 | 88/269 (33%) | |
NHL | 55..272 | CDD:302697 | 78/231 (34%) | ||
NHL repeat | 55..93 | CDD:271320 | 13/42 (31%) | ||
LY | 89..127 | CDD:214531 | 14/38 (37%) | ||
NHL repeat | 97..132 | CDD:271320 | 13/34 (38%) | ||
NHL repeat | 140..176 | CDD:271320 | 18/36 (50%) | ||
Ldl_recept_b | 150..190 | CDD:278487 | 21/44 (48%) | ||
LY | 175..216 | CDD:214531 | 18/44 (41%) | ||
NHL repeat | 181..217 | CDD:271320 | 16/35 (46%) | ||
NHL repeat | 226..253 | CDD:271320 | 8/26 (31%) | ||
LDL-receptor class B 5 | 237..276 | 10/41 (24%) | |||
FXa_inhibition | 286..323 | CDD:291342 | 9/36 (25%) | ||
Beta-propeller 2 | 328..589 | 64/306 (21%) | |||
LY | 353..393 | CDD:214531 | 9/43 (21%) | ||
LY | 397..437 | CDD:214531 | 12/43 (28%) | ||
LY | 438..481 | CDD:214531 | 12/49 (24%) | ||
LY | 483..524 | CDD:214531 | 12/51 (24%) | ||
LY | 525..558 | CDD:214531 | 4/32 (13%) | ||
FXa_inhibition | 592..627 | CDD:291342 | 11/35 (31%) | ||
Beta-propeller 3 | 631..890 | 59/335 (18%) | |||
LY | 656..694 | CDD:214531 | 7/45 (16%) | ||
LY | 697..739 | CDD:214531 | 8/70 (11%) | ||
LY | 740..783 | CDD:214531 | 11/42 (26%) | ||
LY | 783..825 | CDD:214531 | 7/41 (17%) | ||
LY | 827..866 | CDD:214531 | 8/42 (19%) | ||
FXa_inhibition | 893..929 | CDD:291342 | 13/40 (33%) | ||
Beta-propeller 4 | 933..1202 | 59/294 (20%) | |||
LY | 958..998 | CDD:214531 | 8/46 (17%) | ||
Ldl_recept_b | 1069..1110 | CDD:278487 | 10/40 (25%) | ||
LY | 1094..1136 | CDD:214531 | 10/41 (24%) | ||
FXa_inhibition | 1207..1243 | CDD:291342 | 9/35 (26%) | ||
LDLa | 1249..1285 | CDD:238060 | 10/37 (27%) | ||
LDLa | 1288..1322 | CDD:238060 | 11/33 (33%) | ||
LDLa | 1326..1360 | CDD:238060 | 15/33 (45%) | ||
PPPSP motif A | 1487..1493 | ||||
PPPSP motif B | 1527..1534 | ||||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1556..1613 | ||||
PPPSP motif C | 1568..1575 | ||||
PPPSP motif D | 1588..1593 | ||||
PPPSP motif E | 1603..1610 | ||||
lrp-2 | NP_491270.2 | LDLa | 80..119 | CDD:197566 | |
LDLa | 130..162 | CDD:197566 | |||
LY | 668..702 | CDD:214531 | |||
LY | 707..758 | CDD:214531 | |||
LY | 759..801 | CDD:214531 | |||
LDLa | 968..1000 | CDD:197566 | |||
LDLa | 1013..1047 | CDD:238060 | |||
LDLa | 1053..1087 | CDD:238060 | |||
LDLa | 1098..1129 | CDD:238060 | |||
LDLa | 1144..1175 | CDD:238060 | |||
LDLa | 1182..1216 | CDD:238060 | |||
FXa_inhibition | 1276..1305 | CDD:291342 | |||
LY | 1421..1463 | CDD:214531 | 15/41 (37%) | ||
LY | 1465..1508 | CDD:214531 | 18/42 (43%) | ||
LY | 1521..1555 | CDD:214531 | 16/33 (48%) | ||
LY | 2480..2521 | CDD:214531 | 10/40 (25%) | ||
LDLa | 2681..2715 | CDD:238060 | 11/33 (33%) | ||
LDLa | 2717..2751 | CDD:238060 | 15/33 (45%) | ||
LDLa | <2774..2798 | CDD:238060 | 8/26 (31%) | ||
LDLa | 2819..2851 | CDD:238060 | |||
LDLa | 2856..2891 | CDD:238060 | |||
LDLa | 2904..2938 | CDD:238060 | |||
LDLa | 2988..3020 | CDD:197566 | |||
LY | 3231..3270 | CDD:214531 | |||
Ldl_recept_b | 3296..3336 | CDD:278487 | |||
LY | 3319..3362 | CDD:214531 | |||
LY | 3363..3404 | CDD:214531 | |||
LDLa | 3481..3514 | CDD:197566 | |||
LDLa | 3574..3609 | CDD:238060 | |||
LDLa | 3614..3649 | CDD:197566 | |||
LDLa | 3659..3693 | CDD:238060 | |||
LDLa | 3881..3912 | CDD:238060 | |||
LY | 4084..4125 | CDD:214531 | |||
LY | 4139..4181 | CDD:214531 | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG1215 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 1 | 0.900 | - | - | OOG6_100345 | |
Panther | 1 | 1.100 | - | - | O | PTHR24270 |
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 1 | 1.000 | - | - | ||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
5 | 4.810 |