DRSC/TRiP Functional Genomics Resources

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Protein Alignment S1P and MBTPS1

DIOPT Version :10

Sequence 1:NP_649337.2 Gene:S1P / 40399 FlyBaseID:FBgn0037105 Length:1012 Species:Drosophila melanogaster
Sequence 2:NP_003782.1 Gene:MBTPS1 / 8720 HGNCID:15456 Length:1052 Species:Homo sapiens


Alignment Length:1059 Identity:476/1059 - (44%)
Similarity:641/1059 - (60%) Gaps:151/1059 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 FKTAVVPNEFIVHFHSKYFAPVRESYIAAKLLGSNVTNWRIVPRLNLAWQYPSDFDILRVCDGYE 83
            |.:.||..|:||.|:..:.|..|.|:|::.|..|.|.||||:||.|.:..|||||:::::.:..:
Human    47 FSSTVVEYEYIVAFNGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQK 111

  Fly    84 SSSEFIIERLQTHPSVKAVVPQRSVRRILNYDAYSNLT--------------------------- 121
            :.    :..|:.||::|.|.|||.|.|.|.| |.|:.|                           
Human   112 AG----LLTLEDHPNIKRVTPQRKVFRSLKY-AESDPTVPCNETRWSQKWQSSRPLRRASLSLGS 171

  Fly   122 -YIH---RHPQGVLRNRNPNNDRHRQLCSVLHANILWKLGITGKGVKVAIFDTGLTKNHPHFRNV 182
             :.|   ||....|....|     ||:...|.|::||::|.||..|:||:|||||::.||||:||
Human   172 GFWHATGRHSSRRLLRAIP-----RQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNV 231

  Fly   183 KERTNWTNEKSLDDRVSHGTFVAGVIASSRECLGFAPDADLYIFKVFTNSQVSYTSWFLDAFNYA 247
            |||||||||::|||.:.|||||||||||.|||.||||||:|:||:||||:|||||||||||||||
Human   232 KERTNWTNERTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYA 296

  Fly   248 IYRKINILNLSIGGPDFMDSPFVEKVLELSANNVIMISAAGNDGPLYGTLNNPGDQSDVVGVGGI 312
            |.:||::||||||||||||.|||:||.||:||||||:||.|||||||||||||.||.||:|||||
Human   297 ILKKIDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGGI 361

  Fly   313 QFDDKIAKFSSRGMTTWELPLGYGRMGLDIVTYGSQVEGSDVRKGCRRLSGTSVSSPVVAGAAAL 377
            .|:|.||:||||||||||||.|||||..||||||:.|.||.|:.|||.||||||:|||||||..|
Human   362 DFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVVAGAVTL 426

  Fly   378 LISGAFQKIDYINPASLKQVLIEGAEKLPHYNMFEQGAGKLNLLKSMQLLLSYKPKITLIPAYLD 442
            |:| ..||.:.:||||:||.||..|.:||..||||||.|||:||::.|:|.||||:.:|.|:|:|
Human   427 LVS-TVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKPQASLSPSYID 490

  Fly   443 FTQ-NYMWPYSSQPLYYGSSVAIANVTILNGISVTSHIVGIPKWIPDFENQGQFLQVSAQVSPIV 506
            .|: .|||||.|||:|||....:.|||||||:.||..||..|.|.|.....|..::|:...|.::
Human   491 LTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQNGDNIEVAFSYSSVL 555

  Fly   507 WPWTGWMSVFIAVKKEGENFEGVCKGSITLVLESFKQTTNET---HVTEVDFPLTIKVTPKPPRN 568
            |||:|::::.|:|.|:..::||:.:|.:.:.:.|..:|.::.   ..:.|..|:.:|:.|.|||:
Human   556 WPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAEQTSTVKLPIKVKIIPTPPRS 620

  Fly   569 KRILWDQYHSLRYPPRYIPRDDLKVKLDPLDWRADHIHTNFRDMYTHLRNVGYYIDVLREPFTCF 633
            ||:||||||:|||||.|.|||:|::|.|||||..|||||||||||.|||::||:::||..|||||
Human   621 KRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTNFRDMYQHLRSMGYFVEVLGAPFTCF 685

  Fly   634 NASDYGALLIVDPERGFGDEEINALQENVYKRGLNVVVFGDWYNTTVMKKIKFFDENTRQWWTPD 698
            :||.||.||:||.|..:..|||..|:.:| ..||::|:|.|||||:||:|:||:||||||||.||
Human   686 DASQYGTLLMVDSEEEYFPEEIAKLRRDV-DNGLSLVIFSDWYNTSVMRKVKFYDENTRQWWMPD 749

  Fly   699 TGGANIPALNDLLKPFGIAFGDFVGEGHFKLGDHSMYYASGATIVKFPMNPGDIIVGTKLNDQGL 763
            ||||||||||:||..:.:.|.|.:.||.|.|.:|.||||||.:|.|||.:  .:::.....||||
Human   750 TGGANIPALNELLSVWNMGFSDGLYEGEFTLANHDMYYASGCSIAKFPED--GVVITQTFKDQGL 812

  Fly   764 SIINSKTPSKVAKLDVPIFGMFQTKANSIQSNEEIVVNAESNLAEAIPTDYSTFKNRVLLLRTKQ 828
            .::..:|   ....:|||.|::|                       ||.:               
Human   813 EVLKQET---AVVENVPILGLYQ-----------------------IPAE--------------- 836

  Fly   829 RSISFAKSNNHETKNEGRIAVYGDSNCLDSTHLEKACYWLLITFLDFAIN-------SH------ 880
                          ..|||.:||||||||.:|.:|.|:|||...|.:...       ||      
Human   837 --------------GGGRIVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQR 887

  Fly   881 -------------KSSLLQNLNRITEFHKLERAPLPLRISQSIIKSRSQDNNCEQFKWLAPTKQN 932
                         :.:.|...:::.|.|..:..|.||..             |.:..|..|...|
Human   888 PPSGAGSVTPERMEGNHLHRYSKVLEAHLGDPKPRPLPA-------------CPRLSWAKPQPLN 939

  Fly   933 NA-------EERKSSI-IDVTILENEEHEINLIKNLLGEEIAKLGQNNDYLTGMQSADSLMTPII 989
            ..       .::..|| :|..:|.|.......::.|...|..........:.|..:.:...|..:
Human   940 ETAPSNLWKHQKLLSIDLDKVVLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPV 1004

  Fly   990 FLIILSLIVIMLFVLFLKR 1008
            |..:.:::|:..||:.:.:
Human  1005 FAFLGAMVVLAFFVVQINK 1023

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
S1PNP_649337.2 Peptidases_S8_SKI-1_like 154..407 CDD:173805 186/252 (74%)
DUF4350 610..754 CDD:464118 83/143 (58%)
MBTPS1NP_003782.1 Peptidases_S8_SKI-1_like 203..455 CDD:173805 186/252 (74%)
DUF4350 651..>726 CDD:464118 43/75 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 877..899 2/21 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1027..1052
Blue background indicates that the domain is not in the aligned region.

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