Protein Alignment S1P and TPP2

DIOPT Version :10

• Sequence 1: NP_649337.2
• Gene: S1P / 40399
• FlyBaseID: FBgn0037105
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: NP_193817.2
• Gene: TPP2 / 827833
• AraportID: AT4G20850
• Length: 1380
• Species: Arabidopsis thaliana
• Alignment Length: 1026
• Identity: 200/1026 - (19%)
• Similarity: 350/1026 - (34%)
• Gaps: 339/1026 - (33%)

  Fly    33 HSKYFAPVRESYIAAKLLGSNVTN---WRIVPRLNLAWQYPSDFDILRVCDG-YESSSEFIIERL 93
            :|.:..|..|..:.:||:....|:   .|:......:|...:..:|.:..:. |:..
plant   202 NSSWKNPTGEWRVGSKLVYQLFTDDLTSRVKKERRKSWDEKNQEEIAKAVNNLYDFD-------- 258

  Fly    94 QTHPSVKAVVPQRSVRRILNYDAYSNLTYIHRHPQGVLRNRNPNNDRHRQLCSVLHANILWKLGI 158
            |.|..|:....:::     ..|..|.:.::.:..           |::.....|:.| ::|.
plant   259 QKHSKVEDAKLKKT-----REDLQSKVDFLKKQA-----------DKYEDKGPVIDA-VVWH--- 303

  Fly   159 TGKGVKVAIFDTGLTKNHP---HFRNVKERTNWTNEKS------LD------------------- 195
            .|:..:||: ||...:..|   ...:....||:..|:.      ||
plant   304 DGEVWRVAL-DTQSLEEDPDSGKLADFSPLTNYRIERKYGVFSRLDACSFVANVYDEGKVLSIVT 367

  Fly   196 DRVSHGTFVAGVIAS--SRECL--GFAPDADLYIFKVFTN--SQVSYTSWFLDAFNYAIYRKINI 254
            |...|||.|||:..:  ..|.|  |.||.|.:...|:..:  ..:...:....|...|:....::
plant   368 DSSPHGTHVAGIATAHHPEEHLLNGVAPGAQIISCKIGDSRLGSMETGTGLTRALIAALEHNCDL 432

  Fly   255 LNLSIGGPDFMD--SPFVEKVLE-LSANNVIMISAAGNDGPLYGTLNNP-GDQSDVVGVG----- 310
            :|:|.|.|..:.  ..||:.|.| ::...:|.:|:|||.||...|:..| |..|.::|||
plant   433 VNMSYGEPALLPDYGRFVDLVTEAVNKRRLIFVSSAGNSGPALTTVGAPGGTTSSIIGVGAYVSP 497

  Fly   311 ---------------GIQFDDKIAKFSSRGMTTWELPLGYGRMGLDIVTYGSQVEGSDVRKGCRR 360
                           |:::     .:||||      |...|.:|:.|...|..|.........||
plant   498 AMAAGAHSVVEPPSEGLEY-----TWSSRG------PTSDGDLGVCISAPGGAVAPVPTWTLQRR 551

  Fly   361 --LSGTSVSSPVVAGAAALLISGAFQKIDYINPASLKQVLIEGAE---KLPHYNMFEQGAGKLNL 420
              ::|||::||...||.|||:|....:...::|.|:::.|...:.   .||. :....|.|.:.:
plant   552 MLMNGTSMASPSACGAIALLLSAMKAEGIPVSPYSVRRALENTSTPVGDLPE-DKLTTGQGLMQV 615

  Fly   421 LKSMQLLLSYKPKITLIPAYLDFTQNYMWPYSSQP-LYYGSSVAIANVTILNGISVTSHIVGIPK 484
            .|:.:              ||...|:|       | ::|...|.::..||..
plant   616 DKAYE--------------YLKQFQDY-------PCVFYQIKVNLSGKTIPT------------- 646

  Fly   485 WIPDFENQGQFLQVSAQVSPIVWPWTGWMSVFIAVKKEGENFEGVCKGSITLVLESFKQTTNETH 549
                  ::|.:|                        :||.    .|:.|
plant   647 ------SRGIYL------------------------REGT----ACRQS---------------- 661

  Fly   550 VTEVDFPLTIKVTPKPPRNKRILWDQYHSLRYPPRYIPRDDLKVKLDPLDWRADHIHTNFRDM-- 612
             ||    .||:|.||           :|.        ...:|| :|.|.: ....:|:....:
plant   662 -TE----WTIQVDPK-----------FHE--------GASNLK-ELVPFE-ECLELHSTDEGVVR 700

  Fly   613 ---YTHLRNVGYYIDVLREPFTCFNASDYGALLIVD---PERG---------------------F 650
               |..|.|.|...:|:.:|....:...|..:..:|   ||||                     .
plant   701 VPDYLLLTNNGRGFNVVVDPTNLGDGVHYFEVYGIDCKAPERGPLFRIPVTIIIPKTVANQPPVI 765

  Fly   651 GDEEINALQENVYKRGLNVVVFGDWYNTTVMKKIKFFDENTR---------------QWWTPDTG 700
            ..::::.:..::.:|.:.|.....|...|:  :...||...|               :|.:..|.
plant   766 SFQQMSFISGHIERRYIEVPHGATWAEATM--RTSGFDTTRRFYIDTLQVCPLRRPIKWESAPTF 828

  Fly   701 GANIPALNDLLKP------FGIAFGDFVGEGHFKLGDHSMYYASGATIVKFPMNPGDIIVGTKLN 759
            .:  |:....:.|      ..:|...|...|   ||...      .|||.|.:.    ..|..::
plant   829 AS--PSAKSFVFPVVSGQTMELAIAQFWSSG---LGSRE------PTIVDFEIE----FHGVGVD 878

  Fly   760 DQGLSIINSKTPSKVAKLDVPIFGMFQTKANSIQSNEEIVVNAESNLAEA--IPTD-----YSTF 817
            .:.|.:..|:.|.||             :|.::.::|::|..|..|....  .|.|     .||.
plant   879 KEELLLDGSEAPIKV-------------EAEALLASEKLVPIAVLNKIRVPYQPIDAQLKTLSTG 930

  Fly   818 KNRVL-----LLRTKQRSISFAKS----------NN--HETKNEGRIAVYGDSN---------CL 856
            ::|:|     |..|.........|          ||  ::||.|.:..:..|:|         ..
plant   931 RDRLLSGKQILALTLTYKFKLEDSAEVKPYIPLLNNRIYDTKFESQFFMISDTNKRVYAMGDVYP 995

  Fly   857 DSTHLEKACYWLLITFLDFAINSHKSSLLQNLNRITEFHKLERAPLPLRIS 907
            :|:.|.|..|     .|...:......||:.|.::|.|  :||....:|::
plant   996 ESSKLPKGEY-----KLQLYLRHENVELLEKLKQLTVF--IERNMGEIRLN 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S1P	NP_649337.2	Peptidases_S8_SKI-1_like	154..407	CDD:173805	78/315 (25%)
		DUF4350	610..754	CDD:464118	32/193 (17%)
TPP2	NP_193817.2	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	116..598	CDD:173796	95/435 (22%)
		TPPII	897..1080	CDD:463636	33/150 (22%)