DRSC/TRiP Functional Genomics Resources

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Protein Alignment S1P and PCSK4

DIOPT Version :10

Sequence 1:NP_649337.2 Gene:S1P / 40399 FlyBaseID:FBgn0037105 Length:1012 Species:Drosophila melanogaster
Sequence 2:XP_011526387.1 Gene:PCSK4 / 54760 HGNCID:8746 Length:782 Species:Homo sapiens


Alignment Length:643 Identity:123/643 - (19%)
Similarity:203/643 - (31%) Gaps:261/643 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    94 QTHPSVKAVVPQRSVR-RILNYDAYSNL-------TYIHRHPQGVLRNRNP--------NNDRHR 142
            :|.|..|::..:.:.| |..|:.|...|       |...|..:.|:...:|        |::...
Human    98 KTRPGPKSIQQEEAGRPRYGNHGACQGLVQWFQQQTLQRRVKRSVVVPTDPWFSKQWYMNSEAQP 162

  Fly   143 QLCSVLHANILWKLGITGKGVKVAIFDTGLTKNHPHFRNVKERTNWTN----------------- 190
            .| |:|.|   |..|::|:|:.|::.|.|:.|:||..        |.|                 
Human   163 DL-SILQA---WSQGLSGQGIVVSVLDDGIEKDHPDL--------WANYDPLASYDFNDYDPDPQ 215

  Fly   191 ---EKSLDDRVSHGTFVAGVIASSRECLGFAPDADLYIFKVFTNSQVSYTSWFLDAFNYAIYRKI 252
               ..|.::|  |||..||.:|:...             ..|....|::                
Human   216 PRYTPSKENR--HGTRCAGEVAAMAN-------------NGFCGVGVAF---------------- 249

  Fly   253 NILNLSIGGPDFMDSPFVEKV----LELSANNVIMISAAGN--------DGPLYGTLNNPGDQSD 305
               |..|||...:|....:.:    |.|...::.:.||:..        |||  |.|.....:..
Human   250 ---NARIGGVRMLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGP--GILTREAFRRG 309

  Fly   306 VV--------------GVGGIQFDD-------------KIAKFSSRGMTTWELPLGYGRMGLDIV 343
            |.              |.||:.:|:             .:...:.:|...|     |.......:
Human   310 VTKGRGGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPW-----YSEACASTL 369

  Fly   344 --TYGS------QVEGSDVRKGCR-RLSGTSVSSPVVAGAAALLISGAFQKIDYINPASLKQVLI 399
              ||.|      |:..:|:..||. :.:|||.|:|:.||..||.:..        ||        
Human   370 TTTYSSGVATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEA--------NP-------- 418

  Fly   400 EGAEKLPHYNMFEQGAGKLNLLKSMQLLLSYKPKITLIPAYL---DFTQNYMWPYSSQPLYYGSS 461
                              ....:.||.|:....|    ||:|   |:..|.:....|....||  
Human   419 ------------------FLTWRDMQHLVVRASK----PAHLQAEDWRTNGVGRQVSHHYGYG-- 459

  Fly   462 VAIANVTILNGISVTSHIVGIPKWIPDFENQGQFLQVSAQVSPIVWPWTGWMSVFIAVKKEGENF 526
              :.:..:|...:.|        |:|....:...::|.::.:||:        ..|.::   ||.
Human   460 --LLDAGLLVDTART--------WLPTQPQRKCAVRVQSRPTPIL--------PLIYIR---ENV 503

  Fly   527 EGVCKGSITLVLESFKQTTNETHVTEVDFPLTIKVTPKPPRNKRILWDQYHSLRYPPRYIPRDDL 591
             ..|.|    :..|.:.      :..|...||:.                        |..|.||
Human   504 -SACAG----LHNSIRS------LEHVQAQLTLS------------------------YSRRGDL 533

  Fly   592 KVKL-DPLDWRADHI-----------HTNFRDMYTH-------------LRNVGYYID 624
            ::.| .|:..|:..:           :.|:..|.||             |.|.|||.:
Human   534 EISLTSPMGTRSTLVAIRPLDVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKGYYFN 591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
S1PNP_649337.2 Peptidases_S8_SKI-1_like 154..407 CDD:173805 62/320 (19%)
DUF4350 610..754 CDD:464118 8/28 (29%)
PCSK4XP_011526387.1 S8_pro-domain 37..140 CDD:465126 10/41 (24%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 145..434 CDD:173789 71/375 (19%)
P_proprotein 516..600 CDD:460225 19/100 (19%)
VSP 619..>710 CDD:146106
FU 674..711 CDD:214589
Blue background indicates that the domain is not in the aligned region.

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