Protein Alignment S1P and Furin

DIOPT Version :10

• Sequence 1: NP_649337.2
• Gene: S1P / 40399
• FlyBaseID: FBgn0037105
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: NP_062204.2
• Gene: Furin / 54281
• RGDID: 3274
• Length: 793
• Species: Rattus norvegicus
• Alignment Length: 719
• Identity: 142/719 - (19%)
• Similarity: 233/719 - (32%)
• Gaps: 242/719 - (33%)

  Fly     7 LFIISA-----ICSLDAFKTAVVPNEFIVHFHSKYFAPVRESYIAAK--------LLGSNVTNW- 57
            |::::|     :.:.:|....:..|.:.||...   .|.....:|.|        :.|.....|
  Rat     8 LWVVAAAGALVLLAAEARGQKIFTNTWAVHISG---GPAVADSVARKHGFHNLGQIFGDYYHFWH 69

  Fly    58 RIVPRLNLAWQYPSDFDILRVCDGYESSSEFIIERLQTHPSVK----AVVPQRSVRRILNYDAYS 118
            |.|.:.:|:...|..                  .|||..|.||    .|..||:.|     |.|.
  Rat    70 RAVTKRSLSPHRPRH------------------SRLQREPQVKWLEQQVAKQRAKR-----DVYQ 111

  Fly   119 NLTYIHRHPQGVLRNRNPNNDRHRQLCSV----LHANILWKLGITGKGVKVAIFDTGLTKNHPHF 179
            ..|             :|...:...|..|    |:....|..|.||:|:.|:|.|.|:.||||..
  Rat   112 EPT-------------DPKFPQQWYLSGVTQRDLNVKEAWAQGFTGRGIVVSILDDGIEKNHPDL 163

  Fly   180 R-NVKERTNW-TNEKSLDDRV--------SHGTFVAGVIASSRECLGFAPDADLYIFKVFTNS-- 232
            . |.....:: .|::..|.:.        .|||..||.:|:                 |..|.
  Rat   164 AGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAA-----------------VANNGVC 211

  Fly   233 --QVSYTSWFLDAFNYAIYRKINILNLSIGGPDFMDSPFVEKV----LELSANNVIMISAAGN-- 289
              .|:|                   |..|||...:|....:.|    |.|:.|::.:.||:..
  Rat   212 GVGVAY-------------------NARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPE 257

  Fly   290 ------DGP--------LYGTLNNPGDQSDVV----GVGGIQFDD-------------KIAKFSS 323
                  |||        ..|.....|....:.    |.||.:.|.             .|:..:.
  Rat   258 DDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQ 322

  Fly   324 RGMTTWELPLGYGRMGLDIVTYGS------QVEGSDVRKGCRRL-SGTSVSSPVVAGAAALLISG 381
            .|...|........:.   .||.|      |:..:|:|:.|... :|||.|:|:.||..||.:.
  Rat   323 FGNVPWYSEACSSTLA---TTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLE- 383

  Fly   382 AFQKIDYINPASLKQVLIEGAEKLPHYNMFE---QGAGKLNLLKSMQLLLSYKPKITLIPAYLDF 443
            |.:.:.:.:    .|.|:....|..|.|..:   .|.|:       ::..||...:....|.:..
  Rat   384 ANKNLTWRD----MQHLVVQTSKPAHLNANDWATNGVGR-------KVSHSYGYGLLDAGAMVAL 437

  Fly   444 TQNY---------MWPYSSQPLYYGSSVAIANVTILNGISVTSHIVGIPKWIPDFENQGQFLQVS 499
            .||:         :....::|...|..:.:..       :||: .:|.|..|...|:....|.:|
  Rat   438 AQNWTTVAPQRKCIIEILAEPKDIGKRLEVRK-------TVTA-CLGEPNHISRLEHVQARLTLS 494

  Fly   500 AQ---------VSPIVWPWTGWMSVFIAVKKEGENFEGV--------------CKGSITLVLESF 541
            ..         :||:     |..|..:|.:....:.:|.              ..|...|.:|:.
  Rat   495 YNRRGDLAIHLISPM-----GTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENT 554

  Fly   542 KQTTNETHVTEVDFPLTIKVTPK-----PPRNKR----------ILWDQYHSL-------RYPPR 584
            .:..|...:|:  |.|.:..|..     ||.:..          ::.::..||       |.||.
  Rat   555 SEANNYGTLTK--FTLVLYGTASEGLSAPPESSGCKTLTSSQACVVCEEGFSLHQKSCVQRCPPG 617

  Fly   585 YIPR 588
            :.|:
  Rat   618 FTPQ 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S1P	NP_649337.2	Peptidases_S8_SKI-1_like	154..407	CDD:173805	69/310 (22%)
		DUF4350	610..754	CDD:464118
Furin	NP_062204.2	S8_pro-domain	33..107	CDD:465126	20/94 (21%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	113..402	CDD:173789	73/345 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..186		5/25 (20%)
		P_proprotein	484..570	CDD:460225	16/92 (17%)
		Cell attachment site. /evidence=ECO:0000255|PROSITE-ProRule:PRU00293	498..500		0/1 (0%)
		FU 1. /evidence=ECO:0000255	577..620		7/42 (17%)
		FU	581..618	CDD:214589	7/36 (19%)
		FU 2. /evidence=ECO:0000255	638..681
		FU	638..>675	CDD:214589
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	673..698
		Cell surface signal. /evidence=ECO:0000250|UniProtKB:P09958	758..761
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	766..793
		Trans Golgi network signal. /evidence=ECO:0000250|UniProtKB:P09958	772..778