DRSC/TRiP Functional Genomics Resources

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Protein Alignment S1P and PCSK5

DIOPT Version :10

Sequence 1:NP_649337.2 Gene:S1P / 40399 FlyBaseID:FBgn0037105 Length:1012 Species:Drosophila melanogaster
Sequence 2:NP_001358972.1 Gene:PCSK5 / 5125 HGNCID:8747 Length:1887 Species:Homo sapiens


Alignment Length:402 Identity:87/402 - (21%)
Similarity:139/402 - (34%) Gaps:131/402 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 IIERLQTH------PSV----KAVVPQRSVRRILNYD------AYSN------LTYIH----RHP 127
            :|....||      |.|    :.||.:|:.|   :||      .|.|      :.|:|    .||
Human    84 VISSRGTHSFISMEPKVEWIQQQVVKKRTKR---DYDFSRAQSTYFNDPKWPSMWYMHCSDNTHP 145

  Fly   128 QGVLRNRNPNNDRHRQLC-SVLHANILWKLGITGKGVKVAIFDTGLTKNHPHFRNVKERTNW--- 188
                             | |.::....||.|.|||.:.|.|.|.|:.:.||....     |:   
Human   146 -----------------CQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQ-----NYDAL 188

  Fly   189 ----TNEKSLD--------DRVSHGTFVAGVI---ASSREC-LGFAPDADLYIFKVFTNSQVSYT 237
                .|...||        :...|||..||.:   |::..| :|.|.:|.:...::.........
Human   189 ASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMV 253

  Fly   238 SWFLDAFNYAIYRKINILNLSIG---------GPDFMDSPFVEKVLELSANNV---------IMI 284
            .....:||   .:.::|.:.|.|         ||    :|...:..|   |.|         :.:
Human   254 EAKSVSFN---PQHVHIYSASWGPDDDGKTVDGP----APLTRQAFE---NGVRMGRRGLGSVFV 308

  Fly   285 SAAGNDGPLYGTLNNPGDQSDVVGVGGIQFDDKIAKFSSRGMTTWELPLGYGRMGLDIVTYGS-- 347
            .|:||.|       ...|.....|.....:...|:..:..|...|.|......:.   .||.|  
Human   309 WASGNGG-------RSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLA---TTYSSGE 363

  Fly   348 ----QVEGSDVRKGCR-RLSGTSVSSPVVAGAAALLISGAFQKIDYINPASLKQVLIEGAEKLPH 407
                ::..:|:|:.|. ..:|||.|:|:.||..||    |.:...::....::.|::..:.    
Human   364 SYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIAL----ALEANPFLTWRDVQHVIVRTSR---- 420

  Fly   408 YNMFEQGAGKLN 419
                   ||.||
Human   421 -------AGHLN 425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
S1PNP_649337.2 Peptidases_S8_SKI-1_like 154..407 CDD:173805 64/296 (22%)
DUF4350 610..754 CDD:464118
PCSK5NP_001358972.1 S8_pro-domain 38..114 CDD:465126 8/29 (28%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 126..420 CDD:173789 71/339 (21%)
P_proprotein 505..595 CDD:460225
Cell attachment site. /evidence=ECO:0000255 519..521
FU 1 630..680
GF_recep_IV 635..744 CDD:464344
VSP 724..1100 CDD:146106
FU 1084..1129 CDD:238021
FU 1126..1162 CDD:214589
FU 1209..1256 CDD:238021
VSP 1291..>1576 CDD:146106
GF_recep_IV 1596..1713 CDD:464344
FU 1695..1736 CDD:214589
AC 1. /evidence=ECO:0000250 1834..1853
AC 2. /evidence=ECO:0000250 1865..1887
Blue background indicates that the domain is not in the aligned region.

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