Protein Alignment S1P and mbtps1

DIOPT Version :10

• Sequence 1: NP_649337.2
• Gene: S1P / 40399
• FlyBaseID: FBgn0037105
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: NP_954683.2
• Gene: mbtps1 / 326710
• ZFINID: ZDB-GENE-030131-4909
• Length: 1074
• Species: Danio rerio
• Alignment Length: 1070
• Identity: 483/1070 - (45%)
• Similarity: 649/1070 - (60%)
• Gaps: 137/1070 - (12%)

  Fly    10 ISAICS-----LDAFKTAVVPNEFIVHFHSKYFAPVRESYIAAKLLGSNVTNWRIVPRLNLAWQY 69
            :|..||     || |.|.||.:|:||.|:..:.|..|..:|::.|...:...||||.|.|.|..|
Zfish    44 LSPNCSQLTLKLD-FSTQVVKHEYIVAFNGYFTAKARSDFISSALRDVDAVKWRIVRRDNPASDY 107

  Fly    70 PSDFDILRVCDGYESSSEFIIERLQTHPSVKAVVPQRSVRRILNY-------------------- 114
            ||||:::.:.....:|    :..||.||.:|.|.|||.|.|.|.:
Zfish   108 PSDFEVVEIKQDTRNS----LLTLQDHPYIKRVTPQRMVLRSLKFTDSGTDGASPCNDTRWVQKW 168

  Fly   115 DAYSNLTYIHR----------HPQGVLRNRNPNNDRHRQLCSVLHANILWKLGITGKGVKVAIFD 169
            .::.:...:.|          |..|...:|.......|.:..:|.|::||::|.||.|||||:||
Zfish   169 QSWQSSRPLRRTSLSLSSGFWHATGRHSSRRLLRAIPRHVAQILQADVLWQMGHTGSGVKVAVFD 233

  Fly   170 TGLTKNHPHFRNVKERTNWTNEKSLDDRVSHGTFVAGVIASSRECLGFAPDADLYIFKVFTNSQV 234
            |||::.||||:||||||||||||:|||.:.|||||||||||.|||.|||||::|:||:||||:||
Zfish   234 TGLSEKHPHFKNVKERTNWTNEKTLDDGLGHGTFVAGVIASMRECQGFAPDSELHIFRVFTNNQV 298

  Fly   235 SYTSWFLDAFNYAIYRKINILNLSIGGPDFMDSPFVEKVLELSANNVIMISAAGNDGPLYGTLNN 299
            ||||||||||||||.:||::||||||||||||.|||:||.||:||.|||:||.||||||||||||
Zfish   299 SYTSWFLDAFNYAILKKIDVLNLSIGGPDFMDHPFVDKVWELTANKVIMVSAIGNDGPLYGTLNN 363

  Fly   300 PGDQSDVVGVGGIQFDDKIAKFSSRGMTTWELPLGYGRMGLDIVTYGSQVEGSDVRKGCRRLSGT 364
            |.||.||:|||||.|:|.||:||||||||||||.||||:..|||||||.|.||.:::|||.||||
Zfish   364 PADQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRVKPDIVTYGSGVRGSGLKEGCRSLSGT 428

  Fly   365 SVSSPVVAGAAALLISGAFQKIDYINPASLKQVLIEGAEKLPHYNMFEQGAGKLNLLKSMQLLLS 429
            ||:|||||||..||.|....: :.:||||:||.||..|.:||..||||||.|||:||::.|:|.|
Zfish   429 SVASPVVAGAVTLLASTVLNR-ELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNS 492

  Fly   430 YKPKITLIPAYLDFTQ-NYMWPYSSQPLYYGSSVAIANVTILNGISVTSHIVGIPKWIPDFENQG 493
            |||:.:|.|:|:|.|: .|||||.|||:|||....|.|||||||:.||..||..|.|.|.....|
Zfish   493 YKPQASLSPSYIDLTECPYMWPYCSQPIYYGGMPTIVNVTILNGMGVTGRIVEKPIWQPYLPQNG 557

  Fly   494 QFLQVSAQVSPIVWPWTGWMSVFIAVKKEGENFEGVCKGSITLVLESFKQTTNETHV-----TEV 553
            .::.|:...||::|||.|:::|.|:|.|:..::||:.:|.:.:.:.|  ...|::.:     :.|
Zfish   558 DYVDVAVSYSPVLWPWAGYLAVSISVAKKAASWEGIAQGHVMVTVAS--PAENDSAIGGEMTSTV 620

  Fly   554 DFPLTIKVTPKPPRNKRILWDQYHSLRYPPRYIPRDDLKVKLDPLDWRADHIHTNFRDMYTHLRN 618
            ..|:.:|:.|.|||:|||||||||:|||||.|.|||:|::|.|||||..|||||||||||.|||:
Zfish   621 KLPVKVKIVPTPPRSKRILWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTNFRDMYQHLRS 685

  Fly   619 VGYYIDVLREPFTCFNASDYGALLIVDPERGFGDEEINALQENVYKRGLNVVVFGDWYNTTVMKK 683
            :||:::||..|.|||:||.||.||:||.|..:..|||..|:.:: ..||:::||.|||||:||:|
Zfish   686 MGYFVEVLGAPITCFDASQYGTLLMVDSEEEYFPEEITKLRRDI-DNGLSLIVFSDWYNTSVMRK 749

  Fly   684 IKFFDENTRQWWTPDTGGANIPALNDLLKPFGIAFGDFVGEGHFKLGDHSMYYASGATIVKFPMN 748
            :||:||||||||.|||||||:||||||:..:|:||.|.:.||.|.|.||.||||||.:|.:||.:
Zfish   750 VKFYDENTRQWWMPDTGGANVPALNDLISVWGMAFSDGLYEGDFTLADHDMYYASGCSIARFPED 814

  Fly   749 PGDIIVGTKLNDQGLSIINSKTPSKVAKLDVPIFGMFQTKANSIQSNEEIVVNAESNLAEAIPTD 813
              .|::...|.||||.::..:|   ....:||:.|::||                       |:|
Zfish   815 --GIVIAQTLKDQGLEVLKQET---AVVENVPVLGLYQT-----------------------PSD 851

  Fly   814 YSTFKNRVLLLRTKQRSISFAKSNNHETKNEGRIAVYGDSNCLDSTHLEKACYWLLITFLDF-AI 877
                                         ..||||:||||||:|.:|.:|.|:|||...|.: :.
Zfish   852 -----------------------------GGGRIALYGDSNCIDDSHRQKDCFWLLDALLQYTSY 887

  Fly   878 NSHKSSLLQNLNRITEFHKLERAPLPLRIS-------QSIIKSRSQDNN------CEQFKWLAPT 929
            :....||..:.||:......:| |||.|:.       ..::::...|..      |....|..|.
Zfish   888 SMTPPSLTHSKNRLVPPTGTDR-PLPQRLEGNHLYRYSKVLEAHLGDPKPRPLPACPHLSWAKPQ 951

  Fly   930 KQNNA--------EERKSSIIDVTILENEEHEINLIKNLLGEEIAKLGQNNDYLTGMQSADSLMT 986
            ..|..        ::..|..:|..:|.|.......::.|...|..........:.|..:.:...|
Zfish   952 PLNETAPSNLWKHQKLLSVDMDKVVLPNVRAYRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQT 1016

  Fly   987 PIIFLIILSLIVIMLFVLFL-------KRR 1009
            ..:|..:.:::|:..||:.|       |||
Zfish  1017 IPMFAFLGAMVVLSFFVVQLTKAKSKPKRR 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S1P	NP_649337.2	Peptidases_S8_SKI-1_like	154..407	CDD:173805	184/252 (73%)
		DUF4350	610..754	CDD:464118	83/143 (58%)
mbtps1	NP_954683.2	Peptidases_S8_SKI-1_like	218..470	CDD:173805	184/252 (73%)