Protein Alignment S1P and Pcsk1

DIOPT Version :10

• Sequence 1: NP_649337.2
• Gene: S1P / 40399
• FlyBaseID: FBgn0037105
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: NP_058787.1
• Gene: Pcsk1 / 25204
• RGDID: 3272
• Length: 752
• Species: Rattus norvegicus
• Alignment Length: 967
• Identity: 176/967 - (18%)
• Similarity: 289/967 - (29%)
• Gaps: 393/967 - (40%)

  Fly     4 FTFLFIISAICSLDAFKTAVVPNEFIVHFHSKYFAPVRESYIAAKL-------LGSNVTNW---- 57
            ||...:..|:.|:.|.:..|  ||:....|.   .|...|.||.:|       :||...::
  Rat    13 FTLFCVWCALNSVKAKRQFV--NEWAAEIHG---GPEAASAIAEELGYDLLGQIGSLENHYLFKH 72

  Fly    58 RIVPR------LNLAWQYPSDFDILRVCDGYESSSEFIIERLQTHPSVKAVVPQRSVRRILNYDA 116
            :..||      |::..:...|..::.....||....            |..||:.|...:.|...
  Rat    73 KNHPRRSRRSALHITKRLSDDDRVIWAEQQYEKERR------------KRSVPRDSALNLFNDPM 125

  Fly   117 YSNLTYIHRHPQGVLRNRNPNNDRHRQLCSV----LHANILWKLGITGKGVKVAIFDTGLTKNHP 177
            ::...|:               ...|...|:    ||...:|:.|||||||.:.:.|.||..||.
  Rat   126 WNQQWYL---------------QDTRMTASLPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHT 175

  Fly   178 HFRNVKERTNWTNEKSLD---------------DRVSHGTFVAGVI---ASSREC-LGFAPDA-- 221
            ..     ..|:..|.|.|               :...|||..||.|   |::.:| :|.|.::
  Rat   176 DI-----YANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKV 235

  Fly   222 ------DLYIFKVFTNSQVSYTSWFLDAFNYAIYRKINILNLSIGGPD----FMDSP--FVEKVL 274
                  |..:......|.:.:....:|.::            :..||:    .::.|  ..:|..
  Rat   236 GGIRMLDGIVTDAIEASSIGFNPGHVDIYS------------ASWGPNDDGKTVEGPGRLAQKAF 288

  Fly   275 EL------SANNVIMISAAGNDGPLYGTLNNPGDQSDVVGVGGIQFDDKIAKFSSRGMTTWELPL 333
            |.      .....|.:.|:||.|       ..||..|..|.....:...|:..|.:|::.|....
  Rat   289 EYGVKQGRQGKGSIFVWASGNGG-------RQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEK 346

  Fly   334 GYGRMGLDIVTYGS------QVEGSDVRKGCRRL-SGTSVSSPVVAGAAALLISGAFQKIDYINP 391
            ....:.   .:|.|      ::..:|:...|... :|||.|:|:.||..||.:..        ||
  Rat   347 CSSTLA---TSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEA--------NP 400

  Fly   392 ASLKQVLIEGAEKLPHYNMFEQGAGKLNLL-KSMQLLLSYKPKITLIPAYLDFTQNYMWPYSSQP 455
                                       ||. :.||.|:                   :|.....|
  Rat   401 ---------------------------NLTWRDMQHLV-------------------VWTSEYDP 419

  Fly   456 LYYGSSVAIANVTILNGISVTSHIVGIPKWIPDFENQGQFLQVSAQ----------VSPIVWPWT 510
            |        ||                   .|.::..|..|.|:::          :..:..|.|
  Rat   420 L--------AN-------------------NPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRT 457

  Fly   511 GWMSVFIAVKKE----GENFEG---VCKGSI-----TLVLESFKQTTNETHVTEVDFPLTIKVTP 563
             |.:|  ..|||    ..|||.   ...|.:     |...|..:...|.  :..|.|..||:
  Rat   458 -WRNV--PEKKECIIKDNNFEPRALKANGEVIVEIPTRACEGQENAINS--LEHVQFEATIE--- 514

  Fly   564 KPPRNKRILWDQYHSLRYPPRYIPRDDLKVKLDPL---------------------DWRADHIHT 607
                                 |..|.||.|.|...                     :|....:||
  Rat   515 ---------------------YSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHT 558

  Fly   608 -----------NFRDMYTHLRNVGYYI-------------DVLREP--FTCFNASDYGALLIVDP 646
                       ...||...::|.|..:             :.:::|  :|.:|.       :.:.
  Rat   559 WGENPVGTWTLKVTDMSGRMQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSYNT-------VQND 616

  Fly   647 ERGFGDEEINALQENVYKRGLNVVVFGDWYNTTVMKKIKFFDENTRQWWTPDTGGANIPALNDLL 711
            .||. ::.:|.::|...:..||       .|..|.|.........|:  .....||...|:..||
  Rat   617 RRGV-EKMVNVVEEKPTQNSLN-------GNLLVPKNSSSSSVEDRR--DEQVQGAPSKAMLRLL 671

  Fly   712 KPFGIAFGDFVGEGHFKLGDHSMYYASGATIVKFPMNPGDIIVGTKLNDQGLSIINSKTPSK--- 773
            :                                                   |..:..||||
  Rat   672 Q---------------------------------------------------SAFSKNTPSKQSS 685

  Fly   774 ---VAKLDVPIFGMFQ-----TKANSIQSNEEIVVNAESNLAEAIPTDYST--FKNR 820
               .|||.||..|:::     .|.:.::.:|      :|..::.:...|:|  :|:|
  Rat   686 KIPSAKLSVPYEGLYEALEKLNKPSQLEDSE------DSLYSDYVDVFYNTKPYKHR 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S1P	NP_649337.2	Peptidases_S8_SKI-1_like	154..407	CDD:173805	63/298 (21%)
		DUF4350	610..754	CDD:464118	22/158 (14%)
Pcsk1	NP_058787.1	S8_pro-domain	34..110	CDD:465126	15/90 (17%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	121..415	CDD:173789	75/389 (19%)
		P_proprotein	504..591	CDD:460225	17/110 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	631..662		6/39 (15%)
		Proho_convert	712..750	CDD:463483	6/31 (19%)