Protein Alignment S1P and Pcsk2

DIOPT Version :10

• Sequence 1: NP_649337.2
• Gene: S1P / 40399
• FlyBaseID: FBgn0037105
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: NP_036878.1
• Gene: Pcsk2 / 25121
• RGDID: 3273
• Length: 637
• Species: Rattus norvegicus
• Alignment Length: 583
• Identity: 123/583 - (21%)
• Similarity: 199/583 - (34%)
• Gaps: 182/583 - (31%)

  Fly    92 RLQTHPSVKAVVPQ----------RSVRRI---LNYDAYSNLTYIHRHPQGVLRNRNPNNDRHRQ 143
            :|:..|.:|..:.|          |.:..|   :|...::...|:....|.   :..|..|
  Rat    87 QLERDPRIKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLFNTGQA---DGTPGLD---- 144

  Fly   144 LCSVLHANILWKLGITGKGVKVAIFDTGLTKNHPHFRNVKERTNWTNEKSLDDRV---------- 198
                |:....|:||.|||||.:.|.|.|:...||..     ..|:.::.|.|...
  Rat   145 ----LNVAEAWELGYTGKGVTIGIMDDGIDYLHPDL-----AYNYNSDASYDFSSNDPYPYPRYT 200

  Fly   199 -----SHGTFVAGVI---ASSREC-LGFAPDADL---------YIFKVFTNSQVSYTSWFLDAFN 245
                 ||||..||.:   ||:..| :|.|.::.:         ::..:...|.:|:....:|
  Rat   201 DDWFNSHGTRCAGEVSAAASNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLID--- 262

  Fly   246 YAIYRKINILNLSIGGPD---FMDSPFVEKVLELSANNV---------IMISAAGNDGPLYGTLN 298
                    |.:.|.|..|   .:|.| .|..|:..|:.|         |.:.|:| ||..|...|
  Rat   263 --------IYSASWGPTDNGKTVDGP-RELTLQAMADGVNKGRGGKGSIYVWASG-DGGSYDDCN 317

  Fly   299 NPGDQSDV--VGVGGIQFDDKIAKFSSRGMTTWELPLGYGRMGLDIVTYGSQVEGSDVRKGCR-R 360
            ..|..|.:  :.:.....|.:.|.:.....:|.......||..    ...:.|..:|:...|. |
  Rat   318 CDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKR----NPEAGVATTDLYGNCTLR 378

  Fly   361 LSGTSVSSPVVAGAAALLISG----AFQKIDYINPASLKQVLIEGAEKLPHYNMFE---QGAGKL 418
            .||||.::|..||..||.:..    .::.:.::.      ||.....:| |..:.:   .|.|
  Rat   379 HSGTSAAAPEAAGVFALALEANVDLTWRDMQHLT------VLTSKRNQL-HDEVHQWRRNGVG-- 434

  Fly   419 NLLKSMQLLLSYKPKITLIPAYLDFTQNYMWPYSSQPLYYGSSVAIANVTILNGISVTSHIVGIP 483
                                  |:|  |:::.|.  .|..|:.|.:|.
  Rat   435 ----------------------LEF--NHLFGYG--VLDAGAMVKMAK----------------- 456

  Fly   484 KW--IPD-FENQGQFLQVSAQVSPIVWPWTGWMSVFIAVKKEGENFEGVCKGSITLV--LESFKQ 543
            .|  :|: |...|..:|...::.|     ||.:.:.:..        ..|:|....|  ||..:.
  Rat   457 DWKTVPERFHCVGGSVQNPEKIPP-----TGKLVLTLQT--------NACEGKENFVRYLEHVQA 508

  Fly   544 --TTNETHVTEVDFPLTIKVTPKPPRNKRILWDQYHSLRYPPRYIPRDDLKVKLDPLDWRADH 604
              |.|.|...:::..:|     .|...|.||      |...||   .||.||..|...:...|
  Rat   509 VITVNATRRGDLNINMT-----SPMGTKSIL------LSRRPR---DDDSKVGFDKWPFMTTH 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S1P	NP_649337.2	Peptidases_S8_SKI-1_like	154..407	CDD:173805	70/299 (23%)
		DUF4350	610..754	CDD:464118
Pcsk2	NP_036878.1	S8_pro-domain	32..108	CDD:465126	4/20 (20%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	121..417	CDD:173789	75/334 (22%)
		P_proprotein	503..590	CDD:460225	19/69 (28%)