Protein Alignment S1P and Tpp2

DIOPT Version :10

• Sequence 1: NP_649337.2
• Gene: S1P / 40399
• FlyBaseID: FBgn0037105
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: NP_033444.1
• Gene: Tpp2 / 22019
• MGIID: 102724
• Length: 1262
• Species: Mus musculus
• Alignment Length: 636
• Identity: 142/636 - (22%)
• Similarity: 242/636 - (38%)
• Gaps: 165/636 - (25%)

  Fly    35 KYFAPVRESY-IAAKLLGSNVTN------WRIVPRLNL--AWQYPSDFDILRVCDGYESSSEFII 90
            ||...::..| ...|.|...:..      |..:.|:.|  |.:...:|||..  :|...:::.|.
Mouse   109 KYHIGIKNGYDFYPKALKERIQKERKEKIWDPIHRVALAEACRKQEEFDIAN--NGSSQANKLIK 171

  Fly    91 ERLQTHPSVKAVVPQRSVRRILNYD-AYSNLTYIHRHPQGVLRNRNPNNDRHRQLCSVLHANILW 154
            |.||:           .|..:.::: .||              :..|..|     |.|.|....|
Mouse   172 EELQS-----------QVELLNSFEKKYS--------------DPGPVYD-----CLVWHDGETW 206

  Fly   155 KLGI----TGKGVKVAIFDTGLTKNHPHFRNVKERTNWTN---EKSLDDRV-------------- 198
            :..:    .|...|.|:           .||.||...:::   .:.|:..|
Mouse   207 RACVDSNENGDLSKCAV-----------LRNYKEAQEYSSFGTAEMLNYSVNIYDDGNLLSIVTS 260

  Fly   199 --SHGTFVAGVIA----SSRECLGFAPDADLYIFKVFTN--SQVSYTSWFLDAFNYAIYRKINIL 255
              :|||.||.:.|    ...|..|.||.|.:...|:...  |.:...:..:.|....|..|.:::
Mouse   261 GGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMIEVINHKCDLV 325

  Fly   256 NLSIG-GPDFMDSPFVEKVLELSA--NNVIMISAAGNDGPLYGTLNNP-GDQSDVVGVGG-IQFD 315
            |.|.| ...:.:|..:.:|:..:.  :|.|.:|:|||:||...|:..| |..|.|:|||. :..|
Mouse   326 NYSYGEATHWPNSGRICEVINEAVWKHNTIYVSSAGNNGPCLSTVGCPGGTTSSVIGVGAYVSPD 390

  Fly   316 DKIAKFSSR-----GMTTWEL--PLGYGRMGLDIVTYGSQVEG--SDVRKGCRRLSGTSVSSPVV 371
            ..:|::|.|     ...||..  |...|.:|:.|...|..:..  :...:|.:.::|||:|||..
Mouse   391 MMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPNA 455

  Fly   372 AGAAALLISG-AFQKIDYINPASLKQVLIEGAEKLPHYNMFEQGAGKLNLLKSMQLLLSYKPKIT 435
            .|..||::|| ....:|| ...|:::.|...|.|..:..:|.||.|.:.:.|:...|:    :.|
Mouse   456 CGGIALVLSGLKANNVDY-TVHSVRRALENTAIKADNIEVFAQGHGIIQVDKAYDYLI----QNT 515

  Fly   436 LIPAYLDFTQNYMWPYSSQPLYYGSSVAIANVTILNGISVTSHIVGIPKWIPDFENQGQFLQVSA 500
            .....|.||   :...:::.:|....|.:|        :.:.|.|||....|  ||.....::|.
Mouse   516 SFANRLGFT---VTVGNNRGIYLRDPVQVA--------APSDHGVGIEPVFP--ENTENSEKISF 567

  Fly   501 QVSPIVWPWTGWMS-------------VFIAVK----KEGENFEGVC-------------KGSIT 535
            |:...:...:.|:.             :.|.|.    :||.::..||             :..||
Mouse   568 QLHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAGPLFRVPIT 632

  Fly   536 LVLESFKQTTNETH----VTEVDFPLTIKVTPKPPRNKRILWDQYHSLRYP 582
            .|:.:  :....:|    .|:|.|        ||.:.:|      |.:..|
Mouse   633 AVIAA--KVNESSHYDLAFTDVHF--------KPGQIRR------HFVEVP 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S1P	NP_649337.2	Peptidases_S8_SKI-1_like	154..407	CDD:173805	76/296 (26%)
		DUF4350	610..754	CDD:464118
Tpp2	NP_033444.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	14..489	CDD:173796	100/423 (24%)
		TPPII	777..963	CDD:463636
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1010..1030