Protein Alignment S1P and Furin

DIOPT Version :10

• Sequence 1: NP_649337.2
• Gene: S1P / 40399
• FlyBaseID: FBgn0037105
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: XP_011249120.1
• Gene: Furin / 18550
• MGIID: 97513
• Length: 803
• Species: Mus musculus
• Alignment Length: 725
• Identity: 145/725 - (20%)
• Similarity: 236/725 - (32%)
• Gaps: 244/725 - (33%)

  Fly     7 LFIISA-----ICSLDAFKTAVVPNEFIVHFHSKYFAPVRESYIAAK--------LLGSNVTNW- 57
            |::::|     :.:.||....:..|.:.||...   .|.....:|.|        :.|.....|
Mouse     8 LWVVAAAGAVVLLAADAQGQKIFTNTWAVHIPG---GPAVADRVAQKHGFHNLGQIFGDYYHFWH 69

  Fly    58 RIVPRLNLAWQYPSDFDILRVCDGYESSSEFIIERLQTHPSVKAVVPQRSVRRILNYDAYSNLTY 122
            |.|.:.:|:...|..                  .|||..|.||.:..|.:.|| ...|.|...|
Mouse    70 RAVTKRSLSPHRPRH------------------SRLQREPQVKWLEQQVAKRR-AKRDVYQEPT- 114

  Fly   123 IHRHPQGVLRNRNPNNDRHRQLCSV----LHANILWKLGITGKGVKVAIFDTGLTKNHPHFR-NV 182
                        :|...:...|..|    |:....|..|.||.|:.|:|.|.|:.||||... |.
Mouse   115 ------------DPKFPQQWYLSGVTQRDLNVKEAWAQGFTGHGIVVSILDDGIEKNHPDLAGNY 167

  Fly   183 KERTNW-TNEKSLDDRV--------SHGTFVAGVIASSRECLGFAPDADLYIFKVFTNS----QV 234
            ....:: .|::..|.:.        .|||..||.:|:                 |..|.    .|
Mouse   168 DPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAA-----------------VANNGVCGVGV 215

  Fly   235 SYTSWFLDAFNYAIYRKINILNLSIGGPDF----------MDSPFVEKV----LELSANNVIMIS 285
            :|                   |..||.|.|          :|....:.|    |.|:.|::.:.|
Mouse   216 AY-------------------NARIGAPLFPPPLRPGVRMLDGEVTDAVEARSLGLNPNHIHIYS 261

  Fly   286 AAGN--------DGP--------LYGTLNNPGDQSDVV----GVGGIQFDD-------------K 317
            |:..        |||        ..|.....|....:.    |.||.:.|.             .
Mouse   262 ASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLS 326

  Fly   318 IAKFSSRGMTTWELPLGYGRMGLDIVTYGS------QVEGSDVRKGCRRL-SGTSVSSPVVAGAA 375
            |:..:..|...|........:.   .||.|      |:..:|:|:.|... :|||.|:|:.||..
Mouse   327 ISSATQFGNVPWYSEACSSTLA---TTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGII 388

  Fly   376 ALLISGAFQKIDYINPASLKQVLIEGAEKLPHYNMFE---QGAGKLNLLKSMQLLLSYKPKITLI 437
            ||.:. |.:.:.:.:    .|.|:....|..|.|..:   .|.|:       ::..||...:...
Mouse   389 ALTLE-ANKNLTWRD----MQHLVVQTSKPAHLNADDWATNGVGR-------KVSHSYGYGLLDA 441

  Fly   438 PAYLDFTQNY--MWPYSS-------QPLYYGSSVAIANVTILNGISVTSHIVGIPKWIPDFENQG 493
            .|.:...||:  :.|...       :|...|..:.:..       :||: .:|.|..|...|:..
Mouse   442 GAMVALAQNWTTVAPQRKCIVEILVEPKDIGKRLEVRK-------AVTA-CLGEPNHITRLEHVQ 498

  Fly   494 QFLQVSAQ---------VSPIVWPWTGWMSVFIAVKKEGENFEGV--------------CKGSIT 535
            ..|.:|..         :||:     |..|..:|.:....:.:|.              ..|...
Mouse   499 ARLTLSYNRRGDLAIHLISPM-----GTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPAGEWV 558

  Fly   536 LVLESFKQTTNETHVTEVDFPLTIKVT-PK----PPRNKR----------ILWDQYHSLRY---- 581
            |.:|:..:..|...:|:  |.|.:..| |:    ||.:..          ::.::.:||..
Mouse   559 LEIENTSEANNYGTLTK--FTLVLYGTAPEGLSTPPESSGCKTLTSSQACVVCEEGYSLHQKSCV 621

  Fly   582 ---PPRYIPR 588
               ||.:||:
Mouse   622 QHCPPGFIPQ 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S1P	NP_649337.2	Peptidases_S8_SKI-1_like	154..407	CDD:173805	70/320 (22%)
		DUF4350	610..754	CDD:464118
Furin	XP_011249120.1	S8_pro-domain	33..107	CDD:465126	20/95 (21%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	113..412	CDD:173789	74/355 (21%)
		P_proprotein	494..580	CDD:460225	16/92 (17%)
		FU	591..629	CDD:214589	6/37 (16%)
		FU	648..>685	CDD:214589