Protein Alignment S1P and Pcsk2

DIOPT Version :10

• Sequence 1: NP_649337.2
• Gene: S1P / 40399
• FlyBaseID: FBgn0037105
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: NP_032818.1
• Gene: Pcsk2 / 18549
• MGIID: 97512
• Length: 637
• Species: Mus musculus
• Alignment Length: 688
• Identity: 142/688 - (20%)
• Similarity: 222/688 - (32%)
• Gaps: 233/688 - (33%)

  Fly     6 FLFIISAICSLDAFKTAVVPNEFIVHFHSKYFAPVRESYIAAKLLGSNVTNWRIV---------- 60
            |||.:....|.:   ..|..|.|:|..|.......|:  :||: .|..|......
Mouse    14 FLFCVMVFASAE---RPVFTNHFLVELHKDGEEEARQ--VAAE-HGFGVRKLPFAEGLYHFYHNG 72

  Fly    61 -------------------PRLNLAWQYPSDFDILRVCDGYESSSEFIIERLQTHPSVKAVVPQR 106
                               ||:.:|.| ...||  |...||...:|..|.
Mouse    73 LAKAKRRRSLHHKRQLERDPRIKMALQ-QEGFD--RKKRGYRDINEIDIN--------------- 119

  Fly   107 SVRRILNYDAYSNLTYIHRHPQGVLRNRNPNNDRHRQLCSVLHANILWKLGITGKGVKVAIFDTG 171
                 :|...::...|:....|.   :..|..|        |:....|:||.|||||.:.|.|.|
Mouse   120 -----MNDPLFTKQWYLFNTGQA---DGTPGLD--------LNVAEAWELGYTGKGVTIGIMDDG 168

  Fly   172 LTKNHPH------------------FRNVKERTNWTNEKSLDDRVSHGTFVAGVI---ASSREC- 214
            :...||.                  :...:...:|.|        ||||..||.:   ||:..|
Mouse   169 IDYLHPDLAYNYNADASYDFSSNDPYPYPRYTDDWFN--------SHGTRCAGEVSAAASNNICG 225

  Fly   215 LGFAPDADL---------YIFKVFTNSQVSYTSWFLDAFNYAIYRKINILNLSIGGPD---FMDS 267
            :|.|.::.:         ::..:...|.:|:....:|           |.:.|.|..|   .:|.
Mouse   226 VGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLID-----------IYSASWGPTDNGKTVDG 279

  Fly   268 PFVEKVLELSANNV---------IMISAAGNDGPLYGTLNNPGDQSDV--VGVGGIQFDDKIAKF 321
            | .|..|:..|:.|         |.:.|:| ||..|...|..|..|.:  :.:.....|.:.|.:
Mouse   280 P-RELTLQAMADGVNKGRGGKGSIYVWASG-DGGSYDDCNCDGYASSMWTISINSAINDGRTALY 342

  Fly   322 SSRGMTTWELPLGYGRMGLDIVTYGSQVEGSDVRKGCR-RLSGTSVSSPVVAGAAALLISG---- 381
            .....:|.......||..    ...:.|..:|:...|. |.||||.::|..||..||.:..
Mouse   343 DESCSSTLASTFSNGRKR----NPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLDL 403

  Fly   382 AFQKIDYINPASLKQVLIEGAEKLPHYNMFE---QGAGKLNLLKSMQLLLSYKPKITLIPAYLDF 443
            .::.:.::.      ||.....:| |..:.:   .|.|                        |:|
Mouse   404 TWRDMQHLT------VLTSKRNQL-HDEVHQWRRNGVG------------------------LEF 437

  Fly   444 TQNYMWPYSSQPLYYGSSVAIANVTILNGISVTSHIVGIPKW--IPD-FENQGQFLQVSAQVSPI 505
              |:::.|.  .|..|:.|.:|.                 .|  :|: |...|..:|...::.|
Mouse   438 --NHLFGYG--VLDAGAMVKMAK-----------------DWKTVPERFHCVGGSVQNPEKIPP- 480

  Fly   506 VWPWTGWMSVFIAVKKEGENFEGVCKGSITLV--LESFKQ--TTNETHVTEVDFPLTIKVTPKPP 566
                ||  .:.:.:|      ...|:|....|  ||..:.  |.|.|...:::..:|     .|.
Mouse   481 ----TG--KLVLTLK------TNACEGKENFVRYLEHVQAVITVNATRRGDLNINMT-----SPM 528

  Fly   567 RNKRILWDQYHSLRYPPRYIPRDDLKVKLDPLDWRADH 604
            ..|.||      |...||   .||.||..|...:...|
Mouse   529 GTKSIL------LSRRPR---DDDSKVGFDKWPFMTTH 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S1P	NP_649337.2	Peptidases_S8_SKI-1_like	154..407	CDD:173805	69/302 (23%)
		DUF4350	610..754	CDD:464118
Pcsk2	NP_032818.1	S8_pro-domain	32..108	CDD:465126	15/81 (19%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	121..417	CDD:173789	74/337 (22%)
		P_proprotein	503..590	CDD:460225	19/69 (28%)