Protein Alignment S1P and tpp-2

DIOPT Version :10

• Sequence 1: NP_649337.2
• Gene: S1P / 40399
• FlyBaseID: FBgn0037105
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: NP_495221.1
• Gene: tpp-2 / 174018
• WormBaseID: WBGene00017686
• Length: 1374
• Species: Caenorhabditis elegans
• Alignment Length: 1145
• Identity: 225/1145 - (19%)
• Similarity: 381/1145 - (33%)
• Gaps: 395/1145 - (34%)

  Fly   149 HANILWKL-------GITGKGVKVAIF-DTGLTKNHPHFRNVKERTNWTNEKSLDDRV------- 198
            |...:|::       |..|.|..:..| :||   ::.:..| |:...:|...|.|..:
 Worm   251 HDGEMWRVCIDTSFRGRLGLGNVLGTFRETG---DYAYLTN-KDSVVYTVRVSPDGNLTEIVVPS 311

  Fly   199 -SHGTFVAGVIAS----SRECLGFAPDADLYIFKVFTN--SQVSYTSWFLDAFNYAIYRKINILN 256
             :||:.|||:.|:    :.:..|.||.|.:....:..:  ..:........|||......::|:|
 Worm   312 GAHGSHVAGIAAANYPDNPQKNGLAPGAKILSLNIGDHRLGAMETGQAMTRAFNMCAELNVDIIN 376

  Fly   257 LSIGGPDFMDSPFVEKVLE-----LSANNVIMISAAGNDGPLYGTLNNP-GDQSDVVGVG----- 310
            :|.|....:  |.|.:|:|     ::...||.:.:|||.||...|:..| |..:.|:|:|
 Worm   377 MSFGEGTHL--PDVGRVIEEARRLINRRGVIYVCSAGNQGPALSTVGAPGGTTTGVIGIGAYLTS 439

  Fly   311 -------GI--QFDDKIAKFSSRGMTTWELPLGYGRMGLDIVTYGSQVEGSDVRKGCRR----LS 362
                   |:  ..:..|..:||||      |...|::|:.:|...:...|  |.:.||:    ::
 Worm   440 ESADTLYGVYKPVESSIYPWSSRG------PCQDGKLGVSLVAPAAAFAG--VPQYCRQSMQMMN 496

  Fly   363 GTSVSSPVVAGAAALLISGAFQKIDYINPASLKQVLIEGAEKLPHYNMFEQGAGKLNLL----KS 423
            |||:|||..||..|.::||..|......|.:::..|...|..|||...|.||.|.:.:.    |.
 Worm   497 GTSMSSPNAAGNVACMLSGLKQNNLKWTPYTVRMALENTAYMLPHIESFSQGQGMIKIATAYEKL 561

  Fly   424 MQLLLS--YKPKITLIP------------AYL---------DFT-------QNYM---------- 448
            .::|::  :.|::|...            .|:         :||       ||::
 Worm   562 SEILVNKVFPPRLTHFEINVSNHCKKSKGVYVREPNWNGPQEFTIGVEPIFQNHLSDNNLPAISF 626

  Fly   449 -----------WPYSSQPLY----------------------YGSSVAIAN------------VT 468
                       |....|.::                      |...|.|..            ||
 Worm   627 EKQIILQSTAPWVSHPQTMFVVAQERTMVVTVDASKAPKGANYTEIVGIDTADPSLGPIFRIPVT 691

  Fly   469 ILNGISV-----TSHIVG-----------IPKWIPDFE------NQGQFLQVSAQVSPIVWPWTG 511
            ::|...|     ||.:||           :|.|....:      |:.:..:.:..
 Worm   692 VINPEKVAVDQYTSRLVGKSGVTERRFVEVPSWATSAKITLRSTNKDEMDRFTLH---------- 746

  Fly   512 WMSVFIAVKK-----EGENFEG----------VCKGSITL---VLESFKQTTNETHVTEVDFPLT 558
              :|:|...|     |.:..:|          ..:|..||   |:.::.:..|.   .:||..:.
 Worm   747 --TVYIEDDKCSRNTETQKIQGPIGNEWSKSITVQGGKTLEACVVRAWSRGKNP---VDVDMTID 806

  Fly   559 IKVTPKPPRNKRILWDQYHSLRY---PPRYI---PRDDLK---VKLDPLDWRADHIHTNFRDMY- 613
            .....||.....|.......:|:   |.:.|   |...||   |.|.|...:.:.:..  |||:
 Worm   807 FFGVKKPTSISLIHGATNTPIRFQAAPTKSIDVSPSISLKSLVVSLKPQSAKVEPLGP--RDMFL 869

  Fly   614 ----------------------THLRNVGYYIDVLREPFTCFNASDYGA-LLIVDPERGFGDEEI 655
                                  ..|:..|....:...|..|.....:|| ...|.....:.|...
 Worm   870 TSGLQINRLLLTYQLKVQKPSEVQLQLAGLTPYLYESPVDCVLFQIFGANKSFVGASSSYPDRWT 934

  Fly   656 NALQENVYKRGLNVVVFGDWYNTTVMKKIKFFDENTRQWWTPDTGGANIPALNDLLKPFGIAFGD 720
            ..|::            ||:   |:..:|::.|:...|      |...:|.|
 Worm   935 QKLEK------------GDY---TIQAQIRYPDDQVLQ------GMKELPLL------------- 965

  Fly   721 FVGEGHFKLGDHSMY----YASGATIVKFPMNPGD-IIVGTKLNDQGLSIINSKTPSKVAKLDVP 780
                .|.|||:....    .||.||:.|.....|. ::...::....::|.:.|.|..:    ||
 Worm   966 ----VHVKLGNKISVDLAASASDATLGKECKFAGKALLPNQEMTVYAMNIADDKLPKTI----VP 1022

  Fly   781 IFGMFQTKANSIQSNEEIVVNAESNLAEAI--PTDYSTFKNRVLLLRTKQRSISFAKSNNHETKN 843
            ..|.|.....|...:.::   ::.:.:|.|  .::|||...:.|.:.|.::.    .:.|.|..:
 Worm  1023 TSGSFLAGTFSALKDSDL---SDVDKSEVIYFLSEYSTRPTKGLSMVTTKKD----TNQNQEMTD 1080

  Fly   844 EGR-IAVYGDSNCLDSTHLEKACYWLLITFLDFAINSHKSSLLQNLNRITEFHK----------- 896
            ..| :.|.......|    |||..    .|.:..:..:...|....||:.:..:
 Worm  1081 AIRDLEVSWVQKLTD----EKAAK----EFFEACLQKYPDHLPLLQNRVKQLMQAKLVDQTPENV 1137

  Fly   897 ---LERAPLPLRISQ-------SIIKSRSQDNNCEQFKWLAPTKQ------------NNAEERKS 939
               :|.....|:|::       |.:|....|:.....||||.|..            :..||||.
 Worm  1138 QKIIELCGQILQITKPNETLQFSSVKQEHDDDLLTVDKWLALTGGSEDQRKDVVKLISQFEERKK 1202

  Fly   940 SII-DVTILENEEHEINLIKN-------------------------------------------- 959
            ||| .:..|.:.|.:|.:.|:
 Worm  1203 SIILALQALSSLEQDIEVRKSKFDVPASLRFGGITPLIFGGKQGEVINKKSEGYEALKSKSEQID 1267

  Fly   960 -LLGEEIAKLGQNNDYLTGMQ---------SADSLMTPII 989
             .:.||:.||..|   .||.|         |||...|.:|
 Worm  1268 ATVSEELKKLDSN---WTGNQFYVKLLVWLSADDTKTALI 1304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S1P	NP_649337.2	Peptidases_S8_SKI-1_like	154..407	CDD:173805	76/298 (26%)
		DUF4350	610..754	CDD:464118	31/172 (18%)
tpp-2	NP_495221.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	64..539	CDD:173796	76/301 (25%)
		TPPII	832..1018	CDD:463636	41/225 (18%)