Protein Alignment S1P and S1P

DIOPT Version :10

• Sequence 1: NP_649337.2
• Gene: S1P / 40399
• FlyBaseID: FBgn0037105
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: XP_061517038.1
• Gene: S1P / 1280482
• VectorBaseID: AGAMI1_008082
• Length: 1401
• Species: Anopheles gambiae
• Alignment Length: 1146
• Identity: 532/1146 - (46%)
• Similarity: 699/1146 - (60%)
• Gaps: 201/1146 - (17%)

  Fly    19 FKTAVVPNEFIVHFHSKYFAPVRESYIAAKLLGSNVTNWRIVPRLNLAWQYPSDFDILRVCDGYE 83
            |.|.:|.||:||.|:..|....|||:|.:.|.||.|..|||:.|.|.|..:|||||:|.:    |
Mosquito   139 FSTKIVQNEYIVQFNGYYKPKERESFIQSALNGSKVQKWRILLRNNPAQDFPSDFDVLTL----E 199

  Fly    84 SSSEFI---IERLQTHPSVKAVVPQRSVRRILNY------------------------------- 114
            .:.||.   :..|:||||:|::.|||.|.|.|.|
Mosquito   200 EAIEFADDGLALLRTHPSIKSISPQRMVHRALKYVPLRQSDAHQADAEEEQEEEEEELPEQPEPE 264

  Fly   115 ----DAYSN--LTYIHRHPQGVLRN-------------RNPNNDRH----------RQLCSVLHA 150
                ||.:|  :.:|.:.......|             ::||  ||          ||:.::|.|
Mosquito   265 LELDDAETNDFIEFIQKRRLTTEANSFAQPPAPPAPPPQSPN--RHTNRRLLRAIPRQITALLKA 327

  Fly   151 NILWKLGITGKGVKVAIFDTGLTKNHPHFRNVKERTNWTNEKSLDDRVSHGTFVAGVIASSRECL 215
            ::||.:||||:|||||:|||||.|:||||:.:||||||||||:|||.|||||||||:||||:||.
Mosquito   328 DVLWSMGITGQGVKVAVFDTGLAKSHPHFKRIKERTNWTNEKTLDDGVSHGTFVAGIIASSKECF 392

  Fly   216 GFAPDADLYIFKVFTNSQVSYTSWFLDAFNYAIYRKINILNLSIGGPDFMDSPFVEKVLELSANN 280
            ||||||:|:||:||||:||||||||||||||||.:|||:||||||||||:|.|||:||||||||.
Mosquito   393 GFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKKINVLNLSIGGPDFLDQPFVDKVLELSANR 457

  Fly   281 VIMISAAGNDGPLYGTLNNPGDQSDVVGVGGIQFDDKIAKFSSRGMTTWELPLGYGRMGLDIVTY 345
            |||:||.||||||||||||||||.||:||||:.:.|.|||||||||||||||.||||:..|||||
Mosquito   458 VIMVSAIGNDGPLYGTLNNPGDQMDVIGVGGMDYADNIAKFSSRGMTTWELPYGYGRLKPDIVTY 522

  Fly   346 GSQVEGSDVRKGCRRLSGTSVSSPVVAGAAALLISGAFQK--IDYINPASLKQVLIEGAEKLPHY 408
            ||||:||::..||:.||||||:||:||||..|:.||...:  :| :||||:||.||||||:|...
Mosquito   523 GSQVKGSNLNGGCKSLSGTSVASPMVAGAVTLIASGVLDRPGVD-LNPASMKQALIEGAERLADN 586

  Fly   409 NMFEQGAGKLNLLKSMQLLLSYKPKITLIPAYLDFTQNYMWPYSSQPLYYGSSVAIANVTILNGI 473
            ||||||.||||:|:||:.|.:|:|::||.|||||||::|||||::|.|||.:...|||||||||:
Mosquito   587 NMFEQGHGKLNILRSMKALAAYRPRVTLSPAYLDFTEDYMWPYTTQSLYYSAMPVIANVTILNGM 651

  Fly   474 SVTSHIVGIPKWIPDFENQGQFLQVSAQVSPIVWPWTGWMSVFIAVKKEGENFEGVCKGSITLVL 538
            .|...::..|.|.|.....|:.|.||...|..:|||:|||:|.|.|.:.|..|||:.:|.|||.:
Mosquito   652 GVFGRVINRPTWHPYSNEHGELLNVSISYSEQLWPWSGWMAVHIGVNEAGRGFEGIAQGHITLTV 716

  Fly   539 ESFKQTTNETHVTE--VDFPLTIKVTPKPPRNKRILWDQYHSLRYPPRYIPRDDLKVKLDPLDWR 601
            :|..|..||.....  |.|.:.:::.|:|||.|||||||||||||||.|:|||:||:|.||||||
Mosquito   717 QSPPQGENEREPRNGTVSFAIKVRIIPQPPRQKRILWDQYHSLRYPPGYLPRDNLKIKSDPLDWR 781

  Fly   602 ADHIHTNFRDMYTHLRNVGYYIDVLREPFTCFNASDYGALLIVDPERGFGDEEINALQENVYKRG 666
            |||:||||:||||||||.|||::||..|:||||||.||.||:||||..|...|:..|:|:|.:|.
Mosquito   782 ADHVHTNFKDMYTHLRNAGYYVEVLGAPYTCFNASHYGTLLVVDPEEEFFPAEVAKLREDVLERQ 846

  Fly   667 LNVVVFGDWYNTTVMKKIKFFDENTRQWWTPDTGGANIPALNDLLKPFGIAFGDFVGEGHFKLGD 731
            |:|:||.|||||:||::|||:||||||||.|||||||:|||||||:.||||.||.|.:|:|.:.|
Mosquito   847 LSVIVFADWYNTSVMRRIKFYDENTRQWWMPDTGGANVPALNDLLRGFGIALGDRVADGYFDMRD 911

  Fly   732 HSMYYASGATIVKFPMNPGDIIVGTKLNDQGLSIINSKTPSKVAKLDVPIFGMFQT--------- 787
            |.|||||||.||:||:..|.|:|...|.|:||:|.....|....:....|.||.||
Mosquito   912 HRMYYASGANIVRFPVGEGTILVERDLLDEGLAITQPDEPRSKVRTRTAILGMLQTDRRVYARLQ 976

  Fly   788 ----------------------KANSIQSNEEIVVNAESNLA-------------EAIPTDYSTF 817
                                  :.:..:.:.:.::|....|:             |.:|.|...|
Mosquito   977 PATPNPEGAPPLAPPDELPEEWEEDGGKIDRDAIINKRILLSAAVGGAGGDVEEDEDVPNDGGEF 1041

  Fly   818 K-----NRV------------------LLLRTKQRSISFAKSNNHETKNE---------GRIAVY 850
            .     |||                  .|||.:.:::   |.:|..|...         ||||:|
Mosquito  1042 NRDDAMNRVDAGEEPLPEDDRDGDDLGQLLRERTKAV---KQHNSTTARTGGRPELLAGGRIALY 1103

  Fly   851 GDSNCLDSTHLEKACYWLLITFLDFAINSHKSSLLQNLNRITEFHKL-ERAPLPLRI-------- 906
            |||||||||||||.|:|||.:.|::.:.:|.:|||::||...:..:: |...||.|:
Mosquito  1104 GDSNCLDSTHLEKPCFWLLDSLLEYTMTAHVTSLLRDLNVSRQVEQIEENVKLPQRMPNNNLHLY 1168

  Fly   907 SQSIIKSRSQDNN-----CEQFKWLAPTK------------------QNNAEERKSSIIDVTILE 948
            |:.::...:....     |::.:|..|..                  |...::::..::.|...:
Mosquito  1169 SKVLVAHTTTGEKRPIPVCQRLEWEYPVTLNMSSLSFGTGPNDHLLVQEQQQQQQQQLLVVQQRQ 1233

  Fly   949 NEEHEINLIKNLLGEEI----------------AKLGQNND 973
            .::.....|..|:|.|:                |.||.|::
Mosquito  1234 LKQGPPQPIMPLVGNELVYSSRGRRLESQKGGNAALGANDE 1274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S1P	NP_649337.2	Peptidases_S8_SKI-1_like	154..407	CDD:173805	191/254 (75%)
		DUF4350	610..754	CDD:464118	94/143 (66%)
S1P	XP_061517038.1	None