Protein Alignment S1P and pcsk1

DIOPT Version :10

• Sequence 1: NP_649337.2
• Gene: S1P / 40399
• FlyBaseID: FBgn0037105
• Length: 1012
• Species: Drosophila melanogaster
• Sequence 2: NP_001131134.1
• Gene: pcsk1 / 100005716
• ZFINID: ZDB-GENE-071009-1
• Length: 755
• Species: Danio rerio
• Alignment Length: 546
• Identity: 115/546 - (21%)
• Similarity: 198/546 - (36%)
• Gaps: 167/546 - (30%)

  Fly   148 LHANILWKLGITGKGVKVAIFDTGLTKNH----PHFRNVKE------------RTNWTNEKSLDD 196
            ||...:||.|||||||.:.:.|.||..||    |::.....            |.:.|||.
Zfish   149 LHVIPVWKKGITGKGVVITVLDDGLEWNHTDIYPNYDPAASYDFNDNDPDPFPRYDSTNEN---- 209

  Fly   197 RVSHGTFVAGVI---ASSREC-LGFAPDA--------DLYIFKVFTNSQVSYTSWFLDAFNYAIY 249
              .|||..||.|   |.:.:| :|.|.::        |..:......|.:.|....:|.::
Zfish   210 --KHGTRCAGEIAMQADNNKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGYNPDHVDIYS---- 268

  Fly   250 RKINILNLSIGGPD----FMDSP--FVEKVLEL------SANNVIMISAAGNDGPLYGTLNNPGD 302
                    :..||:    .::.|  ..:|..|.      .....|.:.|:||.|       ..||
Zfish   269 --------ASWGPNDDGKTVEGPGRLAQKAFEYGIQKGRGGKGSIFVWASGNGG-------RQGD 318

  Fly   303 QSDVVGVGGIQFDDKIAKFSSRGMTTWELPLGYG-RMGLDIVT-YGS------QVEGSDVRKGCR 359
            ..|..|.....:...|:..|.:|::.|     |. :....:.| |.|      ::..:|:...|.
Zfish   319 NCDCDGYTDSLYTISISSASQQGLSPW-----YAEKCSSTLATAYSSGDYTDQRITSADLHNECT 378

  Fly   360 RL-SGTSVSSPVVAGAAALLISGAFQKIDYINP----ASLKQVLIEGAEKLPHYN---MFEQGAG 416
            .. :|||.|:|:.||..||.:..        ||    ..|:.:::..:|..|..|   ....|||
Zfish   379 ETHTGTSASAPLAAGIFALALEQ--------NPDLTWRDLQHLVVWTSEFDPLANNPGWKRNGAG 435

  Fly   417 KLNLLKSMQL---LLSYKPKITLIPAYLDFTQNYMW--------------PYSSQPLYYGSSVAI 464
               |:.:.:.   ||:.|       |.:|.....:|              .:..:||.....::|
Zfish   436 ---LMVNSRFGFGLLNAK-------ALVDLADPKVWKHVPEKKQCIVRDETFQPRPLKAAGEISI 490

  Fly   465 -----ANVTILNGISVTSHI---VGIPKWIPDFENQGQFLQVSAQVSPIVWPWTGWMSV------ 515
                 |.....|.:....|:   |.|     ::..:|. |.::. .||     :|..:|
Zfish   491 EIPTKACAGQANSVMSLEHVQVEVSI-----EYTRRGD-LHITL-TSP-----SGTTTVLLAERE 543

  Fly   516 ------------FIAVKKEGENFEGVCKGSITLVLESFKQTTNETHVTEVDFPLTIKVTPKPPRN 568
                        |::|...|||..|..   |..:.::..:..||..:  :.:.|.:..|.:.|.:
Zfish   544 RDTSSNGFRNWAFMSVHTWGENPTGTW---ILKITDTSGRMENEGQI--ISWKLILHGTSEKPEH 603

  Fly   569 --KRILWDQYHSLRYPPRYI-PRDDL 591
              |..::..|::::...|.: |.:|:
Zfish   604 MKKARVYTPYNAVQNDRRGVEPMEDM 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S1P	NP_649337.2	Peptidases_S8_SKI-1_like	154..407	CDD:173805	70/305 (23%)
		DUF4350	610..754	CDD:464118
pcsk1	NP_001131134.1	S8_pro-domain	32..108	CDD:465126
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	124..418	CDD:173789	71/306 (23%)
		P_proprotein	507..594	CDD:460225	19/103 (18%)
		Proho_convert	714..752	CDD:463483