DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfAP-2 and TFAP2C

DIOPT Version :9

Sequence 1:	NP_001262178.1	Gene:	TfAP-2 / 40398	FlyBaseID:	FBgn0261953	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_003213.1	Gene:	TFAP2C / 7022	HGNCID:	11744	Length:	450	Species:	Homo sapiens

Alignment Length:	449	Identity:	202/449 - (44%)
Similarity:	266/449 - (59%)	Gaps:	45/449 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 HSGGHTGRSGPATGHSGHSSTH--GSAATMHHQSLQSDFQPPYFPPPFHHSTQSPPQQQISGYLQ 102
            |.|...|  .|...|...:..|  ..|..:.|..:.....|||||||:         ||:: |.|
Human    19 HDGSSNG--NPRVPHLSSAGQHLYSPAPPLSHTGVAEYQPPPYFPPPY---------QQLA-YSQ 71

  Fly   103 NHGALEYLGTDPYGQPLSSLHH-APLHHYNQLAGLRSTQDQLGIHRTH-REAELQGHVTQLSHGF 165
            :.....:|| :.|...::.||. ||.....|....|.:|:..|:...| |.|.|..|::.|..|
Human    72 SADPYSHLG-EAYAAAINPLHQPAPTGSQQQAWPGRQSQEGAGLPSHHGRPAGLLPHLSGLEAG- 134

  Fly   166 PYTDRRSDY-GSAISAGAAHGTRLGHEHESLALHQALQNAVDDVQAPALDDNVAFMSDLPLIK-- 227
            ..:.||..| .|.:....||........|:|.||. :.:.:|:||  .:||....:.|..:|:
Human   135 AVSARRDAYRRSDLLLPHAHALDAAGLAENLGLHD-MPHQMDEVQ--NVDDQHLLLHDQTVIRKG 196

  Fly   228 ---------SMKSGKEAGNIGS-GSPSEVFCAVPGRLSLLSSTSKYKVTIAEVQRRLSPPECLNA 282
                     ::...||.  :|: .:|:||||:|||||||||||||||||:|||||||||||||||
Human   197 PISMTKNPLNLPCQKEL--VGAVMNPTEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNA 259

  Fly   283 SLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEATHLAKDFHFVCETE 347
            |||||||||||||||||.|||||:||||||||||||||:||||||||||||.|||:||.:|||.|
Human   260 SLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVTLLTSLVEGEAVHLARDFAYVCEAE 324

  Fly   348 FPARQLAEYIVR-HQTEPQDSYRRKELILHSQQITKELMQILSQDRTTHFGTRSQHLLEPSMQRH 411
            ||::.:|||:.| |.....:...||.::|.:||:.||..::||||||.|..:|...:||.::|..
Human   325 FPSKPVAEYLTRPHLGGRNEMAARKNMLLAAQQLCKEFTELLSQDRTPHGTSRLAPVLETNIQNC 389

  Fly   412 LTHFSLITHGFGSPAIMAVLHAFQTFLNESLNYLEKLYPSNGGGMVSSSLDKSKIDNEK 470
            |:|||||||||||.||.|.:.|.|.::.|:|..::|.|.:.|        |:|..|:.|
Human   390 LSHFSLITHGFGSQAICAAVSALQNYIKEALIVIDKSYMNPG--------DQSPADSNK 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfAP-2	NP_001262178.1	TF_AP-2	247..441	CDD:397406	133/194 (69%)
TFAP2C	NP_003213.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..63		13/45 (29%)
		PPxY motif	59..64		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..126		12/35 (34%)
		TF_AP-2	224..419	CDD:367440	133/194 (69%)
		H-S-H (helix-span-helix), dimerization	293..424		70/130 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..450		5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160187
Domainoid	1	1.000	277	1.000	Domainoid score	I1732
eggNOG	1	0.900	-	-		E1_KOG3811
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2522
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287275at33208
OrthoFinder	1	1.000	-	-		FOG0000991
OrthoInspector	1	1.000	-	-		otm40888
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10812
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10438
SonicParanoid	1	1.000	-	-		X400
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.930