DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TfAP-2 and TFAP2B

DIOPT Version :9

Sequence 1:	NP_001262178.1	Gene:	TfAP-2 / 40398	FlyBaseID:	FBgn0261953	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	XP_016866722.1	Gene:	TFAP2B / 7021	HGNCID:	11743	Length:	515	Species:	Homo sapiens

Alignment Length:	479	Identity:	212/479 - (44%)
Similarity:	272/479 - (56%)	Gaps:	65/479 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GHGSLGLSSGSAAYTTHSGGHTGRSGPATGHSGHSSTHGSAATMHHQSL-------QSDFQPPYF 81
            |...|.:...|.....|:.....|......||...|..||.:...:.|.       .||||||||
Human    61 GDQVLRIREVSLQMLVHTYSSMDRHDGVPSHSSRLSQLGSVSQGPYSSAPPLSHTPSSDFQPPYF 125

  Fly    82 PPPF----HHSTQSPPQQQISGYLQNHGALEYLGTDPYGQPLSSLHHAPLHHYNQLAGLRSTQDQ 142
            |||:    :|.:|.|         .:|      ..|||.  |:.||....|.:.|    |..| :
Human   126 PPPYQPLPYHQSQDP---------YSH------VNDPYS--LNPLHQPQQHPWGQ----RQRQ-E 168

  Fly   143 LGIHRTHREAELQGHVTQLSHGFPYTDRRSDYGS-----AISAGAAHGTRLGHEHESLALHQALQ 202
            :|........:.:..:.|||.    .|.|.||.|     .:...|.||...| ..:||:||....
Human   169 VGSEAGSLLPQPRAALPQLSG----LDPRRDYHSVRRPDVLLHSAHHGLDAG-MGDSLSLHGLGH 228

  Fly   203 NAVDDVQA---------PALDDNVAFMSDLP--LIKSMKSGKEAGNIG--SGSPSEVFCAVPGRL 254
            ..::|||:         ..||.:|.....:|  .:.|:...|: |.:|  |.:..||||:|||||
Human   229 PGMEDVQSVEDANNSGMNLLDQSVIKKVPVPPKSVTSLMMNKD-GFLGGMSVNTGEVFCSVPGRL 292

  Fly   255 SLLSSTSKYKVTIAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKA 319
            ||||||||||||:.|||||||||||||||||||||||||||||||.|||:|||||||||||||||
Human   293 SLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLRERLEKIGLNLPAGRRKA 357

  Fly   320 ANVTLLTSLVEGEATHLAKDFHFVCETEFPARQLAEYIVRHQTEPQDSYRRKELILHSQQITKEL 384
            ||||||||||||||.|||:||.::|||||||:.::||:.|..|:|.|.:.||.::|.::|:.||.
Human   358 ANVTLLTSLVEGEAVHLARDFGYICETEFPAKAVSEYLNRQHTDPSDLHSRKNMLLATKQLCKEF 422

  Fly   385 MQILSQDRTTHFGTRSQHLLEPSMQRHLTHFSLITHGFGSPAIMAVLHAFQTFLNESLNYLEKLY 449
            ..:|:||||....:|...:|||.:|..||||||||||||:|||.|.|.|.|.:|.|:|..::|::
Human   423 TDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLITHGFGAPAICAALTALQNYLTEALKGMDKMF 487

  Fly   450 PSN--------GGGMVSSSLDKSK 465
            .:|        |.|..|.:.||.:
Human   488 LNNTTTNRHTSGEGPGSKTGDKEE 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfAP-2	NP_001262178.1	TF_AP-2	247..441	CDD:397406	136/193 (70%)
TFAP2B	XP_016866722.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160189
Domainoid	1	1.000	277	1.000	Domainoid score	I1732
eggNOG	1	0.900	-	-		E1_KOG3811
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2522
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287275at33208
OrthoFinder	1	1.000	-	-		FOG0000991
OrthoInspector	1	1.000	-	-		otm40888
orthoMCL	1	0.900	-	-		OOG6_105211
Panther	1	1.100	-	-	O	PTHR10812
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X400
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.800