DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TfAP-2 and tfap2d

DIOPT Version :9

Sequence 1:	NP_001262178.1	Gene:	TfAP-2 / 40398	FlyBaseID:	FBgn0261953	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001020717.1	Gene:	tfap2d / 566838	ZFINID:	ZDB-GENE-050913-99	Length:	450	Species:	Danio rerio

Alignment Length:	464	Identity:	197/464 - (42%)
Similarity:	260/464 - (56%)	Gaps:	85/464 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 HSGGHTGR---SGPATGHSGHSSTHGSAATMHHQSLQSDFQPPYFP-----PPFHHSTQSPPQQQ 96
            |.|.::.|   .|.....:..|..:.|::.:.:.:..::|..||||     .|.||      |..
Zfish    16 HDGSNSYRLMQLGCLESVANSSVAYSSSSPLTYPATGTEFASPYFPTNHQYTPLHH------QSF 74

  Fly    97 ISGYLQNHGALEYLGTDPYGQPLSSLHHA-----PLHH---------YNQLAGLRSTQD----QL 143
            ...:..:|.|:     :|....|:||||:     .|||         :|..|...|..|    :|
Zfish    75 HYEFQHSHPAV-----NPDAYSLNSLHHSQQYYQQLHHGEPADFINLHNARALKSSCLDEQRREL 134

  Fly   144 GIHRTHREAELQGHVTQLSHGFPYTDRRSDYGSAISAGAAHGTRLGHEHESLALHQALQNAVDDV 208
            |....:|..:|    :.:|||       |.||.........|..||                  :
Zfish   135 GCLDAYRRHDL----SIMSHG-------SQYGMHPEQRLLPGAGLG------------------L 170

  Fly   209 QAPALDD---NVAFMSDLPLIKSMKSGKEAGNIGSG-----SPSEVFCAVPGRLSLLSSTSKYKV 265
            ..|..||   :|.....|.|      ..:.|.|..|     :|:::||:||||||||||||||||
Zfish   171 PPPGADDLQGSVDAQCGLVL------NGQGGVIRRGGTCVVNPTDLFCSVPGRLSLLSSTSKYKV 229

  Fly   266 TIAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVE 330
            |||||:||||||||||||||||:||:||||||||.|||||:::||||||||||||||||||||||
Zfish   230 TIAEVKRRLSPPECLNASLLGGILRKAKSKNGGRCLREKLDRLGLNLPAGRRKAANVTLLTSLVE 294

  Fly   331 GEATHLAKDFHFVCETEFPARQLAEYIVRHQTEPQDSYRRKELILHSQQITKELMQILSQDRTTH 395
            |||.|||:||.:.||||||.:.:.|::.|..|||::...||:::|.::||.||...:|||||:..
Zfish   295 GEALHLARDFGYTCETEFPTKAVGEHLARQHTEPKEQNARKKMVLATKQICKEFQDLLSQDRSPL 359

  Fly   396 FGTRSQHLLEPSMQRHLTHFSLITHGFGSPAIMAVLHAFQTFLNESLNYLEKLYPSNGGG----- 455
            ..:|...:|:..:|||||||||||||||:|||.|.|..|||.|:|.||||||...:...|
Zfish   360 GSSRPTPILDLDIQRHLTHFSLITHGFGTPAICAALSTFQTILSEMLNYLEKHSANKSTGTPDTN 424

  Fly   456 MVSSSLDKS 464
            .::|:.||:
Zfish   425 QINSNSDKT 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfAP-2	NP_001262178.1	TF_AP-2	247..441	CDD:397406	133/193 (69%)
tfap2d	NP_001020717.1	TF_AP-2	209..409	CDD:281315	136/199 (68%)
		H-S-H (helix-span-helix), dimerization. /evidence=ECO:0000255	280..410		76/129 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..450		4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596528
Domainoid	1	1.000	278	1.000	Domainoid score	I1679
eggNOG	1	0.900	-	-		E1_KOG3811
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2463
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287275at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26176
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10812
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X400
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.860