DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfAP-2 and Tfap2c

DIOPT Version :9

Sequence 1:	NP_001262178.1	Gene:	TfAP-2 / 40398	FlyBaseID:	FBgn0261953	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	XP_006235753.1	Gene:	Tfap2c / 362280	RGDID:	1303185	Length:	492	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	195/453 - (43%)
Similarity:	260/453 - (57%)	Gaps:	41/453 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SAAYTTHSGGHTGRSGPATGHSGHSSTH--GSAATMHHQSLQSDFQPPYFPPPFHHSTQSPPQQQ 96
            |.:...|.....|  .|...|...:..|  ..|..:.|..:.....|||||||:         ||
  Rat    55 SLSQDRHDASSNG--NPRIPHLSSAGQHLYSPAPPLSHTGVAEYQPPPYFPPPY---------QQ 108

  Fly    97 ISGYLQNHGALEYLGTDPYGQPLSSLHH-APLHHYNQLAGLRSTQDQLGIHRTH-REAELQGHVT 159
            :: |.|:.....:|| :.|...::.||. ||.....|....|.:|:...:...| |.|.|..|::
  Rat   109 LA-YSQSADHYSHLG-EAYAAAINPLHQPAPTGSQQQAWPGRQSQEGSSLASHHGRSAGLIPHIS 171

  Fly   160 QLSHGFPYTDRRSDY-GSAISAGAAHGTRLGHEHESLALHQALQNAVDDVQAPALDDNVAFMSDL 223
            .| .|...:.||..| .|.:....||........|:|.||: :.:.:::||  .:||....:.|.
  Rat   172 GL-EGSAVSSRREAYRRSDLLLPHAHALEAAGLAENLGLHE-MAHPIEEVQ--NVDDPHLLLHDQ 232

  Fly   224 PLIKSMKSGKEAGNIGSG----------SPSEVFCAVPGRLSLLSSTSKYKVTIAEVQRRLSPPE 278
            .:|:..........:|..          :||||||:|||||||||||||||||:|||||||||||
  Rat   233 TVIRKGPISMTKNPLGLPCQKDLVGAVMNPSEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPE 297

  Fly   279 CLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEATHLAKDFHFV 343
            |||||||||||||||||||||.|||||:||||||||||||||:||||||||||||.|||:||.:|
  Rat   298 CLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVTLLTSLVEGEAVHLARDFAYV 362

  Fly   344 CETEFPARQLAEYIVR-HQTEPQDSYRRKELILHSQQITKELMQILSQDRTTHFGTRSQHLLEPS 407
            ||.|||::.:|:|:.| |.....:...||.::|.:||:.||...:|.||||.:..:|...:||.:
  Rat   363 CEAEFPSKAVADYLTRPHLGGRNEMAARKSVLLAAQQVCKEFTDLLHQDRTPNGNSRPTPVLETN 427

  Fly   408 MQRHLTHFSLITHGFGSPAIMAVLHAFQTFLNESLNYLEKLYPSNGGGMVSSSLDKSKIDNEK 470
            :|..|:|||||||||||.||.|.:.|.|.::.|:|..::|.|.:.|        ::|..|:.|
  Rat   428 IQNCLSHFSLITHGFGSQAICAAVSAVQNYIKEALITIDKSYMNPG--------EQSPADSNK 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfAP-2	NP_001262178.1	TF_AP-2	247..441	CDD:397406	130/194 (67%)
Tfap2c	XP_006235753.1	TF_AP-2	264..462	CDD:281315	133/197 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354254
Domainoid	1	1.000	277	1.000	Domainoid score	I1652
eggNOG	1	0.900	-	-		E1_KOG3811
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2431
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287275at33208
OrthoFinder	1	1.000	-	-		FOG0000991
OrthoInspector	1	1.000	-	-		otm45027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10812
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X400
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.900