DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TfAP-2 and TFAP2E

DIOPT Version :9

Sequence 1:	NP_001262178.1	Gene:	TfAP-2 / 40398	FlyBaseID:	FBgn0261953	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_848643.2	Gene:	TFAP2E / 339488	HGNCID:	30774	Length:	442	Species:	Homo sapiens

Alignment Length:	466	Identity:	213/466 - (45%)
Similarity:	263/466 - (56%)	Gaps:	79/466 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 MERLSGHGSLGLSSGSAAYTTHSGGHTGRSGPATGHSGHSSTHGSAATMHHQSLQSDFQPPYFPP 83
            |||..|   ||.::|.|..::......|.:.|.        .|..|||     ..::||||||||
Human     9 MERPDG---LGAAAGGARLSSLPQAAYGPAPPL--------CHTPAAT-----AAAEFQPPYFPP 57

  Fly    84 PFHHSTQSP-PQQQISGYLQNHGALEYLGTDPYG--------QPLSSLHHAPLHHYNQLAGLRST 139
            |:   .|.| |..|..   ....|..:|..||||        ||..:...||      .|..|:.
Human    58 PY---PQPPLPYGQAP---DAAAAFPHLAGDPYGGLAPLAQPQPPQAAWAAP------RAAARAH 110

  Fly   140 QDQLGIHRTHREAELQGHVTQLSHGFPYTDRRSDYGSAIS------AGAAHG---TRLGHEHESL 195
            ::..|:        |......|.     .|.|.||.:|:.      |..|||   ..||  ...|
Human   111 EEPPGL--------LAPPARALG-----LDPRRDYATAVPRLLHGLADGAHGLADAPLG--LPGL 160

  Fly   196 ALHQALQN--AVDDVQAPALDDNV----------AFMSDLPLIKSMKSGKEAGNIGSGSPSEVFC 248
            |....|::  |:|:.....||.:|          :.:|.|.|.|....|      |..:|.||||
Human   161 AAAPGLEDLQAMDEPGMSLLDQSVIKKVPIPSKASSLSALSLAKDSLVG------GITNPGEVFC 219

  Fly   249 AVPGRLSLLSSTSKYKVTIAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLP 313
            :|||||||||||||||||:.|||||||||||||||||||||||||||||||.|||:|||||||||
Human   220 SVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRCLRERLEKIGLNLP 284

  Fly   314 AGRRKAANVTLLTSLVEGEATHLAKDFHFVCETEFPARQLAEYIVRHQTEPQDSYRRKELILHSQ 378
            ||||||||||||||||||||.|||:||.:||||||||:..|||:.|...:|.:.:.||.::|.::
Human   285 AGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAAAEYLCRQHADPGELHSRKSMLLAAK 349

  Fly   379 QITKELMQILSQDRTTHFGTRSQHLLEPSMQRHLTHFSLITHGFGSPAIMAVLHAFQTFLNESLN 443
            ||.||...:::|||:....:|...:|||.:|..||||||||||||.|||.|.|.|||.:|.|||.
Human   350 QICKEFADLMAQDRSPLGNSRPALILEPGVQSCLTHFSLITHGFGGPAICAALTAFQNYLLESLK 414

  Fly   444 YLEKLYPSNGG 454
            .|:|::.|:.|
Human   415 GLDKMFLSSVG 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfAP-2	NP_001262178.1	TF_AP-2	247..441	CDD:397406	136/193 (70%)
TFAP2E	NP_848643.2	PPxY motif. /evidence=ECO:0000255	54..59		4/4 (100%)
		TF_AP-2	216..414	CDD:281315	140/197 (71%)
		H-S-H (helix-span-helix), dimerization. /evidence=ECO:0000255	287..417		75/129 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160185
Domainoid	1	1.000	277	1.000	Domainoid score	I1732
eggNOG	1	0.900	-	-		E1_KOG3811
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2522
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287275at33208
OrthoFinder	1	1.000	-	-		FOG0000991
OrthoInspector	1	1.000	-	-		otm40888
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10812
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10438
SonicParanoid	1	1.000	-	-		X400
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.930