DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfAP-2 and Tfap2e

DIOPT Version :9

Sequence 1:	NP_001262178.1	Gene:	TfAP-2 / 40398	FlyBaseID:	FBgn0261953	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_945198.2	Gene:	Tfap2e / 332937	MGIID:	2679630	Length:	442	Species:	Mus musculus

Alignment Length:	499	Identity:	220/499 - (44%)
Similarity:	269/499 - (53%)	Gaps:	111/499 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 MERLSGHGSLGLSSG--------SAAYTTHSGGHTGRSGPATGHSGHSSTHGSAATMHHQSLQSD 75
            |||..|   ||.::|        .|||           |||.     ...|..||     |..:|
Mouse     9 MERPDG---LGAAAGGTRLSSLPQAAY-----------GPAP-----PLCHTPAA-----SATAD 49

  Fly    76 FQPPYFPPPFHHSTQSPPQQQISGYLQN---HGALEYLGTDPYG--------QPLSSLHHAP--- 126
            :.|||||||:       ||..:. |.|.   ..|..:|..||||        ||..:...||
Mouse    50 YHPPYFPPPY-------PQAPLP-YGQGPDATAAFPHLAADPYGGLAPLAQPQPPQAAWAAPRAA 106

  Fly   127 LHHYNQLAGLRSTQDQ-LGIHRTHREAELQGHVTQLSHGFPYTDRRSDYGSAIS------AGAAH 184
            ...:::..||.:...: ||:                       |.|.||.:|:.      |..||
Mouse   107 ARAHDEPPGLLAPPARALGL-----------------------DPRRDYAAAVPRLLHSLADGAH 148

  Fly   185 G---TRLGHEHESLALHQALQ--NAVDDVQAPALDDNVAFMSDLPLIKSMKSGKEAGNI------ 238
            |   ..||  ...||....|:  .|:||.....||.:|        ||.:....:||::
Mouse   149 GLADAPLG--LPGLAEPPGLEELQAIDDPGMSLLDQSV--------IKKVPIPSKAGSLSTLALS 203

  Fly   239 ------GSGSPSEVFCAVPGRLSLLSSTSKYKVTIAEVQRRLSPPECLNASLLGGVLRRAKSKNG 297
                  |..:||||||:|||||||||||||||||:.|||||||||||||||||||||||||||||
Mouse   204 KDSLVGGISNPSEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNG 268

  Fly   298 GRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEATHLAKDFHFVCETEFPARQLAEYIVRHQT 362
            ||.|||:|||||||||||||||||||||||||||||.|||:||.:||||||||:..|||:.|...
Mouse   269 GRCLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAAAEYLCRQHA 333

  Fly   363 EPQDSYRRKELILHSQQITKELMQILSQDRTTHFGTRSQHLLEPSMQRHLTHFSLITHGFGSPAI 427
            :|.:.:.||.::|.::||.||...:::|||:....:|...:|||.:|..||||||||||||.|||
Mouse   334 DPGELHSRKSMLLAAKQICKEFADLMAQDRSPLGNSRPALILEPGVQSCLTHFSLITHGFGGPAI 398

  Fly   428 MAVLHAFQTFLNESLNYLEKLYPSNGGGMVSSSLDKSKIDNEKK 471
            .|.|.|||.:|.|||..|||::.|..||....|....|....:|
Mouse   399 CAALTAFQNYLLESLKGLEKMFLSGAGGGHGESKASEKDTKHRK 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfAP-2	NP_001262178.1	TF_AP-2	247..441	CDD:397406	136/193 (70%)
Tfap2e	NP_945198.2	PPxY motif. /evidence=ECO:0000255	54..59		4/4 (100%)
		TF_AP-2	216..414	CDD:281315	140/197 (71%)
		H-S-H (helix-span-helix), dimerization. /evidence=ECO:0000255	287..417		75/129 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850562
Domainoid	1	1.000	277	1.000	Domainoid score	I1710
eggNOG	1	0.900	-	-		E1_KOG3811
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2473
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287275at33208
OrthoFinder	1	1.000	-	-		FOG0000991
OrthoInspector	1	1.000	-	-		otm42961
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10812
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10438
SonicParanoid	1	1.000	-	-		X400
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.930