DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfAP-2 and Tfap2e

DIOPT Version :9

Sequence 1:	NP_001262178.1	Gene:	TfAP-2 / 40398	FlyBaseID:	FBgn0261953	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001178693.1	Gene:	Tfap2e / 313596	RGDID:	1563297	Length:	442	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	217/479 - (45%)
Similarity:	265/479 - (55%)	Gaps:	105/479 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 MERLSG----HGSLGLSS-GSAAYTTHSGGHTGRSGPATGHSGHSSTHGSAATMHHQSLQSDFQP 78
            |||..|    .|...||| ..|||           |||.     ...|..||     |..:|:.|
  Rat     9 MERPDGLCAAAGGTRLSSLPQAAY-----------GPAP-----PLCHTPAA-----SATTDYHP 52

  Fly    79 PYFPPPFHHSTQSPPQQQISGYLQN---HGALEYLGTDPYG--------QPLSSLHHAP---LHH 129
            ||||||:       ||.|:. |.|.   ..|..:|..||||        ||..:...||   ...
  Rat    53 PYFPPPY-------PQAQLP-YGQGPDAAAAFPHLAPDPYGGLAPLAQPQPPQAAWAAPRAAARA 109

  Fly   130 YNQLAGLRSTQDQ-LGIHRTHREAELQGHVTQLSHGFPYTDRRSDYGSAIS------AGAAHG-- 185
            :::..||.:...: ||:                       |.|.||.:|:.      |..|||
  Rat   110 HDEPPGLLAPPARALGL-----------------------DPRRDYAAAVPRLLHSLADGAHGLA 151

  Fly   186 -TRLGHEHESLALHQALQ--NAVDDVQAPALDDNVAFMSDLPLIKSMKSGKEAGNI--------- 238
             ..||  ...||....|:  .|:||.....||.:|        ||.:....:||::
  Rat   152 DAPLG--LPGLAAPPGLEELQAIDDPGMSLLDQSV--------IKKVPVPSKAGSLSTLSLSKDS 206

  Fly   239 ---GSGSPSEVFCAVPGRLSLLSSTSKYKVTIAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRL 300
               |..:||||||:|||||||||||||||||:.|||||||||||||||||||||||||||||||.
  Rat   207 LVGGINNPSEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRC 271

  Fly   301 LREKLEKIGLNLPAGRRKAANVTLLTSLVEGEATHLAKDFHFVCETEFPARQLAEYIVRHQTEPQ 365
            |||:|||||||||||||||||||||||||||||.|||:||.:||||||||:..|||:.|...:|.
  Rat   272 LRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAAAEYLGRQHADPG 336

  Fly   366 DSYRRKELILHSQQITKELMQILSQDRTTHFGTRSQHLLEPSMQRHLTHFSLITHGFGSPAIMAV 430
            :.:.||.::|.::||.||...:::|||:....:|...:|||.:|..||||||||||||.|||.|.
  Rat   337 ELHSRKSMLLAAKQICKEFADLMAQDRSPLGNSRPALILEPGVQSCLTHFSLITHGFGGPAICAA 401

  Fly   431 LHAFQTFLNESLNYLEKLYPSNGG 454
            |.|||.:|.|||..|:|::.|:.|
  Rat   402 LTAFQNYLLESLKGLDKMFLSSAG 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfAP-2	NP_001262178.1	TF_AP-2	247..441	CDD:397406	136/193 (70%)
Tfap2e	NP_001178693.1	TF_AP-2	216..414	CDD:281315	140/197 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354258
Domainoid	1	1.000	277	1.000	Domainoid score	I1652
eggNOG	1	0.900	-	-		E1_KOG3811
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2431
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287275at33208
OrthoFinder	1	1.000	-	-		FOG0000991
OrthoInspector	1	1.000	-	-		otm45027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10812
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X400
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900