DRSC/TRiP Functional Genomics Resources

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Protein Alignment TfAP-2 and Tfap2b

DIOPT Version :10

Sequence 1:NP_001262178.1 Gene:TfAP-2 / 40398 FlyBaseID:FBgn0261953 Length:471 Species:Drosophila melanogaster
Sequence 2:XP_006495554.1 Gene:Tfap2b / 21419 MGIID:104672 Length:475 Species:Mus musculus


Alignment Length:442 Identity:204/442 - (46%)
Similarity:261/442 - (59%) Gaps:57/442 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 HSGGHTGRSGPATGHSGHSSTHGSAATMHHQSL-------QSDFQPPYFPPPF----HHSTQSPP 93
            |:.....|......||...|..||.:...:.|.       .|||||||||||:    :|.:|.| 
Mouse    31 HTYSSMDRHDGVPSHSSRLSQLGSVSQGPYSSAPPLSHTPSSDFQPPYFPPPYQPLPYHQSQDP- 94

  Fly    94 QQQISGYLQNHGALEYLGTDPYGQPLSSLHHAPLHHYNQLAGLRSTQDQLGIHRTHREAELQGHV 158
                    .:|      ..|||.  |:.||....|.:.|    |..| ::|........:.:..:
Mouse    95 --------YSH------VNDPYS--LNPLHQPQQHPWGQ----RQRQ-EVGSEAGSLLPQPRAAL 138

  Fly   159 TQLSHGFPYTDRRSDYGS-----AISAGAAHGTRLGHEHESLALHQALQNAVDDVQA-------- 210
            .|||.    .|.|.||.|     .:...|.||...| ..:||:||......::|||:        
Mouse   139 PQLSG----LDPRRDYHSVRRPDVLLHSAHHGLDAG-MGDSLSLHGLGHPGMEDVQSVEDANNSG 198

  Fly   211 -PALDDNVAFMSDLP--LIKSMKSGKEAGNIG--SGSPSEVFCAVPGRLSLLSSTSKYKVTIAEV 270
             ..||.:|.....:|  .:.|:...|: |.:|  |.:..||||:|||||||||||||||||:.||
Mouse   199 MNLLDQSVIKKVPVPPKSVTSLMMNKD-GFLGGMSVNTGEVFCSVPGRLSLLSSTSKYKVTVGEV 262

  Fly   271 QRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEATH 335
            |||||||||||||||||||||||||||||.|||:|||||||||||||||||||||||||||||.|
Mouse   263 QRRLSPPECLNASLLGGVLRRAKSKNGGRSLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVH 327

  Fly   336 LAKDFHFVCETEFPARQLAEYIVRHQTEPQDSYRRKELILHSQQITKELMQILSQDRTTHFGTRS 400
            ||:||.::|||||||:.::||:.|..|:|.|.:.||.::|.::|:.||...:|:||||....:|.
Mouse   328 LARDFGYICETEFPAKAVSEYLNRQHTDPSDLHSRKNMLLATKQLCKEFTDLLAQDRTPIGNSRP 392

  Fly   401 QHLLEPSMQRHLTHFSLITHGFGSPAIMAVLHAFQTFLNESLNYLEKLYPSN 452
            ..:|||.:|..||||||||||||:|||.|.|.|.|.:|.|:|..::|::.:|
Mouse   393 SPILEPGIQSCLTHFSLITHGFGAPAICAALTALQNYLTEALKGMDKMFLNN 444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TfAP-2NP_001262178.1 TF_AP-2 247..441 CDD:460877 136/193 (70%)
Tfap2bXP_006495554.1 TF_AP-2 239..433 CDD:460877 136/193 (70%)

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