DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfAP-2 and Tfap2a

DIOPT Version :9

Sequence 1:	NP_001262178.1	Gene:	TfAP-2 / 40398	FlyBaseID:	FBgn0261953	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	XP_030103084.1	Gene:	Tfap2a / 21418	MGIID:	104671	Length:	482	Species:	Mus musculus

Alignment Length:	483	Identity:	216/483 - (44%)
Similarity:	279/483 - (57%)	Gaps:	73/483 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SSGSAAYTTHSGGHTGR--SGPATG----------HSGHS--------------STHGSAATMHH 69
            ::||.:...:|.|...|  ..||.|          |.|.|              |.:.||..:.|
Mouse    28 AAGSTSQAQNSVGSRQRVPGAPARGARPPLHPEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSH 92

  Fly    70 QSLQSDFQPPYFPPPFHHSTQSPPQQQISGYLQNHGALEYLGTDPYGQPLSSLHHAPLHHYNQLA 134
             :..:||||||||||:         |.|  |.|:.....:: .|||.  |:.||..|...:....
Mouse    93 -TPNADFQPPYFPPPY---------QPI--YPQSQDPYSHV-NDPYS--LNPLHAQPQPQHPGWP 142

  Fly   135 GLRSTQDQLGIHRTHREAELQGHVTQLSHGFPYTDRRSDYGSAISAGAAHGTR-LGHEHESLALH 198
            |.|.:|:. |:..|||         .|.|.....|.|.||..  .....||.. ||.....|.:|
Mouse   143 GQRQSQES-GLLHTHR---------GLPHQLSGLDPRRDYRR--HEDLLHGPHGLGSGLGDLPIH 195

  Fly   199 QALQNAVDDVQAPALDDNVAFMSDLPLIKS-----MKSGKEA--------GNIGSG--SPSEVFC 248
             :|.:|::||  |.::|....:.|..:||.     .||...|        .|:..|  :|:||||
Mouse   196 -SLPHAIEDV--PHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFC 257

  Fly   249 AVPGRLSLLSSTSKYKVTIAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLP 313
            :|||||||||||||||||:||||||||||||||||||||||||||||||||.|||||:|||||||
Mouse   258 SVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLP 322

  Fly   314 AGRRKAANVTLLTSLVEGEATHLAKDFHFVCETEFPARQLAEYIVRHQTEPQDSYRRKELILHSQ 378
            ||||||||||||||||||||.|||:||.:||||||||:.:||::.|..::|.:...||.::|.::
Mouse   323 AGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVARKNMLLATK 387

  Fly   379 QITKELMQILSQDRTTHFGTRSQHLLEPSMQRHLTHFSLITHGFGSPAIMAVLHAFQTFLNESLN 443
            ||.||...:|:|||:....:|...:|||.:|..||||:||:|||||||:.|.:.|.|.:|.|:|.
Mouse   388 QICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALK 452

  Fly   444 YLEKLYPSNGGGMVSSSLDKSKIDNEKK 471
            .::|:|.||.....:.:..||. |.|:|
Mouse   453 AMDKMYLSNNPNSHTDNSAKSS-DKEEK 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfAP-2	NP_001262178.1	TF_AP-2	247..441	CDD:397406	133/193 (69%)
Tfap2a	XP_030103084.1	TF_AP-2	256..450	CDD:367440	133/193 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850559
Domainoid	1	1.000	277	1.000	Domainoid score	I1710
eggNOG	1	0.900	-	-		E1_KOG3811
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2421
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2473
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287275at33208
OrthoFinder	1	1.000	-	-		FOG0000991
OrthoInspector	1	1.000	-	-		otm42961
orthoMCL	1	0.900	-	-		OOG6_105211
Panther	1	1.100	-	-	O	PTHR10812
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10438
SonicParanoid	1	1.000	-	-		X400
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.830