DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TfAP-2 and tfap2a

DIOPT Version :9

Sequence 1:	NP_001262178.1	Gene:	TfAP-2 / 40398	FlyBaseID:	FBgn0261953	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	XP_005162615.1	Gene:	tfap2a / 140618	ZFINID:	ZDB-GENE-011212-6	Length:	457	Species:	Danio rerio

Alignment Length:	446	Identity:	205/446 - (45%)
Similarity:	273/446 - (61%)	Gaps:	50/446 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 HSGGHTGRSG-PATGHSGHSSTHGSAATMHHQSLQSDFQPPYFPPPFHHSTQSPPQQQISGYLQN 103
            |.|...|.:. |..|..| .|.:.||..:.| :..|||||||||||:         |.|  |.|:
Zfish    44 HDGTSNGTARLPQLGSVG-QSPYTSAPPLSH-TPNSDFQPPYFPPPY---------QPI--YPQS 95

  Fly   104 HGALEYLGTDPYGQPLSSLHHAPLHHYNQLAGLRSTQDQLGIHRTHREAELQGHVTQLSHGFPYT 168
            .....:: .|||.  ::|||......:....|.|.:|:...:|: ||             |.|:.
Zfish    96 QDPYSHV-NDPYS--INSLHAQSQPQHPGWPGQRQSQESSLLHQ-HR-------------GLPHQ 143

  Fly   169 DRRSDYGSAISAGAAHGTRLGHEHESLALHQALQNAVDDVQAPALDDNVAFMSDLPLIKS--MKS 231
            ..| :|...:...:.||...|.. :|:.:| .:.::::|||  .::|....:.|..:||.  :..
Zfish   144 LCR-EYRREVLLPSGHGIDTGLT-DSIPIH-GIPHSLEDVQ--QVEDQGIHIPDQTVIKKGPVSI 203

  Fly   232 GKEAGNI------------GSGSPSEVFCAVPGRLSLLSSTSKYKVTIAEVQRRLSPPECLNASL 284
            .|...||            |..:|:||||:|||||||||||||||||:|||||||||||||||||
Zfish   204 SKNNSNISAIPINKDGLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASL 268

  Fly   285 LGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEATHLAKDFHFVCETEFP 349
            |||||||||||||||.|||||:|||||||||||||||||||||||||||.|||:||.:|||||||
Zfish   269 LGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFP 333

  Fly   350 ARQLAEYIVRHQTEPQDSYRRKELILHSQQITKELMQILSQDRTTHFGTRSQHLLEPSMQRHLTH 414
            |:.:|||:.|..::|.:..:||.::|.::||.||...:|||||:....:|.|.:|||.:|..|||
Zfish   334 AKAIAEYMNRQHSDPNEQVQRKNMLLATKQICKEFTDLLSQDRSPLGNSRPQPILEPGIQSCLTH 398

  Fly   415 FSLITHGFGSPAIMAVLHAFQTFLNESLNYLEKLYPSNGGGMVSSSLDKSKIDNEK 470
            ||||:||||:||:.|.|.|.|.:|.|::..::|:|.:|.....|.:..|:...:||
Zfish   399 FSLISHGFGTPAVCAALTALQNYLTEAIKAMDKMYLNNNPNSHSETGSKAGDKDEK 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfAP-2	NP_001262178.1	TF_AP-2	247..441	CDD:397406	137/193 (71%)
tfap2a	XP_005162615.1	TF_AP-2	229..429	CDD:281315	140/199 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596530
Domainoid	1	1.000	278	1.000	Domainoid score	I1679
eggNOG	1	0.900	-	-		E1_KOG3811
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2421
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2463
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D287275at33208
OrthoFinder	1	1.000	-	-		FOG0000991
OrthoInspector	1	1.000	-	-		otm26176
orthoMCL	1	0.900	-	-		OOG6_105211
Panther	1	1.100	-	-	O	PTHR10812
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10438
SonicParanoid	1	1.000	-	-		X400
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.830