DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TfAP-2 and AgaP_AGAP011625

DIOPT Version :9

Sequence 1:	NP_001262178.1	Gene:	TfAP-2 / 40398	FlyBaseID:	FBgn0261953	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	XP_320880.4	Gene:	AgaP_AGAP011625 / 1281006	VectorBaseID:	AGAP011625	Length:	467	Species:	Anopheles gambiae

Alignment Length:	457	Identity:	336/457 - (73%)
Similarity:	395/457 - (86%)	Gaps:	13/457 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ERLSGHGSLGLSSGSAAYTTHSGGHTGRSGPATGHSG-HSSTHGSAATMHHQSLQSDFQPPYFPP 83
            |||:.||.:||||||.||:.|:||||||:|||:|||| |..:||...|||||:||||||||||||
Mosquito    19 ERLTSHGGIGLSSGSPAYSAHTGGHTGRNGPASGHSGSHGGSHGPGPTMHHQTLQSDFQPPYFPP 83

  Fly    84 PFHHSTQSPPQQQISGYLQNHGALEYLGTDPYGQPLSSLHHAPLHHYNQLAGLRSTQDQLGIHRT 148
            ||||:|||||||      |||| |:||.||||||||||||||||||||||||||.:|:|||:||:
Mosquito    84 PFHHTTQSPPQQ------QNHG-LDYLSTDPYGQPLSSLHHAPLHHYNQLAGLRPSQEQLGLHRS 141

  Fly   149 HREAELQGHVTQLSHGFPYTDRRSDYGSAISAGAAHGTRLG-HEHESLALHQALQNAVDDVQAPA 212
            |||:|||.|||||||||||:||||||..:|.:||. .|||| |||:.||||||||:||||.|.|.
Mosquito   142 HRESELQQHVTQLSHGFPYSDRRSDYSGSIGSGAG-ATRLGAHEHDPLALHQALQSAVDDGQNPV 205

  Fly   213 LDDNVAFMSDLPLIKSM---KSGKEAGNIGSGSPSEVFCAVPGRLSLLSSTSKYKVTIAEVQRRL 274
            :|:|..|||||||:|:.   ...|::..|..||||:|||:|||||||||||||||||:|||||||
Mosquito   206 IDENAGFMSDLPLLKNFPITDIKKDSSQINLGSPSDVFCSVPGRLSLLSSTSKYKVTVAEVQRRL 270

  Fly   275 SPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEATHLAKD 339
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||:|
Mosquito   271 SPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEAIHLARD 335

  Fly   340 FHFVCETEFPARQLAEYIVRHQTEPQDSYRRKELILHSQQITKELMQILSQDRTTHFGTRSQHLL 404
            |.:||||||||||:|||:.|..:|||:|||||||:|:::|:|||||.:|:|||:....||.||:|
Mosquito   336 FGYVCETEFPARQVAEYLSRQYSEPQESYRRKELLLNTKQVTKELMDLLNQDRSPLCNTRPQHIL 400

  Fly   405 EPSMQRHLTHFSLITHGFGSPAIMAVLHAFQTFLNESLNYLEKLYPSNGGGMVSSSLDKSKIDNE 469
            :||:||||||||||:||||||||:|.|.|.|.:||||:.:|:|:||.|||.||:|||||:|::::
Mosquito   401 DPSIQRHLTHFSLISHGFGSPAIVAALTAIQNYLNESIKHLDKMYPGNGGSMVTSSLDKNKMESD 465

  Fly   470 KK 471
            ||
Mosquito   466 KK 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TfAP-2	NP_001262178.1	TF_AP-2	247..441	CDD:397406	156/193 (81%)
AgaP_AGAP011625	XP_320880.4	TF_AP-2	241..441	CDD:281315	159/199 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	329	1.000	Domainoid score	I3139
eggNOG	1	0.900	-	-		E1_KOG3811
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2421
Inparanoid	1	1.050	686	1.000	Inparanoid score	I1927
OMA	1	1.010	-	-		QHG27045
OrthoDB	1	1.010	-	-		D287275at33208
OrthoFinder	1	1.000	-	-		FOG0000991
OrthoInspector	1	1.000	-	-		otm50067
Panther	1	1.100	-	-	LDO	PTHR10812
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X400
TreeFam	1	0.960	-	-
	13	12.940