DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EMC10 and Smc4

DIOPT Version :9

Sequence 1:	NP_730662.2	Gene:	EMC10 / 40396	FlyBaseID:	FBgn0052441	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_598547.1	Gene:	Smc4 / 70099	MGIID:	1917349	Length:	1286	Species:	Mus musculus

Alignment Length:	162	Identity:	40/162 - (24%)
Similarity:	75/162 - (46%)	Gaps:	37/162 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LANVEQPDLSTADLDLLKKLALGNE------FYRLKATVVYSNGAKAQFITSNKACR----LLQA 113
            ::.::.|:.:....||:|   :.||      ::.|:.|:|.:|..:|..:...:..|    .||.
Mouse   679 MSKIQTPENTPRLFDLVK---VKNEEIRQAFYFALRDTLVANNLDQATRVAYQRDRRWRVVTLQG 740

  Fly   114 QLNDVLWVSLEPSGYVT--GITVSQDTAPATI--ECTQEDVNKLLETQFSTDVLIRHAELA-PVP 173
            |:       :|.||.::  |..|.:....:::  |.:.|:||| :|:|     |.||::.| .:.
Mouse   741 QI-------IEQSGTMSGGGSKVMRGRMGSSVIDEISVEEVNK-MESQ-----LERHSKQAMQIQ 792

  Fly   174 DTAGFIQKVERERE-ARERGEVRDNRGFFAKY 204
            :     |||:.|.. .:.|...||.|....|:
Mouse   793 E-----QKVQHEEAVVKLRHSERDMRNTLEKF 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC10	NP_730662.2	None
Smc4	NP_598547.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
Smc4	NP_598547.1	SMC_N	81..1272	CDD:308206	40/162 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900