DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EMC10 and Smc6

DIOPT Version :9

Sequence 1:	NP_730662.2	Gene:	EMC10 / 40396	FlyBaseID:	FBgn0052441	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_079971.2	Gene:	Smc6 / 67241	MGIID:	1914491	Length:	1097	Species:	Mus musculus

Alignment Length:	225	Identity:	44/225 - (19%)
Similarity:	77/225 - (34%)	Gaps:	81/225 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LGLVSSSWGFLEHD-SWITV-ELQHSLAANSESFSFRGNVTIPS----------------LN--- 56
            |..:.::..:|:|: :|..| |::..|.|      .|.|:.|..                ||
Mouse   270 LSTMKTNLEYLKHEMAWAVVNEIEKQLNA------IRDNIKIGEERAAKLDRKMEEQQVRLNDAE 328

  Fly    57 -------------SGLANVEQPDLSTADLDLLKKLALGNEFYRLKATVVYS---NGAKAQFITSN 105
                         |...|...|:......|::.:....|:     |.|:|:   |..||......
Mouse   329 KKYKDIQDKLEKISEETNARAPECMALKTDVIARTRAFND-----AEVLYNRSLNEYKALKKDGE 388

  Fly   106 KACRLLQAQLNDVLWVSLEPSGYVTGITVSQDTAPATIE-----CTQEDVNKLLETQFSTDVLIR 165
            :.|:.::         .|:.|       ..|...|..:|     |..::..|.|:.|..|  :.:
Mouse   389 QLCKRIE---------ELKKS-------TDQSLEPERLERQKRICWLKEKVKALQDQEHT--VNQ 435

  Fly   166 HAELAPVPDTAGFIQKVEREREARERGEVR 195
            .||        .|.|.:|::::  |.|.||
Mouse   436 EAE--------QFEQAIEKDKQ--EHGRVR 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC10	NP_730662.2	None
Smc6	NP_079971.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		Smc	54..1075	CDD:224117	44/225 (20%)
		ABC_SMC6_euk	54..>210	CDD:213243
		Flexible hinge	458..667
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	813..839
		ABC_SMC6_euk	<983..1081	CDD:213243
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1078..1097
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900