DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EMC10 and smc3

DIOPT Version :9

Sequence 1:	NP_730662.2	Gene:	EMC10 / 40396	FlyBaseID:	FBgn0052441	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_999854.1	Gene:	smc3 / 324475	ZFINID:	ZDB-GENE-030131-3196	Length:	1216	Species:	Danio rerio

Alignment Length:	160	Identity:	34/160 - (21%)
Similarity:	63/160 - (39%)	Gaps:	30/160 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 TIPSLNSGLANVEQPDLS-TADL--DLLKKLALGNEFYRLKATVVYSNGAKAQFITSNKACRLLQ 112
            ::.||.:.|..:|....| .|:|  |||.:|:|.::               .:....|...|.||
Zfish   759 SLQSLEASLHAMESTRESLKAELGADLLSQLSLEDQ---------------RRVDDLNDEIRQLQ 808

  Fly   113 AQLNDVLWVSLEPSGYVTGI-TVSQDTAPATIECTQEDVNKLLETQFSTDVLIRHAEL------- 169
            .....:|...::..|.:|.: |...:.....::..::::|:|.||:..|.:....:||
Zfish   809 QDNRQLLNERIKLEGIMTRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELDGINKRI 873

  Fly   170 ----APVPDTAGFIQKVEREREARERGEVR 195
                |...|....|.|.|.|.:..::...|
Zfish   874 KDTMARSEDLDTLIDKTEVEIKEHQKSMER 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC10	NP_730662.2	None
smc3	NP_999854.1	Smc	1..1193	CDD:224117	34/160 (21%)
		ABC_SMC3_euk	3..>158	CDD:213239
		RILP-like	<222..337	CDD:304877
		BAR	<388..>482	CDD:299863
		SMC_hinge	530..642	CDD:214944
		MIT_CorA-like	<700..>836	CDD:294313	20/91 (22%)
		P-loop_NTPase	<1104..1198	CDD:304359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900