DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EMC10 and smc-4

DIOPT Version :9

Sequence 1:	NP_730662.2	Gene:	EMC10 / 40396	FlyBaseID:	FBgn0052441	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_497935.1	Gene:	smc-4 / 175603	WormBaseID:	WBGene00004874	Length:	1549	Species:	Caenorhabditis elegans

Alignment Length:	172	Identity:	41/172 - (23%)
Similarity:	73/172 - (42%)	Gaps:	33/172 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ITV-ELQHSLAANSESFSFRGNVTIPSL----NSGLANVEQPDLSTADLDLLKKLA-LGNEFYRL 87
            :|| .|:.|:...|.||: .|..|:..|    .:.:|....|:...|:.||.:||. |.:|...|
Worm   743 VTVCTLEGSMIHPSGSFT-GGGKTVKGLILTDKNKMAKQVTPEDKAAERDLAEKLGKLRDEADEL 806

  Fly    88 KATVVYSNGAKAQFITSNKACRLLQAQLNDVLWVSLEPSGYVTGITVS-QDTAPATIECTQEDVN 151
            |......:|            :|::|:..     ..|.|..::.:|.| |..|||.     |.:.
Worm   807 KGQEHEMDG------------QLIEARRK-----VAEMSNRLSIVTSSVQSAAPAI-----ETLK 849

  Fly   152 KLLETQFSTDVLIRHAELAPVPDTAGFIQKVEREREARERGE 193
            |.:..|......:: .:...:.|....::::|::|:  |.||
Worm   850 KTIANQEKEAAKVK-VDAKTLEDKQKIVEELEKKRD--ELGE 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC10	NP_730662.2	None
smc-4	NP_497935.1	ABC_SMC4_euk	90..>252	CDD:213241
		SMC_N	91..1361	CDD:280601	41/172 (24%)
		SMC_hinge	618..734	CDD:284001
		MCP_signal	865..1037	CDD:304920	6/26 (23%)
		ABC_SMC4_euk	<1261..1362	CDD:213241
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900