DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EMC10 and SMC2

DIOPT Version :9

Sequence 1:	NP_730662.2	Gene:	EMC10 / 40396	FlyBaseID:	FBgn0052441	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_001036015.1	Gene:	SMC2 / 10592	HGNCID:	14011	Length:	1197	Species:	Homo sapiens

Alignment Length:	201	Identity:	40/201 - (19%)
Similarity:	75/201 - (37%)	Gaps:	50/201 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VELQHSLAANSESFSF---------------RGNVTIPSLNSGLANVEQPDL-STADLDLLKKLA 79
            ::||..|:.|.:....               .|.: :.||...||..::.:. |.:..||.||..
Human   261 IKLQEELSENDKKIKALNHEIEELEKRKDKETGGI-LRSLEDALAEAQRVNTKSQSAFDLKKKNL 324

  Fly    80 LGNEFYR--LKATVV---------------YSNGAKAQFITSNKACRLLQAQLNDVLWVSLEPSG 127
            ...|..|  |:..:|               .::|..|....|||....|.|.......||
Human   325 ACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVS----- 384

  Fly   128 YVTGITVSQDTAPATIE----CTQEDVNKLLETQFSTDVLIRHAELAPVPDTAGFIQKVE----R 184
              .|::.::|.|.||:.    ..:.|::|.........:.::||: ..:.:....::|::    :
Human   385 --AGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQ-QELKNKQAEVKKMDSGYRK 446

  Fly   185 EREARE 190
            ::||.|
Human   447 DQEALE 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC10	NP_730662.2	None
SMC2	NP_001036015.1	Smc	1..1168	CDD:224117	40/201 (20%)
		ABC_SMC2_euk	1..>172	CDD:213240
		Uds1	<193..287	CDD:292096	4/25 (16%)
		L_lactis_ph-MCP	252..>465	CDD:115336	40/201 (20%)
		SMC_hinge	522..639	CDD:214944
		DUF342	<636..777	CDD:302792
		DUF4200	740..841	CDD:290574
		P-loop_NTPase	<1074..1168	CDD:304359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900