DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EMC10 and SMC4

DIOPT Version :9

Sequence 1:	NP_730662.2	Gene:	EMC10 / 40396	FlyBaseID:	FBgn0052441	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_001002800.1	Gene:	SMC4 / 10051	HGNCID:	14013	Length:	1288	Species:	Homo sapiens

Alignment Length:	164	Identity:	37/164 - (22%)
Similarity:	66/164 - (40%)	Gaps:	43/164 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LANVEQPDLSTADLDLLKKLALGNE------FYRLKATVVYSNGAKAQFITSNKACR----LLQA 113
            :..::.|:.:....||:|   :.:|      ::.|:.|:|..|..:|..:...|..|    .||.
Human   681 MTEIQTPENTPRLFDLVK---VKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQG 742

  Fly   114 QLNDVLWVSLEPSGYVTG----ITVSQDTAPATIECTQEDVNKLLETQFSTD------------- 161
            |:       :|.||.:||    :...:..:...||.::|:||| :|:|...|
Human   743 QI-------IEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNK-MESQLQNDSKKAMQIQEQKVQ 799

  Fly   162 -----VLIRHAELAPVPDTAGFIQKVEREREARE 190
                 |.:||:|.........|...::|..|..|
Human   800 LEERVVKLRHSEREMRNTLEKFTASIQRLIEQEE 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC10	NP_730662.2	None
SMC4	NP_001002800.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		ABC_SMC4_euk	82..>241	CDD:213241
		SMC_N	83..1274	CDD:280601	37/164 (23%)
		DUF4349	<327..427	CDD:305044
		SMC_hinge	613..727	CDD:214944	10/48 (21%)
		ABC_SMC4_euk	<1181..1275	CDD:213241
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900