DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7634 and wa-cup

DIOPT Version :9

Sequence 1:	NP_649332.1	Gene:	CG7634 / 40394	FlyBaseID:	FBgn0037101	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_649721.2	Gene:	wa-cup / 40892	FlyBaseID:	FBgn0037502	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	227/552 - (41%)
Similarity:	318/552 - (57%)	Gaps:	33/552 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GVEAAVPVWFKMDWSPEIEQGIYKDWGTYYSRRRRENLGMYYFDKALKLGPADFTTLYRRSQSKR 80
            ||:..:..|....|||:....:|.||..::..::|...|:.||:.||.|.|.:...|.||||.||
  Fly    17 GVQPHLQPWEAHAWSPDRLGSMYSDWAMFFFTQQRYANGLRYFNSALDLNPFNERALMRRSQLKR 81

  Fly    81 KNAQADGALKDSLEAKRLLKNLQR--YDAPINLEVCDALYELNQLENAKAELHDNTRLFTGNKTK 143
            ....|..||||...|:.||.:.:.  .:..::|||||||||.|:||::|..||.:.:.|:..:..
  Fly    82 SMGLASEALKDCSRAEDLLMSRKPPVTNPNVSLEVCDALYESNRLEDSKINLHCHLKRFSSGQRG 146

  Fly   144 MFEQRLVVVDENIEDACGPSMTQYISDKEKLIVHLKEVQNKYKPDTRPLWKILKE----QEKCDV 204
            ....||.|::||..|......|..:   ::||             .|.:..:.||    ::.|||
  Fly   147 PVLDRLNVLNENFHDTLSDDTTMSV---QRLI-------------NRMMASLAKEPKDIKDTCDV 195

  Fly   205 LSIPEIEEEMLSPLEIARRSRAFDVFNQMFIDRSWHDVIFLKHVRKNPNLLLNQCKNSTEYLQTL 269
            :||.|.||..|||||:|||.|.|.::||.::::.|.||.|||.:|.:||:|...||.|:|||..|
  Fly   196 VSIMENEETHLSPLEMARRKRHFKIYNQTYLNKCWVDVAFLKTLRDDPNVLPKHCKKSSEYLGKL 260

  Fly   270 STKKYDEIKSFLKILEARSPMYNIRYQKFTNKKLMDKFRQEYLFRVQYQTRRNMISALRSIRYLR 334
            ....|...::..|.|..|||||.:..||:.|:...:|.|:|.|:|:||||||||...|||||.|.
  Fly   261 MASNYKAERTLTKTLHTRSPMYALHQQKYPNEAFYNKHREENLYRIQYQTRRNMFKILRSIRLLI 325

  Fly   335 KTKSLTKLTSYVEEVMGDYVVKKTNRIMPWKFEFINEVYNILALAYVDQYTLPKNFRFSE-KNAL 398
            :...|.|||:::||||||||..||||:|||||||.|||||.|.||.:::|.:|.|....: |..|
  Fly   326 RVGELNKLTTFIEEVMGDYVTIKTNRVMPWKFEFTNEVYNYLGLARINEYKIPSNMTVLQGKQRL 390

  Fly   399 LRLLRFPMDKSKEVKHFVFGDRTTHQG------SETVDPALTKSRLMGNRLENRMNFAKYPIEKS 457
            |.|.|.|:..|.::|.    .:|....      |.|.||.....:....||||||.||:|.||::
  Fly   391 LTLFRLPLSNSLDMKK----SKTKRTSALNITRSATTDPKAEHFKKQVVRLENRMRFAEYHIERA 451

  Fly   458 YLLHQMAEIHLKSHRFDECCFSARKSIEEAKKCNSYIWQFLCYLLIIKANAALHKVERTSEALDL 522
            ||||::|:.||..:.||..|..||.::|||.||.|.||.||..::|.||:|.|.|:||..|.|..
  Fly   452 YLLHELAQEHLNCNSFDGACSMARMALEEAIKCKSVIWSFLSLMVICKAHAILGKIEREKEILAE 516

  Fly   523 ALKISKELKEKHIHNFLTACIHCNEEEFIVKK 554
            |.:::|::|...:..|:..||..|.||..:|:
  Fly   517 AFELAKKMKNLDLCLFIDICIKVNAEEMEMKR 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7634	NP_649332.1	None
wa-cup	NP_649721.2	TPR_11	39..99	CDD:290150	24/59 (41%)
		TPR repeat	39..64	CDD:276809	8/24 (33%)
		TPR repeat	69..99	CDD:276809	13/29 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450492
Domainoid	1	1.000	152	1.000	Domainoid score	I8865
eggNOG	1	0.900	-	-		E1_2BEUU
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	152	1.000	Inparanoid score	I6773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009964
OrthoInspector	1	1.000	-	-		otm50006
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR21391
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7635
	9	8.890