Protein Alignment CapaR and CCKBR

DIOPT Version :10

• Sequence 1: NP_996140.1
• Gene: CapaR / 40393
• FlyBaseID: FBgn0037100
• Length: 477
• Species: Drosophila melanogaster
• Sequence 2: NP_001350481.1
• Gene: CCKBR / 887
• HGNCID: 1571
• Length: 516
• Species: Homo sapiens
• Alignment Length: 474
• Identity: 100/474 - (21%)
• Similarity: 163/474 - (34%)
• Gaps: 184/474 - (38%)

  Fly    44 GTFNCSPKEFVAFVLGPQTLPLYKAVLITIIFGGIFITGVVGNLLVCIVIIRHSAMHTATNYYLF 108
            |..:|.|..    :.|..|..|..|:.|| ::..||:..|.||:|:.:|:.....:.|.||.:|.
Human    35 GNLSCEPPR----IRGAGTRELELAIRIT-LYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLL 94

  Fly   109 SLAVSDLLYLLFGLPTEVFLYWHQYPDL-----FGMPFCKIRAFISEACTYVSVFTIVAFSMERF 168
            ||||||||..:..:|..:.      |:|     ||...||..:::......||..::||.::||:
Human    95 SLAVSDLLLAVACMPFTLL------PNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERY 153

  Fly   169 LAICHPLHLYAMVGFKRAIRIITALWIVSFISAIPFGLLSDIQYLNYPLDHSRIEESAFCSMSPK 233
            .|||.||..........|.|:|.|.|::|.:..:|:.:.:.:|                 .:.|:
Human   154 SAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQ-----------------PVGPR 201

  Fly   234 I---VNEIPVFEVS-------FCIFFVIPMILIILLYGRM------------------------- 263
            :   |:..|...|.       ..:.|.||.:::.:.||.:
Human   202 VLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQ 266

  Fly   264 -----------------------------GAKIRSRTNQKLGVQ--------------------- 278
                                         |.:::.|..:||.::
Human   267 GGLPGGAGPREQNLGEAELWRATGPAGVGGTEMKVRVRRKLEMELSWERRSGGDWAGDWGDSPFS 331

  Fly   279 ---------------------------------------------------QGTNNRETRNSQMR 292
                                                               .|:.:|.|:...:.
Human   332 LTAHPLCSGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLA 396

  Fly   293 KKTVIRMLAAVVITFFVCWFPFHLQRLIFLYAKNMDNYLD-------INEALFSIAGFAYYVSCT 350
            ||.|:|||..:|:.||:||.|        :|:.|.....|       ::.|..|......|.|..
Human   397 KKRVVRMLLVIVVLFFLCWLP--------VYSANTWRAFDGPGAHRALSGAPISFIHLLSYASAC 453

  Fly   351 VNPIVYSVMSRRYRVAFRE 369
            |||:||..|.||:|.|..|
Human   454 VNPLVYCFMHRRFRQACLE 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tmA_capaR	83..367	CDD:320262	87/431 (20%)
		TM helix 2	103..129	CDD:320262	12/25 (48%)
		TM helix 3	142..172	CDD:320262	9/29 (31%)
		TM helix 4	184..206	CDD:320262	7/21 (33%)
		TM helix 5	237..266	CDD:320262	8/89 (9%)
		TM helix 6	291..321	CDD:320262	12/29 (41%)
		TM helix 7	335..360	CDD:320262	9/24 (38%)
CCKBR	NP_001350481.1	7tm_GPCRs	55..470	CDD:475119	92/446 (21%)
		TM helix 1	57..81	CDD:320645	9/24 (38%)
		TM helix 2	90..112	CDD:320645	11/21 (52%)
		TM helix 3	128..150	CDD:320645	5/21 (24%)
		TM helix 4	173..189	CDD:320645	5/15 (33%)
		TM helix 5	216..239	CDD:320645	3/22 (14%)
		TM helix 6	401..423	CDD:320645	10/29 (34%)
		TM helix 7	438..463	CDD:320645	9/24 (38%)