DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and nmur1a

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	XP_021325138.1	Gene:	nmur1a / 557276	ZFINID:	ZDB-GENE-081104-220	Length:	428	Species:	Danio rerio

Alignment Length:	458	Identity:	139/458 - (30%)
Similarity:	231/458 - (50%)	Gaps:	72/458 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SSTDPTFSELNASFTNTP----DTLFATSVSSDPSHGFGEEDYACGTFNCSPKEFVAFVLGPQTL 63
            ||||          ::||    |.|..|||:.:.:....|:      |.....|::...|||:..
Zfish     8 SSTD----------SSTPKCIQDLLCNTSVALNLTEMEIED------FCLDQDEYLEKYLGPRRS 56

  Fly    64 PLYKAVLITIIFGGIFITGVVGNLLVCIVIIRHSAMHTATNYYLFSLAVSDLLYLLFGLPTEVFL 128
            |::..|.:|.:.  ||:.|.|||:|.||||.::..|.|.||:||||||:||||.||.|:|.|::.
Zfish    57 PVFLPVCLTYLL--IFLVGAVGNILTCIVIAKNKVMRTPTNFYLFSLAISDLLVLLLGMPLELYE 119

  Fly   129 YWHQYPDLFGMPFCKIRAFISEACTYVSVFTIVAFSMERFLAICHPLHLYAMVGFKRAIRIITAL 193
            .|..||.|.|...|..:..:.|...:.|:..:.|.|:||::|:.|||....:|....|.|:|.::
Zfish   120 MWSNYPFLLGKGGCYFKTLLFETVCFASILNVTALSVERYIAVIHPLRAKYVVTRTHAKRLILSV 184

  Fly   194 WIVSFISAIPFGLLSDIQYLNYPLDHSR--IEESAFCSM-SPKIVNEIPVFEVSFCIFFVIPMIL 255
            |.:|.:.|||..:|..|..|..|...:.  :.:||.|.: .|:.:..: :.:::..:||::||:.
Zfish   185 WSISVLCAIPNTILHGIFTLPPPKGKAAGVMLDSATCMLVKPRWMYNL-IIQITTLLFFLLPMLT 248

  Fly   256 IILLYGRMGAKI-RSRTNQKL------GVQQGTNNRETRNSQMRKKTVIRMLAAVVITFFVCWFP 313
            |.:||..:|.:: |.:..|.|      |:...:|.| ::..:.|::.|.:||..:|:.|.:||.|
Zfish   249 ISVLYLLIGMQLKREKMLQVLEAKASSGLDSSSNVR-SQQQKTRRQQVTKMLFVLVVMFGICWAP 312

  Fly   314 FHLQRLIFLYAKNMDN----YLDINEALFSIAGFAYYVSCTVNPIVYSVMSRRYRVAFRELLCGK 374
            ||..||::.:....|:    ..::.|.:..|:|..:|:|..:||::|::||.|:|..|:|::|
Zfish   313 FHTDRLMWSFMDQKDSEHIEIFEVYEYVHVISGVFFYLSSAINPVLYNLMSTRFREMFKEVMC-- 375

  Fly   375 AVGAYYNSGFARDHSSFRESSAYDRVHSVHVRASQHPNKFETDSSSANRVLIKKTYSLPLPKNAD 439
                         |..:|..                |.|   .|.|..||.::.|.|...|.|..
Zfish   376 -------------HHKWRPV----------------PRK---RSLSMTRVTVRSTVSDVPPCNGT 408

  Fly   440 STV 442
            .|:
Zfish   409 VTI 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	102/302 (34%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	94/284 (33%)
nmur1a	XP_021325138.1	7tmA_NMU-R1	60..370	CDD:320480	105/313 (34%)
		TM helix 1	60..87	CDD:320480	13/28 (46%)
		TM helix 2	94..120	CDD:320480	17/25 (68%)
		TM helix 3	133..163	CDD:320480	8/29 (28%)
		TM helix 4	175..197	CDD:320480	8/21 (38%)
		TM helix 5	230..259	CDD:320480	8/29 (28%)
		TM helix 6	290..320	CDD:320480	13/29 (45%)
		TM helix 7	338..363	CDD:320480	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578484
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BGH7
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	1	1.000	-	-		FOG0001494
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	1	1.000	-	-		X673
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.880