DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CapaR and GPR39

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001499.1	Gene:	GPR39 / 2863	HGNCID:	4496	Length:	453	Species:	Homo sapiens

Alignment Length:	414	Identity:	101/414 - (24%)
Similarity:	190/414 - (45%)	Gaps:	55/414 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 VLITIIFGGIFITGVVGN---LLVCIVIIRHSAMHTATNYYLFSLAVSDLLYLLFGLPTEVF-LY 129
            :.:.:::..||:.|::||   :.|..|:.:...:......::.|||.||:|..|.|:|.|.: :.
Human    31 ITLILVYLIIFVMGLLGNSATIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSII 95

  Fly   130 WHQYPDLFGMPFCKIRAFISEACTYVSVFTIVAFSMERFLAICHPLHLYAMVGFKRAIRIITALW 194
            |:..........||:..|:.|||:|.::..::..|.||::|||||....|:.|..:...:|..:|
Human    96 WNPLTTSSYTLSCKLHTFLFEACSYATLLHVLTLSFERYIAICHPFRYKAVSGPCQVKLLIGFVW 160

  Fly   195 IVSFISAIP--FGLLSDIQYLNYP-----------LDHSRIEESAFCSMSPKIVNEIPVFEVS-- 244
            :.|.:.|:|  |.:.::...:|.|           ..|....|::..|:...:.:...||:.|
Human   161 VTSALVALPLLFAMGTEYPLVNVPSHRGLTCNRSSTRHHEQPETSNMSICTNLSSRWTVFQSSIF 225

  Fly   245 --FCIFFVIPMILIILLYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQ------MRKKTVIRMLA 301
              |.::.|:.:.:..:.:..|...::|   ||..:..||...:.|.|:      .|::|:| .|.
Human   226 GAFVVYLVVLLSVAFMCWNMMQVLMKS---QKGSLAGGTRPPQLRKSESEESRTARRQTII-FLR 286

  Fly   302 AVVITFFVCWFPFHLQRLIFLYAKNMD---NYLDINEALFSIAGFAYYVSCTVNPIVYSVMSRRY 363
            .:|:|..|||.|..::|::.......|   :|......|...:...:|:|..:||::|:|.|:::
Human   287 LIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQF 351

  Fly   364 RVAFRELLCGKAVGAYYNSGFARDHSSFRESSAYDRVHSVH-----VRASQHPNKFET-DSSSAN 422
            |..|.::||.:         .:..|::..:..   |||: |     .|..|.|..|.: ..|||.
Human   352 RRVFVQVLCCR---------LSLQHANHEKRL---RVHA-HSTTDSARFVQRPLLFASRRQSSAR 403

  Fly   423 RV--LIKKTYSLPLPKNADSTVLS 444
            |.  :...|:.......:.|..||
Human   404 RTEKIFLSTFQSEAEPQSKSQSLS 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	81/318 (25%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	74/300 (25%)
GPR39	NP_001499.1	7tmA_GPR39	31..355	CDD:320263	81/327 (25%)
		TM helix 1	31..58	CDD:320263	6/26 (23%)
		TM helix 2	68..94	CDD:320263	10/25 (40%)
		TM helix 3	108..138	CDD:320263	11/29 (38%)
		TM helix 4	150..172	CDD:320263	5/21 (24%)
		TM helix 5	217..246	CDD:320263	5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..274		4/18 (22%)
		TM helix 6	276..306	CDD:320263	11/30 (37%)
		TM helix 7	323..348	CDD:320263	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..453		3/13 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380940at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920