DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and srw-113

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_506802.1	Gene:	srw-113 / 191503	WormBaseID:	WBGene00005860	Length:	344	Species:	Caenorhabditis elegans

Alignment Length:	337	Identity:	74/337 - (21%)
Similarity:	144/337 - (42%)	Gaps:	52/337 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 ITIIFGGIFITGVVGNLLVCIVIIRHSAMHTATNYYLFSLAVSDL-----LYLLFGLPTEVFLYW 130
            :|.|...|....|:.||....::.|.|..:|:.|..:.:.|..|:     :.:...:..::.:|.
Worm    35 LTYITPHISFLCVLINLFHFTILTRKSMRNTSINIIMAAAAFCDIFSFIEMLMRIYVNVQMLIYA 99

  Fly   131 HQYPDLFGMPFCKIRAF--ISEACTYVSVFTIVAFSMERFLAICHPL--HLYAMVGFKRAIRIIT 191
            ....|.:......| ||  :.:.....|.:.|:..:..|.|.|.:|:  .:..:...|.|..||:
Worm   100 CYGEDSYSRLAVDI-AFEIVKKTAQRASTWLILMIAFIRALVIRYPMSSRIEKLTTPKVAFIIIS 163

  Fly   192 ALWIVSFISAIPFGLL--SDIQYLNY-------PLDHSRI------EESAFCSMSPKIVNEIPVF 241
            |:.|:|    |||.||  :|||::.|       |....:|      :.:.:.:::..:.|:||
Worm   164 AVVIIS----IPFSLLNYNDIQFMEYIATTKCFPNGTMKILMVFGRKVATYNAITAIVTNDIP-- 222

  Fly   242 EVSFCIFFVIPMILIILLYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQMRKKTVIRMLAAVVIT 306
                |:.|.|..:|:::       :||.....:..:...||.::.:.       :.|::....:.
Worm   223 ----CVLFPILSLLLVI-------EIRKADKNQKRLTAPTNAQDFQR-------ITRLVLYNTLI 269

  Fly   307 FFVCWFPFHLQRLIFLYAKNMDNYLDINEALFSIAGFAYYVSCTVNPIVYSVMSRRYR-VAFREL 370
            ||....|..:.|.:..:.:.:  ...:...:.|||.....|:.|.:.|:|.:||.:|| .|.:..
Worm   270 FFATLLPLGITRGLLYFPRGL--VWSVAREIESIAATILTVNTTTHCIIYLLMSSQYRGTAKQTF 332

  Fly   371 LCGKAVGAYYNS 382
            |||..:.|..|:
Worm   333 LCGFDIQAIENT 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	67/313 (21%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	59/294 (20%)
srw-113	NP_506802.1	TM helix 1	36..59	CDD:320109	6/22 (27%)
		7TM_GPCR_Srw	37..335	CDD:370978	69/324 (21%)
		TM helix 2	68..90	CDD:320109	3/21 (14%)
		TM helix 3	111..135	CDD:320109	5/24 (21%)
		TM helix 4	160..181	CDD:320109	11/24 (46%)
		TM helix 5	208..231	CDD:320109	6/28 (21%)
		TM helix 6	257..282	CDD:320109	4/31 (13%)
		TM helix 7	296..321	CDD:320109	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910