DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CapaR and srw-38

DIOPT Version :9

Sequence 1:	NP_996140.1	Gene:	CapaR / 40393	FlyBaseID:	FBgn0037100	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_507842.1	Gene:	srw-38 / 191017	WormBaseID:	WBGene00005785	Length:	367	Species:	Caenorhabditis elegans

Alignment Length:	344	Identity:	81/344 - (23%)
Similarity:	132/344 - (38%)	Gaps:	84/344 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 IFITGVVGNLLVCIVIIRHSAMHTATNYYLFSLAVSDLLYLLFGL----PTEVFLYWHQYPDLFG 138
            |...|:..:|....|:.|.|..|..||.:|..:.:..:::::..:    |. ::.|:..:...|.
Worm    41 ISFIGIFPSLFHFWVLTRESMRHLTTNLFLIGMTLCGIIHMICNIIEFCPL-LYNYYFSFEISFE 104

  Fly   139 -MPFCKIRAFISE--------ACTYVSVFTIVAFSMERFLAICHPLH------LYAMVGFK---R 185
             .||......:|.        ..|.:..:..||.::.|||.:..|..      :|:..|.|   .
Worm   105 CFPFASYSKIVSNYYSSMTNAVVTGMLTYFTVAMAIIRFLVVKFPFARSMQRLIYSKSGLKILLP 169

  Fly   186 AIRIITALWIVSFISA--------IPFGLLSDIQYLNYPLDHSRIEESAFCSMSPKIVNEIP--- 239
            .|.:|..|||....|.        :| |...||...||......:|.|        |...|.
Worm   170 IIILILPLWIAEISSTNIVETGIWVP-GPNCDIFAENYTEKMYTVETS--------ITFGIDDFY 225

  Fly   240 --VFEVSFCIFFVIPMILI----ILLYGRMGAKIRSRTNQKLGVQQGTNNRETRNSQMRKKTVIR 298
              |:.:...||..||.||:    :||.      |..:.|:|      |....:::.....|.|:.
Worm   226 WIVYYIYAVIFQFIPSILLPISTVLLI------IELKKNKK------TKTWTSKSQDRSTKLVVY 278

  Fly   299 MLAAVVITFFVCWFPFHL-QRLIFL---YAKNMDNYLDINEALFSIAGFAYYVSCTVNPIVYSV- 358
            |    .|:|.:...|:.| ..|.|:   ||:.:.:.|.:      ||    |:..|:|...:.:
Worm   279 M----TISFIMANAPYSLIYSLSFMLSAYARMIISQLSV------IA----YLLTTLNVATHWLL 329

  Fly   359 ---MSRRYRVAFRELLCGK 374
               ||.:||...||:| ||
Worm   330 CYFMSTQYRNTAREIL-GK 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CapaR	NP_996140.1	7tm_4	85..374	CDD:304433	77/335 (23%)
CapaR	NP_996140.1	7tm_1	85..356	CDD:278431	70/313 (22%)
srw-38	NP_507842.1	7TM_GPCR_Srw	39..348	CDD:370978	81/344 (24%)
		TM helix 2	66..91	CDD:341315	3/24 (13%)
		TM helix 3	109..147	CDD:341315	7/37 (19%)
		TM helix 4	162..186	CDD:341315	8/23 (35%)
		TM helix 5	225..250	CDD:341315	7/24 (29%)
		TM helix 6	270..297	CDD:341315	7/30 (23%)
		TM helix 7	309..334	CDD:341315	6/34 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910